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Ischemia-reperfusion alters the immunolocalization of glial aquaporins in rat retina.
Neurosci Lett. 2006 Nov 13; 408(2):108-12.NL

Abstract

Glial cells control the retinal osmohomeostasis, in part via mediation of water fluxes through aquaporin (AQP) water channels. By using immunohistochemical staining, we investigated whether ischemia-reperfusion of the rat retina causes alterations in the distribution of AQP1 and AQP4 proteins. Transient ischemia was induced in retinas of Long-Evans rats by elevation of the intraocular pressure for 60 min. In control retinas, immunoreactive AQP1 was expressed in the outer retina and by distinct amacrine cells, and AQP4 was expressed by glial cells (Müller cells and astrocytes) predominantly in the inner retina. After ischemia, retinal glial cells in the nerve fiber/ganglion cell layers strongly expressed AQP1. The perivascular staining around the superficial vessels altered from AQP4 in control retinas to AQP1 in postischemic retinas. The data suggest that the glial cell-mediated water transport in the retina is altered after ischemia especially at the superficial vessel plexus.

Authors+Show Affiliations

Paul Flechsig Institute of Brain Research, University of Leipzig Medical Faculty, 04109 Leipzig, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16997459

Citation

Iandiev, Ianors, et al. "Ischemia-reperfusion Alters the Immunolocalization of Glial Aquaporins in Rat Retina." Neuroscience Letters, vol. 408, no. 2, 2006, pp. 108-12.
Iandiev I, Pannicke T, Biedermann B, et al. Ischemia-reperfusion alters the immunolocalization of glial aquaporins in rat retina. Neurosci Lett. 2006;408(2):108-12.
Iandiev, I., Pannicke, T., Biedermann, B., Wiedemann, P., Reichenbach, A., & Bringmann, A. (2006). Ischemia-reperfusion alters the immunolocalization of glial aquaporins in rat retina. Neuroscience Letters, 408(2), 108-12.
Iandiev I, et al. Ischemia-reperfusion Alters the Immunolocalization of Glial Aquaporins in Rat Retina. Neurosci Lett. 2006 Nov 13;408(2):108-12. PubMed PMID: 16997459.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ischemia-reperfusion alters the immunolocalization of glial aquaporins in rat retina. AU - Iandiev,Ianors, AU - Pannicke,Thomas, AU - Biedermann,Bernd, AU - Wiedemann,Peter, AU - Reichenbach,Andreas, AU - Bringmann,Andreas, Y1 - 2006/09/25/ PY - 2006/06/29/received PY - 2006/08/16/revised PY - 2006/08/25/accepted PY - 2006/9/26/pubmed PY - 2007/4/7/medline PY - 2006/9/26/entrez SP - 108 EP - 12 JF - Neuroscience letters JO - Neurosci Lett VL - 408 IS - 2 N2 - Glial cells control the retinal osmohomeostasis, in part via mediation of water fluxes through aquaporin (AQP) water channels. By using immunohistochemical staining, we investigated whether ischemia-reperfusion of the rat retina causes alterations in the distribution of AQP1 and AQP4 proteins. Transient ischemia was induced in retinas of Long-Evans rats by elevation of the intraocular pressure for 60 min. In control retinas, immunoreactive AQP1 was expressed in the outer retina and by distinct amacrine cells, and AQP4 was expressed by glial cells (Müller cells and astrocytes) predominantly in the inner retina. After ischemia, retinal glial cells in the nerve fiber/ganglion cell layers strongly expressed AQP1. The perivascular staining around the superficial vessels altered from AQP4 in control retinas to AQP1 in postischemic retinas. The data suggest that the glial cell-mediated water transport in the retina is altered after ischemia especially at the superficial vessel plexus. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16997459/Ischemia_reperfusion_alters_the_immunolocalization_of_glial_aquaporins_in_rat_retina_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(06)00885-8 DB - PRIME DP - Unbound Medicine ER -