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Effects of sarin and cyclosarin exposure during the 1991 Gulf War on neurobehavioral functioning in US army veterans.
Neurotoxicology. 2006 Dec; 27(6):931-9.N

Abstract

BACKGROUND

During the Gulf War (GW), in early March 1991, a munitions dump at Khamisiyah, Iraq, was destroyed. Later, in 1996, the dump was found to have contained the organophosphate chemical warfare agents, sarin and cyclosarin.

METHODS

Data collected in a study conducted between 1994 and 1996, before the Khamisiyah incident was publicly disclosed, were used to examine neurobehavioral task performances of GW veterans (n=140) categorized as having received high, moderate, or low-to-no exposure dose levels to sarin and cyclosarin at Khamisiyah, Iraq. Exposure levels were based on modeled estimates of the exposure plume and on troop location information at the time of the Khamisiyah event. Based on recent findings observed in follow-up studies of persons exposed to sarin during the 1995 terrorist attacks in Japan, we hypothesized that exposure to sarin and cyclosarin would be associated with poorer performances on objective neurobehavioral tasks in specific functional domains (particularly in visuospatial abilities and psychomotor functioning) in a dose-dependent manner.

RESULTS

Sarin and cyclosarin exposure was significantly associated with less proficient neurobehavioral functioning on tasks involving fine psychomotor dexterity and visuospatial abilities 4-5 years after exposure.

CONCLUSIONS

Findings suggest a dose-response association between low-level exposure to sarin and cyclosarin and specific functional central nervous system effects 4-5 years after exposure.

Authors+Show Affiliations

Boston Environmental Hazards Center, VA Boston Healthcare System, Boston, MA 02130-4893, USA. sproctor@bu.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

16982099

Citation

Proctor, Susan P., et al. "Effects of Sarin and Cyclosarin Exposure During the 1991 Gulf War On Neurobehavioral Functioning in US Army Veterans." Neurotoxicology, vol. 27, no. 6, 2006, pp. 931-9.
Proctor SP, Heaton KJ, Heeren T, et al. Effects of sarin and cyclosarin exposure during the 1991 Gulf War on neurobehavioral functioning in US army veterans. Neurotoxicology. 2006;27(6):931-9.
Proctor, S. P., Heaton, K. J., Heeren, T., & White, R. F. (2006). Effects of sarin and cyclosarin exposure during the 1991 Gulf War on neurobehavioral functioning in US army veterans. Neurotoxicology, 27(6), 931-9.
Proctor SP, et al. Effects of Sarin and Cyclosarin Exposure During the 1991 Gulf War On Neurobehavioral Functioning in US Army Veterans. Neurotoxicology. 2006;27(6):931-9. PubMed PMID: 16982099.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of sarin and cyclosarin exposure during the 1991 Gulf War on neurobehavioral functioning in US army veterans. AU - Proctor,Susan P, AU - Heaton,Kristin J, AU - Heeren,Tim, AU - White,Roberta F, Y1 - 2006/08/07/ PY - 2006/05/26/received PY - 2006/08/02/revised PY - 2006/08/02/accepted PY - 2006/9/20/pubmed PY - 2007/3/22/medline PY - 2006/9/20/entrez SP - 931 EP - 9 JF - Neurotoxicology JO - Neurotoxicology VL - 27 IS - 6 N2 - BACKGROUND: During the Gulf War (GW), in early March 1991, a munitions dump at Khamisiyah, Iraq, was destroyed. Later, in 1996, the dump was found to have contained the organophosphate chemical warfare agents, sarin and cyclosarin. METHODS: Data collected in a study conducted between 1994 and 1996, before the Khamisiyah incident was publicly disclosed, were used to examine neurobehavioral task performances of GW veterans (n=140) categorized as having received high, moderate, or low-to-no exposure dose levels to sarin and cyclosarin at Khamisiyah, Iraq. Exposure levels were based on modeled estimates of the exposure plume and on troop location information at the time of the Khamisiyah event. Based on recent findings observed in follow-up studies of persons exposed to sarin during the 1995 terrorist attacks in Japan, we hypothesized that exposure to sarin and cyclosarin would be associated with poorer performances on objective neurobehavioral tasks in specific functional domains (particularly in visuospatial abilities and psychomotor functioning) in a dose-dependent manner. RESULTS: Sarin and cyclosarin exposure was significantly associated with less proficient neurobehavioral functioning on tasks involving fine psychomotor dexterity and visuospatial abilities 4-5 years after exposure. CONCLUSIONS: Findings suggest a dose-response association between low-level exposure to sarin and cyclosarin and specific functional central nervous system effects 4-5 years after exposure. SN - 0161-813X UR - https://www.unboundmedicine.com/medline/citation/16982099/Effects_of_sarin_and_cyclosarin_exposure_during_the_1991_Gulf_War_on_neurobehavioral_functioning_in_US_army_veterans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-813X(06)00192-6 DB - PRIME DP - Unbound Medicine ER -