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Increased permeability for polyethylene glycols through skin compromised by sodium lauryl sulphate.
Exp Dermatol. 2006 Oct; 15(10):801-7.ED

Abstract

In this in vivo human study we assessed the influence of skin damage by sodium lauryl sulphate (SLS) on percutaneous penetration of polyethylene glycols (PEGs) of different molecular weights (MW). Percutaneous penetration of PEGs was determined using tape stripping of the stratum corneum (SC). The forearm skin of volunteers was pretreated with 5% w/w SLS for 4 h, and 24 h later patches with PEGs were applied for 6 h. The penetration parameters were deduced by data regression to Fick's law for unsteady-state diffusion. The trans-epidermal water loss (TEWL) increased after SLS treatment from 6.3 +/- 2.1 to 17.9 +/- 8.7 g/m(2)/h. The diffusion coefficient for all PEGs was increased in the SLS-damaged skin. The increase was smaller for higher MW. In addition, the partition coefficient of PEGs between SC and water was larger in the SLS-compromised skin and showed a tendency to increase with MW. The permeability coefficient decreased gradually with increasing MW of PEGs in both control and SLS-compromised skin. SLS caused a threefold increase in the permeability coefficient for all MWs ranging in control skin from 0.34 to 0.70 x 10(-5) cm/h and in the SLS-compromised skin from 1.20 to 2.09 x 10(-5) cm/h for MW of 590-282 Da. The results of this study show the deleterious effect of SLS on the skin barrier for hydrophilic PEGs. A defective skin barrier will facilitate absorption of other chemicals and local skin effects.

Authors+Show Affiliations

Jakasa I
Coronel Institute of Occupational Health, Academic Medical Center, Universiteit van Amsterdam, 1100 DE Amsterdam, The Netherlands. i.jakasa@amc.uva.nl
Verberk MM
No affiliation info available
Bunge AL
No affiliation info available
Kruse J
No affiliation info available
Kezic S
No affiliation info available

MeSH

AdolescentAdultCell Membrane PermeabilityDermatitis, AtopicFemaleHumansMaleMiddle AgedPolyethylene GlycolsSkinSkin AbsorptionSodium Dodecyl SulfateSurface-Active Agents

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16984262

Citation

Jakasa, Ivone, et al. "Increased Permeability for Polyethylene Glycols Through Skin Compromised By Sodium Lauryl Sulphate." Experimental Dermatology, vol. 15, no. 10, 2006, pp. 801-7.
Jakasa I, Verberk MM, Bunge AL, et al. Increased permeability for polyethylene glycols through skin compromised by sodium lauryl sulphate. Exp Dermatol. 2006;15(10):801-7.
Jakasa, I., Verberk, M. M., Bunge, A. L., Kruse, J., & Kezic, S. (2006). Increased permeability for polyethylene glycols through skin compromised by sodium lauryl sulphate. Experimental Dermatology, 15(10), 801-7.
Jakasa I, et al. Increased Permeability for Polyethylene Glycols Through Skin Compromised By Sodium Lauryl Sulphate. Exp Dermatol. 2006;15(10):801-7. PubMed PMID: 16984262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased permeability for polyethylene glycols through skin compromised by sodium lauryl sulphate. AU - Jakasa,Ivone, AU - Verberk,Maarten M, AU - Bunge,Annette L, AU - Kruse,Jacob, AU - Kezic,Sanja, PY - 2006/9/21/pubmed PY - 2006/12/12/medline PY - 2006/9/21/entrez SP - 801 EP - 7 JF - Experimental dermatology JO - Exp Dermatol VL - 15 IS - 10 N2 - In this in vivo human study we assessed the influence of skin damage by sodium lauryl sulphate (SLS) on percutaneous penetration of polyethylene glycols (PEGs) of different molecular weights (MW). Percutaneous penetration of PEGs was determined using tape stripping of the stratum corneum (SC). The forearm skin of volunteers was pretreated with 5% w/w SLS for 4 h, and 24 h later patches with PEGs were applied for 6 h. The penetration parameters were deduced by data regression to Fick's law for unsteady-state diffusion. The trans-epidermal water loss (TEWL) increased after SLS treatment from 6.3 +/- 2.1 to 17.9 +/- 8.7 g/m(2)/h. The diffusion coefficient for all PEGs was increased in the SLS-damaged skin. The increase was smaller for higher MW. In addition, the partition coefficient of PEGs between SC and water was larger in the SLS-compromised skin and showed a tendency to increase with MW. The permeability coefficient decreased gradually with increasing MW of PEGs in both control and SLS-compromised skin. SLS caused a threefold increase in the permeability coefficient for all MWs ranging in control skin from 0.34 to 0.70 x 10(-5) cm/h and in the SLS-compromised skin from 1.20 to 2.09 x 10(-5) cm/h for MW of 590-282 Da. The results of this study show the deleterious effect of SLS on the skin barrier for hydrophilic PEGs. A defective skin barrier will facilitate absorption of other chemicals and local skin effects. SN - 0906-6705 UR - https://www.unboundmedicine.com/medline/citation/16984262/Increased_permeability_for_polyethylene_glycols_through_skin_compromised_by_sodium_lauryl_sulphate_ DB - PRIME DP - Unbound Medicine ER -