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Serum lipoprotein(a) dynamics before/after menopause and long-term effects of hormone replacement therapy on lipoprotein(a) levels in middle-aged and older Japanese women.
Horm Metab Res. 2006 Sep; 38(9):581-6.HM

Abstract

AIM

To assess lipoprotein(a) Lp(a) dynamics before and after menopause and to examine long-term changes during hormone replacement therapy (HRT) in middle-aged and older Japanese women.

METHODS

(1) Serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and Lp(a) concentrations of 526 patients were compared. The patients were divided into 3 groups on the basis of menopausal status (premenopause, perimenopause, postmenopause). (2) Serum markers of lipid metabolism were measured at baseline and at 6-month intervals in 161 postmenopausal women who continuously received HRT with conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA) for 4 years. (3) Changes in serum concentrations of markers were compared among 120 women with hypercholesterolemia who were randomly assigned to receive HRT (CEE plus MPA, or transdermal estradiol plus MPA) or pravastatin.

RESULTS

(1) Lp(a) concentrations were significantly higher in the postmenopausal women than in the premenopausal or perimenopausal women. (2) The mean Lp(a) concentration after 6 months of HRT decreased by about 19%, and similar levels were maintained for 4 years (3). The mean Lp(a) concentration after 6 months of HRT decreased by 19.9% in the CEE plus MPA group, but did not change significantly in the transdermal estradiol plus MPA group or the pravastatin group.

CONCLUSION

Our results suggest that HRT with CEE plus MPA is useful for the management of elevated serum Lp(a) concentrations in middle-aged and older women. However, follow-up studies are needed to determine whether this finding is related to the future prevention of coronary heart disease events.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Inagi City Hospital, Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16981140

Citation

Ushioda, M, et al. "Serum Lipoprotein(a) Dynamics Before/after Menopause and Long-term Effects of Hormone Replacement Therapy On Lipoprotein(a) Levels in Middle-aged and Older Japanese Women." Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, vol. 38, no. 9, 2006, pp. 581-6.
Ushioda M, Makita K, Takamatsu K, et al. Serum lipoprotein(a) dynamics before/after menopause and long-term effects of hormone replacement therapy on lipoprotein(a) levels in middle-aged and older Japanese women. Horm Metab Res. 2006;38(9):581-6.
Ushioda, M., Makita, K., Takamatsu, K., Horiguchi, F., & Aoki, D. (2006). Serum lipoprotein(a) dynamics before/after menopause and long-term effects of hormone replacement therapy on lipoprotein(a) levels in middle-aged and older Japanese women. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme, 38(9), 581-6.
Ushioda M, et al. Serum Lipoprotein(a) Dynamics Before/after Menopause and Long-term Effects of Hormone Replacement Therapy On Lipoprotein(a) Levels in Middle-aged and Older Japanese Women. Horm Metab Res. 2006;38(9):581-6. PubMed PMID: 16981140.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum lipoprotein(a) dynamics before/after menopause and long-term effects of hormone replacement therapy on lipoprotein(a) levels in middle-aged and older Japanese women. AU - Ushioda,M, AU - Makita,K, AU - Takamatsu,K, AU - Horiguchi,F, AU - Aoki,D, PY - 2006/9/19/pubmed PY - 2009/3/26/medline PY - 2006/9/19/entrez SP - 581 EP - 6 JF - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme JO - Horm Metab Res VL - 38 IS - 9 N2 - AIM: To assess lipoprotein(a) Lp(a) dynamics before and after menopause and to examine long-term changes during hormone replacement therapy (HRT) in middle-aged and older Japanese women. METHODS: (1) Serum total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and Lp(a) concentrations of 526 patients were compared. The patients were divided into 3 groups on the basis of menopausal status (premenopause, perimenopause, postmenopause). (2) Serum markers of lipid metabolism were measured at baseline and at 6-month intervals in 161 postmenopausal women who continuously received HRT with conjugated equine estrogen (CEE) and medroxyprogesterone acetate (MPA) for 4 years. (3) Changes in serum concentrations of markers were compared among 120 women with hypercholesterolemia who were randomly assigned to receive HRT (CEE plus MPA, or transdermal estradiol plus MPA) or pravastatin. RESULTS: (1) Lp(a) concentrations were significantly higher in the postmenopausal women than in the premenopausal or perimenopausal women. (2) The mean Lp(a) concentration after 6 months of HRT decreased by about 19%, and similar levels were maintained for 4 years (3). The mean Lp(a) concentration after 6 months of HRT decreased by 19.9% in the CEE plus MPA group, but did not change significantly in the transdermal estradiol plus MPA group or the pravastatin group. CONCLUSION: Our results suggest that HRT with CEE plus MPA is useful for the management of elevated serum Lp(a) concentrations in middle-aged and older women. However, follow-up studies are needed to determine whether this finding is related to the future prevention of coronary heart disease events. SN - 1439-4286 UR - https://www.unboundmedicine.com/medline/citation/16981140/Serum_lipoprotein_a__dynamics_before/after_menopause_and_long_term_effects_of_hormone_replacement_therapy_on_lipoprotein_a__levels_in_middle_aged_and_older_Japanese_women_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2006-950504 DB - PRIME DP - Unbound Medicine ER -