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Further evidence that anxiety and memory are regionally dissociated within the hippocampus.
Behav Brain Res. 2006 Nov 25; 175(1):183-8.BB

Abstract

The hippocampus has been implicated in the regulation of anxiety and memory processes. Nevertheless, the precise contribution of its ventral (VH) and dorsal (DH) division in these issues still remains a matter of debate. The Trial 1/2 protocol in the elevated plus-maze (EPM) is a suitable approach to assess features associated with anxiety and memory. Information about the spatial environment on initial (Trial 1) exploration leads to a subsequent increase in open-arm avoidance during retesting (Trial 2). The objective of the present study was to investigate whether transient VH or DH deactivation by lidocaine microinfusion would differently interfere with the performance of EPM-naive and EPM-experienced rats. Male Wistar rats were bilaterally-implanted with guide cannulas aimed at the VH or the DH. One-week after surgery, they received vehicle or lidocaine 2.0% in 1.0 microL (0.5 microL per side) at pre-Trial 1, post-Trial 1 or pre-Trial 2. There was an increase in open-arm exploration after the intra-VH lidocaine injection on Trial 1. Intra-DH pre-Trial 2 administration of lidocaine also reduced the open-arm avoidance. No significant changes were observed in enclosed-arm entries, an EPM index of general exploratory activity. The cautious exploration of potentially dangerous environment requires VH functional integrity, suggesting a specific role for this region in modulating anxiety-related behaviors. With regard to the DH, it may be preferentially involved in learning and memory since the acquired response of inhibitory avoidance was no longer observed when lidocaine was injected pre-Trial 2.

Authors+Show Affiliations

Department of Pharmacology, School of Medicine, University of São Paulo, Av. Bandeirantes, 3900 Ribeirão Preto, SP 14049-900, Brazil. ljbertoglio@ig.com.brNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16996146

Citation

Bertoglio, Leandro José, et al. "Further Evidence That Anxiety and Memory Are Regionally Dissociated Within the Hippocampus." Behavioural Brain Research, vol. 175, no. 1, 2006, pp. 183-8.
Bertoglio LJ, Joca SR, Guimarães FS. Further evidence that anxiety and memory are regionally dissociated within the hippocampus. Behav Brain Res. 2006;175(1):183-8.
Bertoglio, L. J., Joca, S. R., & Guimarães, F. S. (2006). Further evidence that anxiety and memory are regionally dissociated within the hippocampus. Behavioural Brain Research, 175(1), 183-8.
Bertoglio LJ, Joca SR, Guimarães FS. Further Evidence That Anxiety and Memory Are Regionally Dissociated Within the Hippocampus. Behav Brain Res. 2006 Nov 25;175(1):183-8. PubMed PMID: 16996146.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Further evidence that anxiety and memory are regionally dissociated within the hippocampus. AU - Bertoglio,Leandro José, AU - Joca,Sâmia Regiane Lourenço, AU - Guimarães,Francisco Silveira, Y1 - 2006/09/22/ PY - 2006/06/27/received PY - 2006/08/16/revised PY - 2006/08/18/accepted PY - 2006/9/26/pubmed PY - 2007/1/4/medline PY - 2006/9/26/entrez SP - 183 EP - 8 JF - Behavioural brain research JO - Behav Brain Res VL - 175 IS - 1 N2 - The hippocampus has been implicated in the regulation of anxiety and memory processes. Nevertheless, the precise contribution of its ventral (VH) and dorsal (DH) division in these issues still remains a matter of debate. The Trial 1/2 protocol in the elevated plus-maze (EPM) is a suitable approach to assess features associated with anxiety and memory. Information about the spatial environment on initial (Trial 1) exploration leads to a subsequent increase in open-arm avoidance during retesting (Trial 2). The objective of the present study was to investigate whether transient VH or DH deactivation by lidocaine microinfusion would differently interfere with the performance of EPM-naive and EPM-experienced rats. Male Wistar rats were bilaterally-implanted with guide cannulas aimed at the VH or the DH. One-week after surgery, they received vehicle or lidocaine 2.0% in 1.0 microL (0.5 microL per side) at pre-Trial 1, post-Trial 1 or pre-Trial 2. There was an increase in open-arm exploration after the intra-VH lidocaine injection on Trial 1. Intra-DH pre-Trial 2 administration of lidocaine also reduced the open-arm avoidance. No significant changes were observed in enclosed-arm entries, an EPM index of general exploratory activity. The cautious exploration of potentially dangerous environment requires VH functional integrity, suggesting a specific role for this region in modulating anxiety-related behaviors. With regard to the DH, it may be preferentially involved in learning and memory since the acquired response of inhibitory avoidance was no longer observed when lidocaine was injected pre-Trial 2. SN - 0166-4328 UR - https://www.unboundmedicine.com/medline/citation/16996146/Further_evidence_that_anxiety_and_memory_are_regionally_dissociated_within_the_hippocampus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(06)00479-7 DB - PRIME DP - Unbound Medicine ER -