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Self- and informant reports of executive function on the BRIEF-A in MCI and older adults with cognitive complaints.
Arch Clin Neuropsychol 2006; 21(7):721-32AC

Abstract

Amnestic mild cognitive impairment (MCI) is characterized by impaired episodic memory, although subtle executive problems have been noted on neuropsychological tests. Recent research also has described a group of healthy, non-depressed older adults with significant cognitive complaints (CC) but normal performance on neuropsychological testing. These individuals show structural and functional brain changes intermediate between those seen in MCI and healthy older adults without such complaints (HC). We evaluated executive functions in MCI and CC using the Behavior Rating Inventory of Executive Function-Adult version (BRIEF-A), a newly developed self- and informant report questionnaire in 29 patients with amnestic MCI, 28 CCs, and 30 demographically matched HCs. MCI and CC participants reported significant difficulties with selective aspects of executive functioning relative to HCs despite clinically normal performance on neuropsychological tests of this cognitive domain. Scores were generally in the pattern of MCI>CC>HC, and findings were most pronounced for working memory. Additionally, MCI and CC participants were more likely than their informants to report clinically meaningful executive problems, though informants identified a similar pattern of difficulty overall. Results failed to reveal strong relations between the BRIEF-A and standardized neuropsychological tests of executive function. Overall findings indicate that the BRIEF-A is sensitive to subtle executive changes in MCI and CC and suggest the need for research to determine if executive complaints are predictive of clinical course.

Authors+Show Affiliations

Neuropsychology Program, Department of Psychiatry, Dartmouth Medical School/DHMC, Lebanon, NH, USA. lrabin@brooklyn.cuny.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16979868

Citation

Rabin, Laura A., et al. "Self- and Informant Reports of Executive Function On the BRIEF-A in MCI and Older Adults With Cognitive Complaints." Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists, vol. 21, no. 7, 2006, pp. 721-32.
Rabin LA, Roth RM, Isquith PK, et al. Self- and informant reports of executive function on the BRIEF-A in MCI and older adults with cognitive complaints. Arch Clin Neuropsychol. 2006;21(7):721-32.
Rabin, L. A., Roth, R. M., Isquith, P. K., Wishart, H. A., Nutter-Upham, K. E., Pare, N., ... Saykin, A. J. (2006). Self- and informant reports of executive function on the BRIEF-A in MCI and older adults with cognitive complaints. Archives of Clinical Neuropsychology : the Official Journal of the National Academy of Neuropsychologists, 21(7), pp. 721-32.
Rabin LA, et al. Self- and Informant Reports of Executive Function On the BRIEF-A in MCI and Older Adults With Cognitive Complaints. Arch Clin Neuropsychol. 2006;21(7):721-32. PubMed PMID: 16979868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Self- and informant reports of executive function on the BRIEF-A in MCI and older adults with cognitive complaints. AU - Rabin,Laura A, AU - Roth,Robert M, AU - Isquith,Peter K, AU - Wishart,Heather A, AU - Nutter-Upham,Katherine E, AU - Pare,Nadia, AU - Flashman,Laura A, AU - Saykin,Andrew J, Y1 - 2006/09/18/ PY - 2006/04/20/received PY - 2006/07/03/revised PY - 2006/08/16/accepted PY - 2006/9/19/pubmed PY - 2007/1/4/medline PY - 2006/9/19/entrez SP - 721 EP - 32 JF - Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists JO - Arch Clin Neuropsychol VL - 21 IS - 7 N2 - Amnestic mild cognitive impairment (MCI) is characterized by impaired episodic memory, although subtle executive problems have been noted on neuropsychological tests. Recent research also has described a group of healthy, non-depressed older adults with significant cognitive complaints (CC) but normal performance on neuropsychological testing. These individuals show structural and functional brain changes intermediate between those seen in MCI and healthy older adults without such complaints (HC). We evaluated executive functions in MCI and CC using the Behavior Rating Inventory of Executive Function-Adult version (BRIEF-A), a newly developed self- and informant report questionnaire in 29 patients with amnestic MCI, 28 CCs, and 30 demographically matched HCs. MCI and CC participants reported significant difficulties with selective aspects of executive functioning relative to HCs despite clinically normal performance on neuropsychological tests of this cognitive domain. Scores were generally in the pattern of MCI>CC>HC, and findings were most pronounced for working memory. Additionally, MCI and CC participants were more likely than their informants to report clinically meaningful executive problems, though informants identified a similar pattern of difficulty overall. Results failed to reveal strong relations between the BRIEF-A and standardized neuropsychological tests of executive function. Overall findings indicate that the BRIEF-A is sensitive to subtle executive changes in MCI and CC and suggest the need for research to determine if executive complaints are predictive of clinical course. SN - 0887-6177 UR - https://www.unboundmedicine.com/medline/citation/16979868/Self__and_informant_reports_of_executive_function_on_the_BRIEF_A_in_MCI_and_older_adults_with_cognitive_complaints_ L2 - http://linkinghub.elsevier.com/retrieve/pii/S0887-6177(06)00107-7 DB - PRIME DP - Unbound Medicine ER -