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Maternal supplement, micronutrient, and cured meat intake during pregnancy and risk of medulloblastoma during childhood: a children's oncology group study.
Cancer Epidemiol Biomarkers Prev. 2006 Sep; 15(9):1660-7.CE

Abstract

We conducted a case-control study of medulloblastoma/primitive neuroectodermal tumors of brain (PNET) to pursue findings related to vitamin and mineral supplements, micronutrients, and cured meat consumption during gestation. Mothers of 315 cases ages <6 years at diagnosis in 1991 to 1997 identified from the United States and Canada through the Children's Oncology Group and mothers of 315 controls selected by random-digit dialing were interviewed. In the periconception period of the index pregnancy, case mothers were less likely than control mothers to report use of multivitamins [adjusted odds ratio (OR), 0.7; 95% confidence interval (95% CI), 0.4-1.0; P = 0.08] and to be in the highest quartile of iron and folate intake from food and supplements combined (adjusted OR for iron, 0.5; 95% CI, 0.3-0.9; P(trend) = 0.008; adjusted OR for folate, 0.5; 95% CI, 0.3-0.9; P(trend) = 0.007). Case and control mothers had similar intakes of cured meats, although case mothers were more likely to have the combination of high cured meat and low vitamin C intake (OR, 1.5; 95% CI, 1.0-2.3; P = 0.08). The results of the study add to the evidence of a protective role for multivitamins, suggest a possible role for micronutrients early in pregnancy, and generally do not support an association between cured meats and medulloblastoma/PNET.

Authors+Show Affiliations

c/o Donna Correia, CureSearch, Children's Oncology Group, 440 East Huntington Drive, Arcadia, CA 91006, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16985028

Citation

Bunin, Greta R., et al. "Maternal Supplement, Micronutrient, and Cured Meat Intake During Pregnancy and Risk of Medulloblastoma During Childhood: a Children's Oncology Group Study." Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, vol. 15, no. 9, 2006, pp. 1660-7.
Bunin GR, Gallagher PR, Rorke-Adams LB, et al. Maternal supplement, micronutrient, and cured meat intake during pregnancy and risk of medulloblastoma during childhood: a children's oncology group study. Cancer Epidemiol Biomarkers Prev. 2006;15(9):1660-7.
Bunin, G. R., Gallagher, P. R., Rorke-Adams, L. B., Robison, L. L., & Cnaan, A. (2006). Maternal supplement, micronutrient, and cured meat intake during pregnancy and risk of medulloblastoma during childhood: a children's oncology group study. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored By the American Society of Preventive Oncology, 15(9), 1660-7.
Bunin GR, et al. Maternal Supplement, Micronutrient, and Cured Meat Intake During Pregnancy and Risk of Medulloblastoma During Childhood: a Children's Oncology Group Study. Cancer Epidemiol Biomarkers Prev. 2006;15(9):1660-7. PubMed PMID: 16985028.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal supplement, micronutrient, and cured meat intake during pregnancy and risk of medulloblastoma during childhood: a children's oncology group study. AU - Bunin,Greta R, AU - Gallagher,Paul R, AU - Rorke-Adams,Lucy B, AU - Robison,Leslie L, AU - Cnaan,Avital, PY - 2006/9/21/pubmed PY - 2006/11/14/medline PY - 2006/9/21/entrez SP - 1660 EP - 7 JF - Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology JO - Cancer Epidemiol Biomarkers Prev VL - 15 IS - 9 N2 - We conducted a case-control study of medulloblastoma/primitive neuroectodermal tumors of brain (PNET) to pursue findings related to vitamin and mineral supplements, micronutrients, and cured meat consumption during gestation. Mothers of 315 cases ages <6 years at diagnosis in 1991 to 1997 identified from the United States and Canada through the Children's Oncology Group and mothers of 315 controls selected by random-digit dialing were interviewed. In the periconception period of the index pregnancy, case mothers were less likely than control mothers to report use of multivitamins [adjusted odds ratio (OR), 0.7; 95% confidence interval (95% CI), 0.4-1.0; P = 0.08] and to be in the highest quartile of iron and folate intake from food and supplements combined (adjusted OR for iron, 0.5; 95% CI, 0.3-0.9; P(trend) = 0.008; adjusted OR for folate, 0.5; 95% CI, 0.3-0.9; P(trend) = 0.007). Case and control mothers had similar intakes of cured meats, although case mothers were more likely to have the combination of high cured meat and low vitamin C intake (OR, 1.5; 95% CI, 1.0-2.3; P = 0.08). The results of the study add to the evidence of a protective role for multivitamins, suggest a possible role for micronutrients early in pregnancy, and generally do not support an association between cured meats and medulloblastoma/PNET. SN - 1055-9965 UR - https://www.unboundmedicine.com/medline/citation/16985028/Maternal_supplement_micronutrient_and_cured_meat_intake_during_pregnancy_and_risk_of_medulloblastoma_during_childhood:_a_children's_oncology_group_study_ L2 - http://cebp.aacrjournals.org/cgi/pmidlookup?view=long&amp;pmid=16985028 DB - PRIME DP - Unbound Medicine ER -