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Prothrombin A19911G polymorphism and the risk of venous thromboembolism.
J Thromb Haemost. 2006 Dec; 4(12):2582-6.JT

Abstract

BACKGROUND

The A > G polymorphism at position 19911 of the prothrombin gene is associated with increased plasma prothrombin levels but its role as a risk factor for venous thromboembolism (VTE) is not established.

OBJECTIVE

To investigate the role of prothrombin 19911 A > G polymorphism in the risk of VTE in patients with heterozygous prothrombin 20210GA or factor (F) V Leiden and in those without thrombophilia.

PATIENTS AND METHODS

Case-control study of 793 patients with prothrombin 20210 GA (n = 167) or FV Leiden (n = 198), and without thrombophilia (n = 428), and of 795 healthy individuals with the corresponding coagulation profile, investigated for the presence of prothrombin 19911 A > G. Plasma prothrombin levels were measured in 342 individuals.

RESULTS

Prothrombin 19911 A > G did not increase the risk of VTE in carriers of prothrombin 20210 GA [odds ratio (OR) 1.2, 95% CI (95% CI) 0.8-1.8] but significantly increased the risk in carriers of FV Leiden (OR 2.1, 95% CI 1.3-3.4) and in patients without thrombophilia (OR 1.5, 95% CI 1.0-2.2). Higher plasma prothrombin levels in carriers of prothrombin 19911 A > G polymorphism than in non-carriers were found among individuals without thrombophilia (P =0.05) and with FV Leiden (P = 0.07), but not in carriers of prothrombin 20210 GA (P = 0.2).

CONCLUSIONS

Prothrombin 19911 A > G polymorphism was independently associated with a 1.5-fold increased risk of VTE and increased 2-fold the risk of VTE associated with FV Leiden, both increases statistically significant. No effect was observed in carriers of prothrombin 20210 GA, perhaps because this polymorphism has a stronger influence on plasma prothrombin levels than the prothrombin 19911 polymorphism.

Authors+Show Affiliations

Department of Internal Medicine and Medical Specialties, A. Bianchi Bonomi Haemophilia and Thrombosis Center, University of Milan, and IRCCS Ospedale Maggiore Policlinico, Mangiagalli and Regina Elena Foundation, Milan, Italy. martin@policlinico.mi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

16981886

Citation

Martinelli, I, et al. "Prothrombin A19911G Polymorphism and the Risk of Venous Thromboembolism." Journal of Thrombosis and Haemostasis : JTH, vol. 4, no. 12, 2006, pp. 2582-6.
Martinelli I, Battaglioli T, Tosetto A, et al. Prothrombin A19911G polymorphism and the risk of venous thromboembolism. J Thromb Haemost. 2006;4(12):2582-6.
Martinelli, I., Battaglioli, T., Tosetto, A., Legnani, C., Sottile, L., Ghiotto, R., & Mannucci, P. M. (2006). Prothrombin A19911G polymorphism and the risk of venous thromboembolism. Journal of Thrombosis and Haemostasis : JTH, 4(12), 2582-6.
Martinelli I, et al. Prothrombin A19911G Polymorphism and the Risk of Venous Thromboembolism. J Thromb Haemost. 2006;4(12):2582-6. PubMed PMID: 16981886.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prothrombin A19911G polymorphism and the risk of venous thromboembolism. AU - Martinelli,I, AU - Battaglioli,T, AU - Tosetto,A, AU - Legnani,C, AU - Sottile,L, AU - Ghiotto,R, AU - Mannucci,P M, Y1 - 2006/09/15/ PY - 2006/9/20/pubmed PY - 2007/1/9/medline PY - 2006/9/20/entrez SP - 2582 EP - 6 JF - Journal of thrombosis and haemostasis : JTH JO - J Thromb Haemost VL - 4 IS - 12 N2 - BACKGROUND: The A > G polymorphism at position 19911 of the prothrombin gene is associated with increased plasma prothrombin levels but its role as a risk factor for venous thromboembolism (VTE) is not established. OBJECTIVE: To investigate the role of prothrombin 19911 A > G polymorphism in the risk of VTE in patients with heterozygous prothrombin 20210GA or factor (F) V Leiden and in those without thrombophilia. PATIENTS AND METHODS: Case-control study of 793 patients with prothrombin 20210 GA (n = 167) or FV Leiden (n = 198), and without thrombophilia (n = 428), and of 795 healthy individuals with the corresponding coagulation profile, investigated for the presence of prothrombin 19911 A > G. Plasma prothrombin levels were measured in 342 individuals. RESULTS: Prothrombin 19911 A > G did not increase the risk of VTE in carriers of prothrombin 20210 GA [odds ratio (OR) 1.2, 95% CI (95% CI) 0.8-1.8] but significantly increased the risk in carriers of FV Leiden (OR 2.1, 95% CI 1.3-3.4) and in patients without thrombophilia (OR 1.5, 95% CI 1.0-2.2). Higher plasma prothrombin levels in carriers of prothrombin 19911 A > G polymorphism than in non-carriers were found among individuals without thrombophilia (P =0.05) and with FV Leiden (P = 0.07), but not in carriers of prothrombin 20210 GA (P = 0.2). CONCLUSIONS: Prothrombin 19911 A > G polymorphism was independently associated with a 1.5-fold increased risk of VTE and increased 2-fold the risk of VTE associated with FV Leiden, both increases statistically significant. No effect was observed in carriers of prothrombin 20210 GA, perhaps because this polymorphism has a stronger influence on plasma prothrombin levels than the prothrombin 19911 polymorphism. SN - 1538-7933 UR - https://www.unboundmedicine.com/medline/citation/16981886/Prothrombin_A19911G_polymorphism_and_the_risk_of_venous_thromboembolism_ L2 - https://doi.org/10.1111/j.1538-7836.2006.02216.x DB - PRIME DP - Unbound Medicine ER -