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Total antioxidant status and oxygen free radicals during hepatic regeneration.
Transplant Proc 2006; 38(7):2214-5TP

Abstract

OBJECTIVES

The damage induced by oxygen free radicals (OFRs) is caused by an imbalance of the production of versus the antioxidant defenses against OFRs.

METHODS

To understand hepatic damage induced by oxygen free radicals after hepatectomy in rats, total antioxidant status and total production of oxygen free radicals were serially measured in regeneration liver. At 1, 2, 3, 7, and 10 days after hepatectomy of Sprague-Dawley rats, blood was obtained into a capillary tube from a tail vein. Total antioxidant status and total production of oxygen free radicals were measured using the Randox kit, a colorimetric method, and the Free Radical Analytical System. We also measured the amount of malonyldialdehyde, which provides an indirect index of oxidative injury.

RESULTS

The level of malonyldialdehyde after hepatectomy was higher compared with that before hepatectomy. The level of total oxygen free radicals after hepatectomy was higher compared with that before hepatectomy. Total antioxidant status after hepatectomy was lower compared with that before hepatectomy.

CONCLUSIONS

The results suggested that the damage by OFRs to the regenerating liver was caused by increased production of OFRs and decreased antioxidant defense against OFRs.

Authors+Show Affiliations

Dongsan Kidney Institute and Chronic Disease Research Center, Keimyung University School of Medicine, 194 Dong San Dong, Daegu 700-712, Korea.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16980046

Citation

Han, S Y., et al. "Total Antioxidant Status and Oxygen Free Radicals During Hepatic Regeneration." Transplantation Proceedings, vol. 38, no. 7, 2006, pp. 2214-5.
Han SY, Chang EJ, Choi HJ, et al. Total antioxidant status and oxygen free radicals during hepatic regeneration. Transplant Proc. 2006;38(7):2214-5.
Han, S. Y., Chang, E. J., Choi, H. J., Nam, S. I., Lee, N. H., Kwak, C. S., ... Mun, K. C. (2006). Total antioxidant status and oxygen free radicals during hepatic regeneration. Transplantation Proceedings, 38(7), pp. 2214-5.
Han SY, et al. Total Antioxidant Status and Oxygen Free Radicals During Hepatic Regeneration. Transplant Proc. 2006;38(7):2214-5. PubMed PMID: 16980046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Total antioxidant status and oxygen free radicals during hepatic regeneration. AU - Han,S Y, AU - Chang,E J, AU - Choi,H J, AU - Nam,S I, AU - Lee,N H, AU - Kwak,C S, AU - Park,S B, AU - Kim,H C, AU - Mun,K C, PY - 2006/9/19/pubmed PY - 2006/12/12/medline PY - 2006/9/19/entrez SP - 2214 EP - 5 JF - Transplantation proceedings JO - Transplant. Proc. VL - 38 IS - 7 N2 - OBJECTIVES: The damage induced by oxygen free radicals (OFRs) is caused by an imbalance of the production of versus the antioxidant defenses against OFRs. METHODS: To understand hepatic damage induced by oxygen free radicals after hepatectomy in rats, total antioxidant status and total production of oxygen free radicals were serially measured in regeneration liver. At 1, 2, 3, 7, and 10 days after hepatectomy of Sprague-Dawley rats, blood was obtained into a capillary tube from a tail vein. Total antioxidant status and total production of oxygen free radicals were measured using the Randox kit, a colorimetric method, and the Free Radical Analytical System. We also measured the amount of malonyldialdehyde, which provides an indirect index of oxidative injury. RESULTS: The level of malonyldialdehyde after hepatectomy was higher compared with that before hepatectomy. The level of total oxygen free radicals after hepatectomy was higher compared with that before hepatectomy. Total antioxidant status after hepatectomy was lower compared with that before hepatectomy. CONCLUSIONS: The results suggested that the damage by OFRs to the regenerating liver was caused by increased production of OFRs and decreased antioxidant defense against OFRs. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/16980046/Total_antioxidant_status_and_oxygen_free_radicals_during_hepatic_regeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(06)00852-9 DB - PRIME DP - Unbound Medicine ER -