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Parental longevity, carotid atherosclerosis, and aortic arterial stiffness in adult offspring.
Stroke. 2006 Nov; 37(11):2702-7.S

Abstract

BACKGROUND AND PURPOSE

We examined the associations of parental longevity with carotid intima-media thickness, carotid plaques, and aortic arterial stiffness in adult offspring.

METHODS

A population of 1117 volunteers who participated in the SUVIMAX Vascular Study (mean age, 59.7 years; 49.0% women) were included. Carotid-femoral pulse-wave velocity (PWV) was used to assess aortic stiffness. Carotid B-mode ultrasound examination included measurements (at sites free of plaque) of intima-media thickness at the common carotid arteries and assessment of atherosclerotic plaques in the extracranial carotid arteries.

RESULTS

The prevalence of carotid plaques in subjects whose fathers had died at <65 years, in those whose fathers were alive at 65 years but who had died by 80 years, and in those whose fathers were alive at 80 years was 40.4%, 30.4%, and 28.9%, respectively (P<0.001). The multivariate odds ratios of carotid plaques in the 3 groups of paternal longevity, adjusted for conventional cardiovascular risk factors, were 1, 0.68 (95% CI, 0.48 to 0.96), and 0.69 (95% CI, 0.49 to 0.98), respectively. The mean common carotid arteries intima-media thickness was higher in subjects with premature paternal death in univariate (P<0.007) but not in multivariate (P=0.39) analyses. Mean PWV decreased with increasing paternal longevity in both univariate and multivariate analyses. The multivariate-adjusted means of PWV in the 3 groups of paternal longevity were 11.9+/-0.14, 11.7+/-0.12, and 11.0+/-0.12 m/s (P<0.0001), respectively. In contrast, neither B-mode ultrasound measurements nor PWV measurements were associated with maternal longevity.

CONCLUSIONS

These results may indicate that there are modifications of structure and function of large arteries according to paternal longevity.

Authors+Show Affiliations

National Institute of Health and Medical Research (INSERM), Unit 744, Lille, France. mahmoud.zureik@pasteur-lille.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

16990573

Citation

Zureik, Mahmoud, et al. "Parental Longevity, Carotid Atherosclerosis, and Aortic Arterial Stiffness in Adult Offspring." Stroke, vol. 37, no. 11, 2006, pp. 2702-7.
Zureik M, Czernichow S, Courbon D, et al. Parental longevity, carotid atherosclerosis, and aortic arterial stiffness in adult offspring. Stroke. 2006;37(11):2702-7.
Zureik, M., Czernichow, S., Courbon, D., Blacher, J., Ducimetière, P., Hercberg, S., Safar, M. E., & Galan, P. (2006). Parental longevity, carotid atherosclerosis, and aortic arterial stiffness in adult offspring. Stroke, 37(11), 2702-7.
Zureik M, et al. Parental Longevity, Carotid Atherosclerosis, and Aortic Arterial Stiffness in Adult Offspring. Stroke. 2006;37(11):2702-7. PubMed PMID: 16990573.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parental longevity, carotid atherosclerosis, and aortic arterial stiffness in adult offspring. AU - Zureik,Mahmoud, AU - Czernichow,Sébastien, AU - Courbon,Dominique, AU - Blacher,Jacques, AU - Ducimetière,Pierre, AU - Hercberg,Serge, AU - Safar,Michel E, AU - Galan,Pilar, Y1 - 2006/09/21/ PY - 2006/9/23/pubmed PY - 2006/11/15/medline PY - 2006/9/23/entrez SP - 2702 EP - 7 JF - Stroke JO - Stroke VL - 37 IS - 11 N2 - BACKGROUND AND PURPOSE: We examined the associations of parental longevity with carotid intima-media thickness, carotid plaques, and aortic arterial stiffness in adult offspring. METHODS: A population of 1117 volunteers who participated in the SUVIMAX Vascular Study (mean age, 59.7 years; 49.0% women) were included. Carotid-femoral pulse-wave velocity (PWV) was used to assess aortic stiffness. Carotid B-mode ultrasound examination included measurements (at sites free of plaque) of intima-media thickness at the common carotid arteries and assessment of atherosclerotic plaques in the extracranial carotid arteries. RESULTS: The prevalence of carotid plaques in subjects whose fathers had died at <65 years, in those whose fathers were alive at 65 years but who had died by 80 years, and in those whose fathers were alive at 80 years was 40.4%, 30.4%, and 28.9%, respectively (P<0.001). The multivariate odds ratios of carotid plaques in the 3 groups of paternal longevity, adjusted for conventional cardiovascular risk factors, were 1, 0.68 (95% CI, 0.48 to 0.96), and 0.69 (95% CI, 0.49 to 0.98), respectively. The mean common carotid arteries intima-media thickness was higher in subjects with premature paternal death in univariate (P<0.007) but not in multivariate (P=0.39) analyses. Mean PWV decreased with increasing paternal longevity in both univariate and multivariate analyses. The multivariate-adjusted means of PWV in the 3 groups of paternal longevity were 11.9+/-0.14, 11.7+/-0.12, and 11.0+/-0.12 m/s (P<0.0001), respectively. In contrast, neither B-mode ultrasound measurements nor PWV measurements were associated with maternal longevity. CONCLUSIONS: These results may indicate that there are modifications of structure and function of large arteries according to paternal longevity. SN - 1524-4628 UR - https://www.unboundmedicine.com/medline/citation/16990573/Parental_longevity_carotid_atherosclerosis_and_aortic_arterial_stiffness_in_adult_offspring_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.STR.0000244759.62619.83?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -