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Antiproliferative triterpene saponins from Entada africana.
J Nat Prod. 2006 Sep; 69(9):1323-9.JN

Abstract

Nine new ester saponins (1-9) were isolated from the roots of Entada africana. Their structures were elucidated by 1D and 2D NMR experiments including 1D and 2D TOCSY, DQF-COSY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis, and chemical methods. The aglycon moieties were found to be echinocystic acid for compounds 1, 2, 4-6, 8, and 9 and acacic acid for 3 and 7. All isolated compounds were tested for their antiproliferative activity against the J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high cytotoxic potency was found for almost all compounds tested.

Authors+Show Affiliations

Cioffi G
Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084 Fisciano (SA), Italy.
Dal Piaz F
No affiliation info available
De Caprariis P
No affiliation info available
Sanogo R
No affiliation info available
Marzocco S
No affiliation info available
Autore G
No affiliation info available
De Tommasi N
No affiliation info available

MeSH

AnimalsAntineoplastic Agents, PhytogenicDrug Screening Assays, AntitumorFabaceaeHumansMacrophagesMaliMiceMolecular StructureNuclear Magnetic Resonance, BiomolecularPlant RootsPlants, MedicinalSaponinsTriterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16989528

Citation

Cioffi, Giuseppina, et al. "Antiproliferative Triterpene Saponins From Entada Africana." Journal of Natural Products, vol. 69, no. 9, 2006, pp. 1323-9.
Cioffi G, Dal Piaz F, De Caprariis P, et al. Antiproliferative triterpene saponins from Entada africana. J Nat Prod. 2006;69(9):1323-9.
Cioffi, G., Dal Piaz, F., De Caprariis, P., Sanogo, R., Marzocco, S., Autore, G., & De Tommasi, N. (2006). Antiproliferative triterpene saponins from Entada africana. Journal of Natural Products, 69(9), 1323-9.
Cioffi G, et al. Antiproliferative Triterpene Saponins From Entada Africana. J Nat Prod. 2006;69(9):1323-9. PubMed PMID: 16989528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antiproliferative triterpene saponins from Entada africana. AU - Cioffi,Giuseppina, AU - Dal Piaz,Fabrizio, AU - De Caprariis,Paolo, AU - Sanogo,Rokia, AU - Marzocco,Stefania, AU - Autore,Giuseppina, AU - De Tommasi,Nunziatina, PY - 2006/9/23/pubmed PY - 2006/10/31/medline PY - 2006/9/23/entrez SP - 1323 EP - 9 JF - Journal of natural products JO - J Nat Prod VL - 69 IS - 9 N2 - Nine new ester saponins (1-9) were isolated from the roots of Entada africana. Their structures were elucidated by 1D and 2D NMR experiments including 1D and 2D TOCSY, DQF-COSY, HSQC, and HMBC spectroscopy, as well as ESIMS analysis, and chemical methods. The aglycon moieties were found to be echinocystic acid for compounds 1, 2, 4-6, 8, and 9 and acacic acid for 3 and 7. All isolated compounds were tested for their antiproliferative activity against the J774.A1, HEK-293, and WEHI-164 cell lines. Moderate to high cytotoxic potency was found for almost all compounds tested. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/16989528/Antiproliferative_triterpene_saponins_from_Entada_africana_ L2 - https://doi.org/10.1021/np060257w DB - PRIME DP - Unbound Medicine ER -