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Serum insulin levels and the prevalence of adenomatous and hyperplastic polyps in the proximal colon.
Clin Gastroenterol Hepatol 2006; 4(10):1225-31CG

Abstract

BACKGROUND & AIMS

Obesity and diabetes mellitus are associated with an increased incidence of proximal colon cancer. Colonic adenoma that has been reported to be associated with elevated serum insulin levels and subsets of hyperplastic polyps might serve as a precursor of colon cancer. In this study, we sought to determine segment-specific associations between serum insulin levels and the prevalence of adenoma and hyperplastic polyps in the proximal and distal colon.

METHODS

We studied 343 consecutive patients who underwent colonoscopy in our hospital. All medical information, including fasting serum insulin, was obtained at colonoscopy. We performed multinomial logistic regression models by using the outcome categories of none (reference), proximal-only, distal-only, and both-segment lesions for the presence of adenoma/hyperplastic polyp with serum insulin, age, gender, lifestyle characteristics, and the presence of other types of lesions as predictors. Odds ratios (ORs) and 95% confidence intervals (CIs) are provided for a 5-muU/mL increase in serum insulin.

RESULTS

Overall, serum insulin levels were significantly associated with adenoma (OR, 1.5; 95% CI, 1.1-2.0; P = .005) and borderline associated with hyperplastic polyps (OR, 1.3; 95% CI, 1.0-1.7; P = .075). In multinomial logistic regression models, elevated serum insulin levels were significantly associated with proximal-only adenoma (OR, 1.8; 95% CI, 1.2-2.5; P = .002), both-side hyperplastic polyp (OR, 1.7; 95% CI, 1.1-2.5; P = .015), and proximal-only hyperplastic polyp (OR, 1.5; 95% CI, 1.0-2.1; P = .048) and borderline associated with distal-only adenoma (OR, 1.5; 95% CI, 1.0-2.1; P =.059) but not with distal-only hyperplastic polyp.

CONCLUSIONS

Serum insulin levels directly correlate with the presence of adenoma and hyperplastic polyps in the proximal colon and might also less strongly correlate with the presence of distal adenoma.

Authors+Show Affiliations

Second Department of Internal Medicine, Kanazawa University [corrected] and Hokuriku Hospital, Kanazawa, Ishikawa, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16979948

Citation

Yoshida, Isao, et al. "Serum Insulin Levels and the Prevalence of Adenomatous and Hyperplastic Polyps in the Proximal Colon." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 4, no. 10, 2006, pp. 1225-31.
Yoshida I, Suzuki A, Vallée M, et al. Serum insulin levels and the prevalence of adenomatous and hyperplastic polyps in the proximal colon. Clin Gastroenterol Hepatol. 2006;4(10):1225-31.
Yoshida, I., Suzuki, A., Vallée, M., Matano, Y., Masunaga, T., Zenda, T., ... Okada, T. (2006). Serum insulin levels and the prevalence of adenomatous and hyperplastic polyps in the proximal colon. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 4(10), pp. 1225-31.
Yoshida I, et al. Serum Insulin Levels and the Prevalence of Adenomatous and Hyperplastic Polyps in the Proximal Colon. Clin Gastroenterol Hepatol. 2006;4(10):1225-31. PubMed PMID: 16979948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum insulin levels and the prevalence of adenomatous and hyperplastic polyps in the proximal colon. AU - Yoshida,Isao, AU - Suzuki,Ayako, AU - Vallée,Marc, AU - Matano,Yutaka, AU - Masunaga,Takaharu, AU - Zenda,Takahiro, AU - Shinozaki,Kimihide, AU - Okada,Toshihide, Y1 - 2006/09/18/ PY - 2006/9/19/pubmed PY - 2007/1/11/medline PY - 2006/9/19/entrez SP - 1225 EP - 31 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 4 IS - 10 N2 - BACKGROUND & AIMS: Obesity and diabetes mellitus are associated with an increased incidence of proximal colon cancer. Colonic adenoma that has been reported to be associated with elevated serum insulin levels and subsets of hyperplastic polyps might serve as a precursor of colon cancer. In this study, we sought to determine segment-specific associations between serum insulin levels and the prevalence of adenoma and hyperplastic polyps in the proximal and distal colon. METHODS: We studied 343 consecutive patients who underwent colonoscopy in our hospital. All medical information, including fasting serum insulin, was obtained at colonoscopy. We performed multinomial logistic regression models by using the outcome categories of none (reference), proximal-only, distal-only, and both-segment lesions for the presence of adenoma/hyperplastic polyp with serum insulin, age, gender, lifestyle characteristics, and the presence of other types of lesions as predictors. Odds ratios (ORs) and 95% confidence intervals (CIs) are provided for a 5-muU/mL increase in serum insulin. RESULTS: Overall, serum insulin levels were significantly associated with adenoma (OR, 1.5; 95% CI, 1.1-2.0; P = .005) and borderline associated with hyperplastic polyps (OR, 1.3; 95% CI, 1.0-1.7; P = .075). In multinomial logistic regression models, elevated serum insulin levels were significantly associated with proximal-only adenoma (OR, 1.8; 95% CI, 1.2-2.5; P = .002), both-side hyperplastic polyp (OR, 1.7; 95% CI, 1.1-2.5; P = .015), and proximal-only hyperplastic polyp (OR, 1.5; 95% CI, 1.0-2.1; P = .048) and borderline associated with distal-only adenoma (OR, 1.5; 95% CI, 1.0-2.1; P =.059) but not with distal-only hyperplastic polyp. CONCLUSIONS: Serum insulin levels directly correlate with the presence of adenoma and hyperplastic polyps in the proximal colon and might also less strongly correlate with the presence of distal adenoma. SN - 1542-3565 UR - https://www.unboundmedicine.com/medline/citation/16979948/Serum_insulin_levels_and_the_prevalence_of_adenomatous_and_hyperplastic_polyps_in_the_proximal_colon_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(06)00713-0 DB - PRIME DP - Unbound Medicine ER -