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Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases.
J Neuroimmunol. 2006 Jul; 176(1-2):198-215.JN

Abstract

Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic neuron depletion; ALS, a disease of motor neuron death; and Alzheimer's, a disease of plaques and tangles. Although these disorders differ in important ways, they also have common pathogenic features, including inflammation, genetic mutations, inappropriate protein aggregates (e.g., Lewy bodies, amyloid plaques), and biochemical defects leading to apoptosis, such as oxidative stress and mitochondrial dysfunction. In most disorders, it remains uncertain whether inflammation and protein aggregation are neurotoxic or neuroprotective. Elucidating the mechanisms that orchestrate neuronal diseases should facilitate development of neuroprotective and neurorestorative strategies.

Authors+Show Affiliations

UMDNJ-Robert Wood Johnson Medical School, New Brunswick, NJ 08901, and The Cleveland Clinic, OH, USA. jalbutsu@umdnj.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Conference
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16983747

Citation

Dhib-Jalbut, Suhayl, et al. "Neurodegeneration and Neuroprotection in Multiple Sclerosis and Other Neurodegenerative Diseases." Journal of Neuroimmunology, vol. 176, no. 1-2, 2006, pp. 198-215.
Dhib-Jalbut S, Arnold DL, Cleveland DW, et al. Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. J Neuroimmunol. 2006;176(1-2):198-215.
Dhib-Jalbut, S., Arnold, D. L., Cleveland, D. W., Fisher, M., Friedlander, R. M., Mouradian, M. M., Przedborski, S., Trapp, B. D., Wyss-Coray, T., & Yong, V. W. (2006). Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. Journal of Neuroimmunology, 176(1-2), 198-215.
Dhib-Jalbut S, et al. Neurodegeneration and Neuroprotection in Multiple Sclerosis and Other Neurodegenerative Diseases. J Neuroimmunol. 2006;176(1-2):198-215. PubMed PMID: 16983747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurodegeneration and neuroprotection in multiple sclerosis and other neurodegenerative diseases. AU - Dhib-Jalbut,Suhayl, AU - Arnold,Douglas L, AU - Cleveland,Don W, AU - Fisher,Mark, AU - Friedlander,Robert M, AU - Mouradian,M Maral, AU - Przedborski,Serge, AU - Trapp,Bruce D, AU - Wyss-Coray,Tony, AU - Yong,V Wee, PY - 2006/9/20/pubmed PY - 2006/9/30/medline PY - 2006/9/20/entrez SP - 198 EP - 215 JF - Journal of neuroimmunology JO - J. Neuroimmunol. VL - 176 IS - 1-2 N2 - Multiple sclerosis is considered a disease of myelin destruction; Parkinson's disease (PD), one of dopaminergic neuron depletion; ALS, a disease of motor neuron death; and Alzheimer's, a disease of plaques and tangles. Although these disorders differ in important ways, they also have common pathogenic features, including inflammation, genetic mutations, inappropriate protein aggregates (e.g., Lewy bodies, amyloid plaques), and biochemical defects leading to apoptosis, such as oxidative stress and mitochondrial dysfunction. In most disorders, it remains uncertain whether inflammation and protein aggregation are neurotoxic or neuroprotective. Elucidating the mechanisms that orchestrate neuronal diseases should facilitate development of neuroprotective and neurorestorative strategies. SN - 0165-5728 UR - https://www.unboundmedicine.com/medline/citation/16983747/Neurodegeneration_and_neuroprotection_in_multiple_sclerosis_and_other_neurodegenerative_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(06)00128-7 DB - PRIME DP - Unbound Medicine ER -