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Primitive neuroectodermal tumor of the uterus: a case report and review of literature.
Int J Gynecol Pathol. 2006 Oct; 25(4):373-7.IJ

Abstract

A case of primitive neuroectodermal tumor arising in the uterine corpus of a 43-year-old woman is presented. The tumor mass was 13.3 cm and extended to the uterine serosa, endocervical stroma, and left adnexa. Histologically, the tumor was composed of small blue cells with scant cytoplasm, indistinct cell borders, hyperchromatic round nuclei, and inconspicuous nucleoli focally forming pseudorosettes, suggestive of neuroectodermal origin. The tumor cells displayed strong immunoreactivity for CD99 and FLI1. Cytogenetic fluorescence in situ hybridization study revealed presence of an EWS-FLI1 fusion gene. To the best of our knowledge, this is the first case of primitive neuroectodermal tumor of the uterus with diagnosis confirmed by FLI1 immunohistochemical labeling and demonstration of t (11; 22) by fluorescence in situ hybridization.

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Authors+Show Affiliations

Varghese L
Department of Pathology, Allina Hospitals and Clinics Pathology Associates, Minneapolis, MN 55455, USA. varg0053@umn.edu
Arnesen M
No affiliation info available
Boente M
No affiliation info available

MeSH

12E7 AntigenAdultAntigens, CDCell Adhesion MoleculesCell NucleolusCell NucleusCytoplasmFemaleHumansImmunohistochemistryNeuroectodermal Tumors, PrimitiveOncogene Proteins, FusionProto-Oncogene Protein c-fli-1RNA-Binding Protein EWSUterine Neoplasms

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

16990715

Citation

Varghese, Linda, et al. "Primitive Neuroectodermal Tumor of the Uterus: a Case Report and Review of Literature." International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists, vol. 25, no. 4, 2006, pp. 373-7.
Varghese L, Arnesen M, Boente M. Primitive neuroectodermal tumor of the uterus: a case report and review of literature. Int J Gynecol Pathol. 2006;25(4):373-7.
Varghese, L., Arnesen, M., & Boente, M. (2006). Primitive neuroectodermal tumor of the uterus: a case report and review of literature. International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists, 25(4), 373-7.
Varghese L, Arnesen M, Boente M. Primitive Neuroectodermal Tumor of the Uterus: a Case Report and Review of Literature. Int J Gynecol Pathol. 2006;25(4):373-7. PubMed PMID: 16990715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primitive neuroectodermal tumor of the uterus: a case report and review of literature. AU - Varghese,Linda, AU - Arnesen,Mark, AU - Boente,Mathew, PY - 2006/9/23/pubmed PY - 2006/10/25/medline PY - 2006/9/23/entrez SP - 373 EP - 7 JF - International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists JO - Int J Gynecol Pathol VL - 25 IS - 4 N2 - A case of primitive neuroectodermal tumor arising in the uterine corpus of a 43-year-old woman is presented. The tumor mass was 13.3 cm and extended to the uterine serosa, endocervical stroma, and left adnexa. Histologically, the tumor was composed of small blue cells with scant cytoplasm, indistinct cell borders, hyperchromatic round nuclei, and inconspicuous nucleoli focally forming pseudorosettes, suggestive of neuroectodermal origin. The tumor cells displayed strong immunoreactivity for CD99 and FLI1. Cytogenetic fluorescence in situ hybridization study revealed presence of an EWS-FLI1 fusion gene. To the best of our knowledge, this is the first case of primitive neuroectodermal tumor of the uterus with diagnosis confirmed by FLI1 immunohistochemical labeling and demonstration of t (11; 22) by fluorescence in situ hybridization. SN - 0277-1691 UR - https://www.unboundmedicine.com/medline/citation/16990715/Primitive_neuroectodermal_tumor_of_the_uterus:_a_case_report_and_review_of_literature_ L2 - https://doi.org/10.1097/01.pgp.0000215300.39900.4e DB - PRIME DP - Unbound Medicine ER -