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Very low-carbohydrate versus isocaloric high-carbohydrate diet in dietary obese rats.
Obesity (Silver Spring) 2006; 14(8):1344-52O

Abstract

OBJECTIVE

The effects of a very low-carbohydrate (VLC), high-fat (HF) dietary regimen on metabolic syndrome were compared with those of an isocaloric high-carbohydrate (HC), low-fat (LF) regimen in dietary obese rats.

RESEARCH METHODS AND PROCEDURES

Male Sprague-Dawley rats, made obese by 8 weeks ad libitum consumption of an HF diet, developed features of the metabolic syndrome vs. lean control (C) rats, including greater visceral, subcutaneous, and hepatic fat masses, elevated plasma cholesterol levels, impaired glucose tolerance, and fasting and post-load insulin resistance. Half of the obese rats (VLC) were then fed a popular VLC-HF diet (Weeks 9 and 10 at 5% and Weeks 11 to 14 at 15% carbohydrate), and one-half (HC) were pair-fed an HC-LF diet (Weeks 9 to 14 at 60% carbohydrate).

RESULTS

Energy intakes of pair-fed VLC and HC rats were less than C rats throughout Weeks 9 to 14. Compared with HC rats, VLC rats exhibited impaired insulin and glycemic responses to an intraperitoneal glucose load at Week 10 and lower plasma triacylglycerol levels but retarded loss of hepatic, retroperitoneal, and total body fat at Week 14. VLC, HC, and C rats no longer differed in body weight, plasma cholesterol, glucose tolerance, or fasting insulin resistance at Week 14. Progressive decreases in fasting insulin resistance in obese groups paralleled concomitant reductions in hepatic, retroperitoneal, and total body fat.

DISCUSSION

When energy intake was matched, the VLC-HF diet provided no advantage in weight loss or in improving those components of the metabolic syndrome induced by dietary obesity and may delay loss of hepatic and visceral fat as compared with an HC-LF diet.

Authors+Show Affiliations

Department of Health and Nutrition Sciences, Brooklyn College of City University of New York, 2900 Bedford Avenue, Brooklyn, NY 11210, USA. kaxen@brooklyn.cuny.eduNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16988076

Citation

Axen, Kathleen V., and Kenneth Axen. "Very Low-carbohydrate Versus Isocaloric High-carbohydrate Diet in Dietary Obese Rats." Obesity (Silver Spring, Md.), vol. 14, no. 8, 2006, pp. 1344-52.
Axen KV, Axen K. Very low-carbohydrate versus isocaloric high-carbohydrate diet in dietary obese rats. Obesity (Silver Spring). 2006;14(8):1344-52.
Axen, K. V., & Axen, K. (2006). Very low-carbohydrate versus isocaloric high-carbohydrate diet in dietary obese rats. Obesity (Silver Spring, Md.), 14(8), pp. 1344-52.
Axen KV, Axen K. Very Low-carbohydrate Versus Isocaloric High-carbohydrate Diet in Dietary Obese Rats. Obesity (Silver Spring). 2006;14(8):1344-52. PubMed PMID: 16988076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Very low-carbohydrate versus isocaloric high-carbohydrate diet in dietary obese rats. AU - Axen,Kathleen V, AU - Axen,Kenneth, PY - 2006/9/22/pubmed PY - 2006/10/31/medline PY - 2006/9/22/entrez SP - 1344 EP - 52 JF - Obesity (Silver Spring, Md.) JO - Obesity (Silver Spring) VL - 14 IS - 8 N2 - OBJECTIVE: The effects of a very low-carbohydrate (VLC), high-fat (HF) dietary regimen on metabolic syndrome were compared with those of an isocaloric high-carbohydrate (HC), low-fat (LF) regimen in dietary obese rats. RESEARCH METHODS AND PROCEDURES: Male Sprague-Dawley rats, made obese by 8 weeks ad libitum consumption of an HF diet, developed features of the metabolic syndrome vs. lean control (C) rats, including greater visceral, subcutaneous, and hepatic fat masses, elevated plasma cholesterol levels, impaired glucose tolerance, and fasting and post-load insulin resistance. Half of the obese rats (VLC) were then fed a popular VLC-HF diet (Weeks 9 and 10 at 5% and Weeks 11 to 14 at 15% carbohydrate), and one-half (HC) were pair-fed an HC-LF diet (Weeks 9 to 14 at 60% carbohydrate). RESULTS: Energy intakes of pair-fed VLC and HC rats were less than C rats throughout Weeks 9 to 14. Compared with HC rats, VLC rats exhibited impaired insulin and glycemic responses to an intraperitoneal glucose load at Week 10 and lower plasma triacylglycerol levels but retarded loss of hepatic, retroperitoneal, and total body fat at Week 14. VLC, HC, and C rats no longer differed in body weight, plasma cholesterol, glucose tolerance, or fasting insulin resistance at Week 14. Progressive decreases in fasting insulin resistance in obese groups paralleled concomitant reductions in hepatic, retroperitoneal, and total body fat. DISCUSSION: When energy intake was matched, the VLC-HF diet provided no advantage in weight loss or in improving those components of the metabolic syndrome induced by dietary obesity and may delay loss of hepatic and visceral fat as compared with an HC-LF diet. SN - 1930-7381 UR - https://www.unboundmedicine.com/medline/citation/16988076/Very_low_carbohydrate_versus_isocaloric_high_carbohydrate_diet_in_dietary_obese_rats_ L2 - https://doi.org/10.1038/oby.2006.152 DB - PRIME DP - Unbound Medicine ER -