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Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings.
J Natl Cancer Inst 2006; 98(18):1275-84JNCI

Abstract

The impact of soyfood intake on breast cancer risk has been investigated extensively. Much of this focus can be attributed to the soybean being a dietary source that is uniquely rich in isoflavones. The chemical structure of isoflavones is similar to that of estrogen, and isoflavones bind to both estrogen receptors (ER alpha and ER beta) (although they preferentially bind to and activate ER beta) and exert estrogen-like effects under some experimental conditions. Isoflavones also possess nonhormonal properties that are associated with the inhibition of cancer cell growth. Thus, there are several possible mechanisms by which soy may reduce the risk of breast cancer. However, the role of isoflavones in breast cancer has become controversial because, in contrast to the possible beneficial effects, some data from in vitro and animal studies suggest that isoflavones, especially genistein, the aglycone of the main soybean isoflavone genistin, may stimulate the growth of estrogen-sensitive tumors. Limited human data directly address the tumor-promoting effects of isoflavones and soy. Because the use of soyfoods and isoflavone supplements is increasing, it is important from a public health perspective to understand the impact of these products on breast cancer risk in women at high risk of the disease and on the survival of breast cancer patients. To this end, a workshop was held in November 2005 to review the existing literature and to make research recommendations. This paper summarizes the workshop findings and recommendations. The primary research recommendation is that the impact of isoflavones on breast tissue needs to be evaluated at the cellular level in women at high risk for breast cancer.

Authors+Show Affiliations

Department of Nutrition, School of Public Health, Loma Linda University, Loma Linda, CA, USA. markm@olympus.netNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

16985246

Citation

Messina, Mark, et al. "Addressing the Soy and Breast Cancer Relationship: Review, Commentary, and Workshop Proceedings." Journal of the National Cancer Institute, vol. 98, no. 18, 2006, pp. 1275-84.
Messina M, McCaskill-Stevens W, Lampe JW. Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. J Natl Cancer Inst. 2006;98(18):1275-84.
Messina, M., McCaskill-Stevens, W., & Lampe, J. W. (2006). Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. Journal of the National Cancer Institute, 98(18), pp. 1275-84.
Messina M, McCaskill-Stevens W, Lampe JW. Addressing the Soy and Breast Cancer Relationship: Review, Commentary, and Workshop Proceedings. J Natl Cancer Inst. 2006 Sep 20;98(18):1275-84. PubMed PMID: 16985246.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Addressing the soy and breast cancer relationship: review, commentary, and workshop proceedings. AU - Messina,Mark, AU - McCaskill-Stevens,Worta, AU - Lampe,Johanna W, PY - 2006/9/21/pubmed PY - 2006/9/27/medline PY - 2006/9/21/entrez SP - 1275 EP - 84 JF - Journal of the National Cancer Institute JO - J. Natl. Cancer Inst. VL - 98 IS - 18 N2 - The impact of soyfood intake on breast cancer risk has been investigated extensively. Much of this focus can be attributed to the soybean being a dietary source that is uniquely rich in isoflavones. The chemical structure of isoflavones is similar to that of estrogen, and isoflavones bind to both estrogen receptors (ER alpha and ER beta) (although they preferentially bind to and activate ER beta) and exert estrogen-like effects under some experimental conditions. Isoflavones also possess nonhormonal properties that are associated with the inhibition of cancer cell growth. Thus, there are several possible mechanisms by which soy may reduce the risk of breast cancer. However, the role of isoflavones in breast cancer has become controversial because, in contrast to the possible beneficial effects, some data from in vitro and animal studies suggest that isoflavones, especially genistein, the aglycone of the main soybean isoflavone genistin, may stimulate the growth of estrogen-sensitive tumors. Limited human data directly address the tumor-promoting effects of isoflavones and soy. Because the use of soyfoods and isoflavone supplements is increasing, it is important from a public health perspective to understand the impact of these products on breast cancer risk in women at high risk of the disease and on the survival of breast cancer patients. To this end, a workshop was held in November 2005 to review the existing literature and to make research recommendations. This paper summarizes the workshop findings and recommendations. The primary research recommendation is that the impact of isoflavones on breast tissue needs to be evaluated at the cellular level in women at high risk for breast cancer. SN - 1460-2105 UR - https://www.unboundmedicine.com/medline/citation/16985246/Addressing_the_soy_and_breast_cancer_relationship:_review_commentary_and_workshop_proceedings_ L2 - https://academic.oup.com/jnci/article-lookup/doi/10.1093/jnci/djj356 DB - PRIME DP - Unbound Medicine ER -