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Increased fMRI responses during encoding in mild cognitive impairment.
Neurobiol Aging. 2007 Dec; 28(12):1889-903.NA

Abstract

Structural and functional magnetic resonance imaging (fMRI) was performed on 21 healthy elderly controls, 14 subjects with mild cognitive impairment (MCI) and 15 patients with mild Alzheimer's disease (AD) to investigate changes in fMRI activation in relation to underlying structural atrophy. The fMRI paradigm consisted of associative encoding of novel picture-word pairs. Structural analysis of the brain was performed using voxel-based morphometry (VBM) and hippocampal volumetry. Compared to controls, the MCI subjects exhibited increased fMRI responses in the posterior hippocampal, parahippocampal and fusiform regions, while VBM revealed more atrophy in MCI in the anterior parts of the left hippocampus. Furthermore, the hippocampal volume and parahippocampal activation were negatively correlated in MCI, but not in controls or in AD. We suggest that the increased fMRI activation in MCI in the posterior medial temporal and closely connected fusiform regions is compensatory due to the incipient atrophy in the anterior medial temporal lobe.

Authors+Show Affiliations

Department of Neuroscience and Neurology, University of Kuopio, P.O. Box 1627, FIN-70211 Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16997428

Citation

Hämäläinen, Anne, et al. "Increased fMRI Responses During Encoding in Mild Cognitive Impairment." Neurobiology of Aging, vol. 28, no. 12, 2007, pp. 1889-903.
Hämäläinen A, Pihlajamäki M, Tanila H, et al. Increased fMRI responses during encoding in mild cognitive impairment. Neurobiol Aging. 2007;28(12):1889-903.
Hämäläinen, A., Pihlajamäki, M., Tanila, H., Hänninen, T., Niskanen, E., Tervo, S., Karjalainen, P. A., Vanninen, R. L., & Soininen, H. (2007). Increased fMRI responses during encoding in mild cognitive impairment. Neurobiology of Aging, 28(12), 1889-903.
Hämäläinen A, et al. Increased fMRI Responses During Encoding in Mild Cognitive Impairment. Neurobiol Aging. 2007;28(12):1889-903. PubMed PMID: 16997428.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased fMRI responses during encoding in mild cognitive impairment. AU - Hämäläinen,Anne, AU - Pihlajamäki,Maija, AU - Tanila,Heikki, AU - Hänninen,Tuomo, AU - Niskanen,Eini, AU - Tervo,Susanna, AU - Karjalainen,Pasi A, AU - Vanninen,Ritva L, AU - Soininen,Hilkka, Y1 - 2006/09/25/ PY - 2006/03/27/received PY - 2006/08/16/revised PY - 2006/08/21/accepted PY - 2006/9/26/pubmed PY - 2007/12/6/medline PY - 2006/9/26/entrez SP - 1889 EP - 903 JF - Neurobiology of aging JO - Neurobiol Aging VL - 28 IS - 12 N2 - Structural and functional magnetic resonance imaging (fMRI) was performed on 21 healthy elderly controls, 14 subjects with mild cognitive impairment (MCI) and 15 patients with mild Alzheimer's disease (AD) to investigate changes in fMRI activation in relation to underlying structural atrophy. The fMRI paradigm consisted of associative encoding of novel picture-word pairs. Structural analysis of the brain was performed using voxel-based morphometry (VBM) and hippocampal volumetry. Compared to controls, the MCI subjects exhibited increased fMRI responses in the posterior hippocampal, parahippocampal and fusiform regions, while VBM revealed more atrophy in MCI in the anterior parts of the left hippocampus. Furthermore, the hippocampal volume and parahippocampal activation were negatively correlated in MCI, but not in controls or in AD. We suggest that the increased fMRI activation in MCI in the posterior medial temporal and closely connected fusiform regions is compensatory due to the incipient atrophy in the anterior medial temporal lobe. SN - 1558-1497 UR - https://www.unboundmedicine.com/medline/citation/16997428/Increased_fMRI_responses_during_encoding_in_mild_cognitive_impairment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0197-4580(06)00303-4 DB - PRIME DP - Unbound Medicine ER -