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Relationship of progression of visual field damage to postural changes in intraocular pressure in patients with normal-tension glaucoma.
Ophthalmology 2006; 113(12):2150-5O

Abstract

PURPOSE

To evaluate whether postural changes of intraocular pressure (IOP) are associated with progression of visual field damage in patients with normal-tension glaucoma (NTG).

DESIGN

Prospective, noncomparative, nonrandomized study.

PARTICIPANTS

Sixty eyes of 33 patients with NTG.

METHODS

Intraocular pressure, blood pressure (BP), and pulse rate (PR) were measured in both sitting and supine positions. Visual fields were examined using Humphrey Field Analyzer (HFA; Zeiss-Humphrey Instruments, Inc., San Leandro, CA). Changes in mean deviation (MD) per year (dB/year), that is, MD slope, were calculated by linear regression analysis of the HFA Statpac 2 program.

MAIN OUTCOME MEASURES

The relationship between postural changes of IOP and MD slope was analyzed. The correlation between postural changes of IOP and cardiovascular parameters such as BP and PR also was analyzed.

RESULTS

The IOP in the supine position was significantly higher than that in the sitting position (P<0.001, paired t test). There was no significant correlation between MD slope and sitting IOP (Pearson r = 0.172; P = 0.188), but a significant correlation was found between MD slope and supine IOP (r = -0.261; P = 0.043). The MD slope significantly correlated with IOP elevation caused by the postural change (r = -0.682; P<0.001). The systolic BP in the supine position correlated with postural changes of IOP (r = 0.364; P = 0.004), but other cardiovascular parameters did not correlate with IOP parameters.

CONCLUSIONS

The progression of visual field damage in NTG is associated with IOP in the supine position and the magnitude of IOP elevation accompanying postural changes. These results suggest that deterioration in NTG may occur when patients are lying flat during sleep.

Authors+Show Affiliations

Department of Ophthalmology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan. kiuchi-t@md.tsukuba.ac.jpNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

16996611

Citation

Kiuchi, Takahiro, et al. "Relationship of Progression of Visual Field Damage to Postural Changes in Intraocular Pressure in Patients With Normal-tension Glaucoma." Ophthalmology, vol. 113, no. 12, 2006, pp. 2150-5.
Kiuchi T, Motoyama Y, Oshika T. Relationship of progression of visual field damage to postural changes in intraocular pressure in patients with normal-tension glaucoma. Ophthalmology. 2006;113(12):2150-5.
Kiuchi, T., Motoyama, Y., & Oshika, T. (2006). Relationship of progression of visual field damage to postural changes in intraocular pressure in patients with normal-tension glaucoma. Ophthalmology, 113(12), pp. 2150-5.
Kiuchi T, Motoyama Y, Oshika T. Relationship of Progression of Visual Field Damage to Postural Changes in Intraocular Pressure in Patients With Normal-tension Glaucoma. Ophthalmology. 2006;113(12):2150-5. PubMed PMID: 16996611.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of progression of visual field damage to postural changes in intraocular pressure in patients with normal-tension glaucoma. AU - Kiuchi,Takahiro, AU - Motoyama,Yuta, AU - Oshika,Tetsuro, Y1 - 2006/09/25/ PY - 2005/07/11/received PY - 2006/06/11/revised PY - 2006/06/19/accepted PY - 2006/9/26/pubmed PY - 2006/12/22/medline PY - 2006/9/26/entrez SP - 2150 EP - 5 JF - Ophthalmology JO - Ophthalmology VL - 113 IS - 12 N2 - PURPOSE: To evaluate whether postural changes of intraocular pressure (IOP) are associated with progression of visual field damage in patients with normal-tension glaucoma (NTG). DESIGN: Prospective, noncomparative, nonrandomized study. PARTICIPANTS: Sixty eyes of 33 patients with NTG. METHODS: Intraocular pressure, blood pressure (BP), and pulse rate (PR) were measured in both sitting and supine positions. Visual fields were examined using Humphrey Field Analyzer (HFA; Zeiss-Humphrey Instruments, Inc., San Leandro, CA). Changes in mean deviation (MD) per year (dB/year), that is, MD slope, were calculated by linear regression analysis of the HFA Statpac 2 program. MAIN OUTCOME MEASURES: The relationship between postural changes of IOP and MD slope was analyzed. The correlation between postural changes of IOP and cardiovascular parameters such as BP and PR also was analyzed. RESULTS: The IOP in the supine position was significantly higher than that in the sitting position (P<0.001, paired t test). There was no significant correlation between MD slope and sitting IOP (Pearson r = 0.172; P = 0.188), but a significant correlation was found between MD slope and supine IOP (r = -0.261; P = 0.043). The MD slope significantly correlated with IOP elevation caused by the postural change (r = -0.682; P<0.001). The systolic BP in the supine position correlated with postural changes of IOP (r = 0.364; P = 0.004), but other cardiovascular parameters did not correlate with IOP parameters. CONCLUSIONS: The progression of visual field damage in NTG is associated with IOP in the supine position and the magnitude of IOP elevation accompanying postural changes. These results suggest that deterioration in NTG may occur when patients are lying flat during sleep. SN - 1549-4713 UR - https://www.unboundmedicine.com/medline/citation/16996611/Relationship_of_progression_of_visual_field_damage_to_postural_changes_in_intraocular_pressure_in_patients_with_normal_tension_glaucoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0161-6420(06)00848-7 DB - PRIME DP - Unbound Medicine ER -