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Small dense low-density lipoprotein in renal transplant recipients: a potential target for prevention of cardiovascular complications?
Transplant Proc. 2006 Sep; 38(7):2314-6.TP

Abstract

BACKGROUND

Immunosuppressive therapy is frequently associated with dyslipidemia, which is involved in cardiovascular morbidity and mortality in transplant patients. Beyond classical factors, such as low-density lipoprotein (LDL) cholesterol (LDL-C), qualitative abnormalities of lipoproteins, such as presence of the atherogenic factor, small dense LDL, may be of interest for a cardiovascular risk assessment. This study was designed to explore LDL size in renal transplant recipients in relation to quantitative lipid parameters and apolipoprotein (apo) CIII polymorphism.

METHODS

Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), LDL-C, apoA1, apoB, apoCIII, and LDL size were measured in 62 patients of mean age 45 +/- 13 years including 71% men at 2 +/- 0.5 years after renal transplantation. Thirty-two patients received cyclosporine (CsA), while 30 received tacrolimus (FK). ApoCIII Sstl genotype was determined by restriction fragment length polymorphism.

RESULTS

The CsA group exhibited higher TC (P = .001), LDL-C (P = .004), non-HDL-C (P = .009), HDL-C (P = .03), apoB (P = .008), and apoCIII (P = .002) levels than the FK group. However, LDL-C (CsA: 3.7 +/- 1.2, FK: 3.0 +/- 0.6 mmol/L) and triglyceride levels (CsA: 1.55 mmol/L, FK: 1.37 mmol/L) were near the normal range in both groups. Allelic frequency of the sparse A2 allele associated with hypertriglyceridemia was 6%, similar to the general population. LDL size, which was comparable in the CsA and FK groups (25.87 +/- 0.89 vs 25.75 +/- 0.62 nm, respectively), inversely correlated with TG/HDL ratio (P = 10(-4)). Prevalence of small dense LDL (defined as <25.5 nm) was 26% in the CsA group and 33% in the FK group.

CONCLUSION

After LDL-C goal has been achieved, LDL size modulation may be taken into account in order to prevent cardiovascular complications.

Authors+Show Affiliations

Biochemistry Laboratory, Hôpital Lapeyronie, University of Montpellier Medical School, 371 avenue du doyen Gaston Giraud, 34295 Montpellier 05, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16980076

Citation

Badiou, S, et al. "Small Dense Low-density Lipoprotein in Renal Transplant Recipients: a Potential Target for Prevention of Cardiovascular Complications?" Transplantation Proceedings, vol. 38, no. 7, 2006, pp. 2314-6.
Badiou S, Garrigue V, Dupuy AM, et al. Small dense low-density lipoprotein in renal transplant recipients: a potential target for prevention of cardiovascular complications? Transplant Proc. 2006;38(7):2314-6.
Badiou, S., Garrigue, V., Dupuy, A. M., Chong, G., Cristol, J. P., & Mourad, G. (2006). Small dense low-density lipoprotein in renal transplant recipients: a potential target for prevention of cardiovascular complications? Transplantation Proceedings, 38(7), 2314-6.
Badiou S, et al. Small Dense Low-density Lipoprotein in Renal Transplant Recipients: a Potential Target for Prevention of Cardiovascular Complications. Transplant Proc. 2006;38(7):2314-6. PubMed PMID: 16980076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Small dense low-density lipoprotein in renal transplant recipients: a potential target for prevention of cardiovascular complications? AU - Badiou,S, AU - Garrigue,V, AU - Dupuy,A M, AU - Chong,G, AU - Cristol,J P, AU - Mourad,G, PY - 2006/9/19/pubmed PY - 2006/12/12/medline PY - 2006/9/19/entrez SP - 2314 EP - 6 JF - Transplantation proceedings JO - Transplant. Proc. VL - 38 IS - 7 N2 - BACKGROUND: Immunosuppressive therapy is frequently associated with dyslipidemia, which is involved in cardiovascular morbidity and mortality in transplant patients. Beyond classical factors, such as low-density lipoprotein (LDL) cholesterol (LDL-C), qualitative abnormalities of lipoproteins, such as presence of the atherogenic factor, small dense LDL, may be of interest for a cardiovascular risk assessment. This study was designed to explore LDL size in renal transplant recipients in relation to quantitative lipid parameters and apolipoprotein (apo) CIII polymorphism. METHODS: Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), LDL-C, apoA1, apoB, apoCIII, and LDL size were measured in 62 patients of mean age 45 +/- 13 years including 71% men at 2 +/- 0.5 years after renal transplantation. Thirty-two patients received cyclosporine (CsA), while 30 received tacrolimus (FK). ApoCIII Sstl genotype was determined by restriction fragment length polymorphism. RESULTS: The CsA group exhibited higher TC (P = .001), LDL-C (P = .004), non-HDL-C (P = .009), HDL-C (P = .03), apoB (P = .008), and apoCIII (P = .002) levels than the FK group. However, LDL-C (CsA: 3.7 +/- 1.2, FK: 3.0 +/- 0.6 mmol/L) and triglyceride levels (CsA: 1.55 mmol/L, FK: 1.37 mmol/L) were near the normal range in both groups. Allelic frequency of the sparse A2 allele associated with hypertriglyceridemia was 6%, similar to the general population. LDL size, which was comparable in the CsA and FK groups (25.87 +/- 0.89 vs 25.75 +/- 0.62 nm, respectively), inversely correlated with TG/HDL ratio (P = 10(-4)). Prevalence of small dense LDL (defined as <25.5 nm) was 26% in the CsA group and 33% in the FK group. CONCLUSION: After LDL-C goal has been achieved, LDL size modulation may be taken into account in order to prevent cardiovascular complications. SN - 0041-1345 UR - https://www.unboundmedicine.com/medline/citation/16980076/Small_dense_low_density_lipoprotein_in_renal_transplant_recipients:_a_potential_target_for_prevention_of_cardiovascular_complications L2 - https://linkinghub.elsevier.com/retrieve/pii/S0041-1345(06)00783-4 DB - PRIME DP - Unbound Medicine ER -