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Effect of dietary sodium chloride on gastro-oesophageal reflux: a randomized controlled trial.
Scand J Gastroenterol 2006; 41(10):1141-6SJ

Abstract

OBJECTIVE

It has been suggested that a high consumption of sodium chloride (NaCl) is associated with reflux symptoms. The objective of this study was to investigate the effect of increased dietary NaCl intake on gastro-oesophageal reflux and reflux mechanisms.

MATERIAL AND METHODS

In this double-blind, placebo-controlled, crossover study 10 healthy male subjects received 5 g NaCl or placebo in capsules per day for one week, after which concurrent manometric, pH and impedance monitoring was carried out for 4.5 h.

RESULTS

Oesophageal acid exposure time (pH < 4) was similar for placebo (median 11% (25th 3-75th 36)) and NaCl (9% (1-36)). No differences in the numbers of reflux episodes were found for NaCl (16 (13.5-22)) and placebo (23 (14.8-27)). Furthermore, similar numbers of liquid acid reflux episodes (placebo 12 (6.5-17.3); NaCl 10 (2.3-14.3)), liquid weakly acidic reflux episodes (placebo 5.5 (4-12.3); NaCl 6.5 (3-10.8)) and gaseous reflux episodes (placebo 1 (0-1.8); NaCl 2 (0-3)) were seen. In both conditions transient lower oesophageal sphincter relaxations (TLOSRs) were the most common reflux mechanism, followed by swallow-induced reflux. High salt intake lowered LOS pressure overall and in the first postprandial hour (p<0.01).

CONCLUSIONS

High dietary sodium intake does not increase gastro-oesophageal reflux in healthy volunteers, despite a decrease in LOS pressure.

Authors+Show Affiliations

Gastrointestinal Research Unit, University Medical Center, Utrecht, The Netherlands. m.aanen@umcutrecht.nlNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16990198

Citation

Aanen, Marissa C., et al. "Effect of Dietary Sodium Chloride On Gastro-oesophageal Reflux: a Randomized Controlled Trial." Scandinavian Journal of Gastroenterology, vol. 41, no. 10, 2006, pp. 1141-6.
Aanen MC, Bredenoord AJ, Smout AJ. Effect of dietary sodium chloride on gastro-oesophageal reflux: a randomized controlled trial. Scand J Gastroenterol. 2006;41(10):1141-6.
Aanen, M. C., Bredenoord, A. J., & Smout, A. J. (2006). Effect of dietary sodium chloride on gastro-oesophageal reflux: a randomized controlled trial. Scandinavian Journal of Gastroenterology, 41(10), pp. 1141-6.
Aanen MC, Bredenoord AJ, Smout AJ. Effect of Dietary Sodium Chloride On Gastro-oesophageal Reflux: a Randomized Controlled Trial. Scand J Gastroenterol. 2006;41(10):1141-6. PubMed PMID: 16990198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of dietary sodium chloride on gastro-oesophageal reflux: a randomized controlled trial. AU - Aanen,Marissa C, AU - Bredenoord,Albert J, AU - Smout,André J P M, PY - 2006/9/23/pubmed PY - 2007/1/16/medline PY - 2006/9/23/entrez SP - 1141 EP - 6 JF - Scandinavian journal of gastroenterology JO - Scand. J. Gastroenterol. VL - 41 IS - 10 N2 - OBJECTIVE: It has been suggested that a high consumption of sodium chloride (NaCl) is associated with reflux symptoms. The objective of this study was to investigate the effect of increased dietary NaCl intake on gastro-oesophageal reflux and reflux mechanisms. MATERIAL AND METHODS: In this double-blind, placebo-controlled, crossover study 10 healthy male subjects received 5 g NaCl or placebo in capsules per day for one week, after which concurrent manometric, pH and impedance monitoring was carried out for 4.5 h. RESULTS: Oesophageal acid exposure time (pH < 4) was similar for placebo (median 11% (25th 3-75th 36)) and NaCl (9% (1-36)). No differences in the numbers of reflux episodes were found for NaCl (16 (13.5-22)) and placebo (23 (14.8-27)). Furthermore, similar numbers of liquid acid reflux episodes (placebo 12 (6.5-17.3); NaCl 10 (2.3-14.3)), liquid weakly acidic reflux episodes (placebo 5.5 (4-12.3); NaCl 6.5 (3-10.8)) and gaseous reflux episodes (placebo 1 (0-1.8); NaCl 2 (0-3)) were seen. In both conditions transient lower oesophageal sphincter relaxations (TLOSRs) were the most common reflux mechanism, followed by swallow-induced reflux. High salt intake lowered LOS pressure overall and in the first postprandial hour (p<0.01). CONCLUSIONS: High dietary sodium intake does not increase gastro-oesophageal reflux in healthy volunteers, despite a decrease in LOS pressure. SN - 0036-5521 UR - https://www.unboundmedicine.com/medline/citation/16990198/Effect_of_dietary_sodium_chloride_on_gastro_oesophageal_reflux:_a_randomized_controlled_trial_ L2 - http://www.tandfonline.com/doi/full/10.1080/00365520600615864 DB - PRIME DP - Unbound Medicine ER -