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Clinical presentation of patients with eosinophilic inflammation of the esophagus.
Gastrointest Endosc 2006; 64(4):473-8GE

Abstract

BACKGROUND

Allergic eosinophilic esophagitis (AEE) is defined by a dense infiltrate of eosinophils within the esophageal mucosa and the absence of pathological gastroesophageal reflux.

OBJECTIVE

To characterize a pediatric population with AEE to determine if AEE can be diagnosed based on history; to compare patients with varying degrees of esophageal eosinophilic inflammation to determine if moderate esophageal inflammation is part of a continuum of AEE.

DESIGN

Medical records of 112 patients with eosinophils on esophageal biopsy specimens were reviewed. Patients were grouped according to eosinophils per high power field (eos/hpf): group 1 (1-5 eos/hpf, n = 31), group 2 (6-14 eos/hpf, n = 13), and group 3 (> or =15 eos/hpf, n = 68) and compared.

SETTING

University Children's Hospital.

PATIENTS

Children and adolescents with eosinophils on esophageal mucosal biopsy specimens.

INTERVENTIONS

Analysis of clinical information.

MAIN OUTCOME MEASUREMENTS

Clinical characterization of patients with esophageal eosinophilia.

RESULTS

There was no significant difference in patient demographics. Patients in groups 2 and 3 had multiple food allergens identified. Patients in group 3 with a positive type I allergic response were significantly younger than those with a negative response (mean, 4.6 years old vs mean, 8.5 years old; P = .0065). In group 2, 3 of 13 patients responded histologically to acid-suppressive therapy, whereas 6 patients had improved histology with corticosteroids; 4 of these 6 patients had not responded histologically to acid-suppression.

LIMITATIONS

Retrospective study.

CONCLUSIONS

History and clinical presentation were not useful in predicting the severity of histologic esophageal inflammation in this cohort. Patients with moderate esophageal eosinophilia (group 2) exhibited a variable response to medical therapy.

Authors+Show Affiliations

Department of Pediatrics, Indiana University School of Medicine, Indianapolis, Indiana, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16996334

Citation

Baxi, Sachin, et al. "Clinical Presentation of Patients With Eosinophilic Inflammation of the Esophagus." Gastrointestinal Endoscopy, vol. 64, no. 4, 2006, pp. 473-8.
Baxi S, Gupta SK, Swigonski N, et al. Clinical presentation of patients with eosinophilic inflammation of the esophagus. Gastrointest Endosc. 2006;64(4):473-8.
Baxi, S., Gupta, S. K., Swigonski, N., & Fitzgerald, J. F. (2006). Clinical presentation of patients with eosinophilic inflammation of the esophagus. Gastrointestinal Endoscopy, 64(4), pp. 473-8.
Baxi S, et al. Clinical Presentation of Patients With Eosinophilic Inflammation of the Esophagus. Gastrointest Endosc. 2006;64(4):473-8. PubMed PMID: 16996334.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical presentation of patients with eosinophilic inflammation of the esophagus. AU - Baxi,Sachin, AU - Gupta,Sandeep K, AU - Swigonski,Nancy, AU - Fitzgerald,Joseph F, Y1 - 2006/07/26/ PY - 2005/10/25/received PY - 2006/03/31/accepted PY - 2006/9/26/pubmed PY - 2007/2/3/medline PY - 2006/9/26/entrez SP - 473 EP - 8 JF - Gastrointestinal endoscopy JO - Gastrointest. Endosc. VL - 64 IS - 4 N2 - BACKGROUND: Allergic eosinophilic esophagitis (AEE) is defined by a dense infiltrate of eosinophils within the esophageal mucosa and the absence of pathological gastroesophageal reflux. OBJECTIVE: To characterize a pediatric population with AEE to determine if AEE can be diagnosed based on history; to compare patients with varying degrees of esophageal eosinophilic inflammation to determine if moderate esophageal inflammation is part of a continuum of AEE. DESIGN: Medical records of 112 patients with eosinophils on esophageal biopsy specimens were reviewed. Patients were grouped according to eosinophils per high power field (eos/hpf): group 1 (1-5 eos/hpf, n = 31), group 2 (6-14 eos/hpf, n = 13), and group 3 (> or =15 eos/hpf, n = 68) and compared. SETTING: University Children's Hospital. PATIENTS: Children and adolescents with eosinophils on esophageal mucosal biopsy specimens. INTERVENTIONS: Analysis of clinical information. MAIN OUTCOME MEASUREMENTS: Clinical characterization of patients with esophageal eosinophilia. RESULTS: There was no significant difference in patient demographics. Patients in groups 2 and 3 had multiple food allergens identified. Patients in group 3 with a positive type I allergic response were significantly younger than those with a negative response (mean, 4.6 years old vs mean, 8.5 years old; P = .0065). In group 2, 3 of 13 patients responded histologically to acid-suppressive therapy, whereas 6 patients had improved histology with corticosteroids; 4 of these 6 patients had not responded histologically to acid-suppression. LIMITATIONS: Retrospective study. CONCLUSIONS: History and clinical presentation were not useful in predicting the severity of histologic esophageal inflammation in this cohort. Patients with moderate esophageal eosinophilia (group 2) exhibited a variable response to medical therapy. SN - 0016-5107 UR - https://www.unboundmedicine.com/medline/citation/16996334/Clinical_presentation_of_patients_with_eosinophilic_inflammation_of_the_esophagus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5107(06)01811-6 DB - PRIME DP - Unbound Medicine ER -