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Absence of human herpesvirus-8 and Epstein-Barr virus in inflammatory myofibroblastic tumor with anaplastic large cell lymphoma kinase fusion gene.
Pathol Int 2006; 56(10):584-90PI

Abstract

Inflammatory myofibroblastic tumor (IMT) is clinically and histologically characterized by inflammation. Some populations of IMT have anaplastic large cell lymphoma kinase (ALK) gene rearrangements. Infection with Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV-8) in tumor cells of IMT has been reported; these reports, however, have been limited to ALK-negative IMT. The purpose of the present paper was to evaluate 21 cases of IMT for the presence of EBV and HHV-8. Immunohistochemically, 15 cases were ALK positive and six were negative. Of eight cases analyzed using reverse transcription-polymerase chain reaction, tropomyosin 3 (TPM3)-ALK, TPM4-ALK and clathrin heavy chain-ALK fusion genes were detected in one, two and two cases, respectively. All 21 IMT, irrespective of ALK expression, were negative for EBV by in situ hybridization for EBV-encoded RNA and immunohistochemical stain for latent membrane antigen-1. HHV-8 was also negative in all IMT by PCR for HHV-8 DNA sequence (KS330/233) and immunohistochemical stain for latent nuclear antigen. These results suggest that IMT may be a heterogeneous group in terms of pathogenesis, and EBV and HHV-8 do not play a major role in the pathogenesis of ALK-positive tumor.

Authors+Show Affiliations

Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. hidetaka@surgpath.med.kyushu-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Studies
Journal Article

Language

eng

PubMed ID

16984614

Citation

Yamamoto, Hidetaka, et al. "Absence of Human Herpesvirus-8 and Epstein-Barr Virus in Inflammatory Myofibroblastic Tumor With Anaplastic Large Cell Lymphoma Kinase Fusion Gene." Pathology International, vol. 56, no. 10, 2006, pp. 584-90.
Yamamoto H, Kohashi K, Oda Y, et al. Absence of human herpesvirus-8 and Epstein-Barr virus in inflammatory myofibroblastic tumor with anaplastic large cell lymphoma kinase fusion gene. Pathol Int. 2006;56(10):584-90.
Yamamoto, H., Kohashi, K., Oda, Y., Tamiya, S., Takahashi, Y., Kinoshita, Y., ... Tsuneyoshi, M. (2006). Absence of human herpesvirus-8 and Epstein-Barr virus in inflammatory myofibroblastic tumor with anaplastic large cell lymphoma kinase fusion gene. Pathology International, 56(10), pp. 584-90.
Yamamoto H, et al. Absence of Human Herpesvirus-8 and Epstein-Barr Virus in Inflammatory Myofibroblastic Tumor With Anaplastic Large Cell Lymphoma Kinase Fusion Gene. Pathol Int. 2006;56(10):584-90. PubMed PMID: 16984614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Absence of human herpesvirus-8 and Epstein-Barr virus in inflammatory myofibroblastic tumor with anaplastic large cell lymphoma kinase fusion gene. AU - Yamamoto,Hidetaka, AU - Kohashi,Kenichi, AU - Oda,Yoshinao, AU - Tamiya,Sadafumi, AU - Takahashi,Yukiko, AU - Kinoshita,Yoshiaki, AU - Ishizawa,Shin, AU - Kubota,Masayuki, AU - Tsuneyoshi,Masazumi, PY - 2006/9/21/pubmed PY - 2006/12/21/medline PY - 2006/9/21/entrez SP - 584 EP - 90 JF - Pathology international JO - Pathol. Int. VL - 56 IS - 10 N2 - Inflammatory myofibroblastic tumor (IMT) is clinically and histologically characterized by inflammation. Some populations of IMT have anaplastic large cell lymphoma kinase (ALK) gene rearrangements. Infection with Epstein-Barr virus (EBV) and human herpesvirus-8 (HHV-8) in tumor cells of IMT has been reported; these reports, however, have been limited to ALK-negative IMT. The purpose of the present paper was to evaluate 21 cases of IMT for the presence of EBV and HHV-8. Immunohistochemically, 15 cases were ALK positive and six were negative. Of eight cases analyzed using reverse transcription-polymerase chain reaction, tropomyosin 3 (TPM3)-ALK, TPM4-ALK and clathrin heavy chain-ALK fusion genes were detected in one, two and two cases, respectively. All 21 IMT, irrespective of ALK expression, were negative for EBV by in situ hybridization for EBV-encoded RNA and immunohistochemical stain for latent membrane antigen-1. HHV-8 was also negative in all IMT by PCR for HHV-8 DNA sequence (KS330/233) and immunohistochemical stain for latent nuclear antigen. These results suggest that IMT may be a heterogeneous group in terms of pathogenesis, and EBV and HHV-8 do not play a major role in the pathogenesis of ALK-positive tumor. SN - 1320-5463 UR - https://www.unboundmedicine.com/medline/citation/16984614/Absence_of_human_herpesvirus_8_and_Epstein_Barr_virus_in_inflammatory_myofibroblastic_tumor_with_anaplastic_large_cell_lymphoma_kinase_fusion_gene_ L2 - https://doi.org/10.1111/j.1440-1827.2006.02012.x DB - PRIME DP - Unbound Medicine ER -