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Influence of narrow-band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis.
J Eur Acad Dermatol Venereol. 2006 Oct; 20(9):1114-20.JE

Abstract

OBJECTIVE

In the present work, the effect of narrow-band ultraviolet B (UVB) phototherapy on a cutaneous microbial population was evaluated in patients with atopic dermatitis (AD) and compared with control patients (vitiligo).

METHODS

Count, isolation and identification of cutaneous microbiota from anticubital fossa were performed in 10 controls and 10 AD patients, both submitted to similar levels (P > 0.05) of UVB phototherapy (4.3 +/- 0.9 and 4.3 +/- 0.8 accumulated joules, respectively). Additionally, Staphylococcus aureus isolates were screened for the production of exotoxins.

RESULTS

The total and staphylococcal cutaneous microbial population levels were higher (P < 0.05) in AD patients than in the controls. All these population levels decreased (P < 0.05) for both AD and control patients after UVB phototherapy, which also decreased the SCORAD for AD patients. All patients with AD and 50% of controls were carriers of S. aureus, and harboured the bacteria simultaneously on skin and anterior nares. All of the S. aureus strains recovered from AD patient skin produced toxin and the B type was the most frequently detected (70%), followed by C (20%) and A (10%) toxins. Only 40% of the S. aureus isolates from control patients produced toxin. After UVB treatment, microbial population levels of AD patients were similar (P > 0.05) to the ones found in control patients before phototherapy, and toxin production ability of S. aureus isolates decreased drastically.

CONCLUSION

The results of the present study show the beneficial effect of UVB phototherapy on AD and suggest that this may be attributable not only to reduction of skin surface bacteria but also to the suppression of superantigen production from S. aureus.

Authors+Show Affiliations

Departamento de Microbiologia, ICB, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16987268

Citation

Silva, S H., et al. "Influence of Narrow-band UVB Phototherapy On Cutaneous Microbiota of Children With Atopic Dermatitis." Journal of the European Academy of Dermatology and Venereology : JEADV, vol. 20, no. 9, 2006, pp. 1114-20.
Silva SH, Guedes AC, Gontijo B, et al. Influence of narrow-band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis. J Eur Acad Dermatol Venereol. 2006;20(9):1114-20.
Silva, S. H., Guedes, A. C., Gontijo, B., Ramos, A. M., Carmo, L. S., Farias, L. M., & Nicoli, J. R. (2006). Influence of narrow-band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis. Journal of the European Academy of Dermatology and Venereology : JEADV, 20(9), 1114-20.
Silva SH, et al. Influence of Narrow-band UVB Phototherapy On Cutaneous Microbiota of Children With Atopic Dermatitis. J Eur Acad Dermatol Venereol. 2006;20(9):1114-20. PubMed PMID: 16987268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of narrow-band UVB phototherapy on cutaneous microbiota of children with atopic dermatitis. AU - Silva,S H, AU - Guedes,A C M, AU - Gontijo,B, AU - Ramos,A M C, AU - Carmo,L S, AU - Farias,L M, AU - Nicoli,J R, PY - 2006/9/22/pubmed PY - 2007/1/11/medline PY - 2006/9/22/entrez SP - 1114 EP - 20 JF - Journal of the European Academy of Dermatology and Venereology : JEADV JO - J Eur Acad Dermatol Venereol VL - 20 IS - 9 N2 - OBJECTIVE: In the present work, the effect of narrow-band ultraviolet B (UVB) phototherapy on a cutaneous microbial population was evaluated in patients with atopic dermatitis (AD) and compared with control patients (vitiligo). METHODS: Count, isolation and identification of cutaneous microbiota from anticubital fossa were performed in 10 controls and 10 AD patients, both submitted to similar levels (P > 0.05) of UVB phototherapy (4.3 +/- 0.9 and 4.3 +/- 0.8 accumulated joules, respectively). Additionally, Staphylococcus aureus isolates were screened for the production of exotoxins. RESULTS: The total and staphylococcal cutaneous microbial population levels were higher (P < 0.05) in AD patients than in the controls. All these population levels decreased (P < 0.05) for both AD and control patients after UVB phototherapy, which also decreased the SCORAD for AD patients. All patients with AD and 50% of controls were carriers of S. aureus, and harboured the bacteria simultaneously on skin and anterior nares. All of the S. aureus strains recovered from AD patient skin produced toxin and the B type was the most frequently detected (70%), followed by C (20%) and A (10%) toxins. Only 40% of the S. aureus isolates from control patients produced toxin. After UVB treatment, microbial population levels of AD patients were similar (P > 0.05) to the ones found in control patients before phototherapy, and toxin production ability of S. aureus isolates decreased drastically. CONCLUSION: The results of the present study show the beneficial effect of UVB phototherapy on AD and suggest that this may be attributable not only to reduction of skin surface bacteria but also to the suppression of superantigen production from S. aureus. SN - 0926-9959 UR - https://www.unboundmedicine.com/medline/citation/16987268/Influence_of_narrow_band_UVB_phototherapy_on_cutaneous_microbiota_of_children_with_atopic_dermatitis_ L2 - https://doi.org/10.1111/j.1468-3083.2006.01748.x DB - PRIME DP - Unbound Medicine ER -