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Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer's disease.
Neurosci Lett. 2006 Nov 06; 408(1):68-72.NL

Abstract

We have recently demonstrated that apolipoprotein E (APOE)-varepsilon4 allele is a risk factor for Alzheimer disease (AD) in Tehran, Iran. The current study specifically aimed to examine whether APOE polymorphism in association with serum lipids-apolipoprotein level is a risk factor for AD in a population from Tehran, Iran. APOE polymorphism and plasma lipids, apoA1, apoB and lipoprotein (a) (Lp(a)) levels were determined in 94 AD patients and 111matched controls. Our study demonstrated a significant association between APOE polymorphism and the level of plasma lipids and apolipoprotein with AD in this population. The AD subjects had significantly lower apoA1 (p<0.001) and HDL-C (p<0.01) and higher apoB (p=0.01) and LDL-C (p=0.02) levels than that of the control group. The AD subjects carrying APOE-varepsilon4 allele had lower plasma apoA1 (t=5.2, p<0.002) and HDL-C level (t=2.7, p=0.01) but had higher plasma apoB (t=-5.4, p<0.002), LDL-C (t=-4.6, p=0.005) and total cholesterol (TC) (t=-2.7, p=0.01) than that of the non APOE-varepsilon4 carriers. These results indicated that AD patients with APOE-varepsilon4 allele has a distinct plasma lipid profile and carrier of this allele with low levels of apoA1 and HDL-C may be more susceptible to AD.

Authors+Show Affiliations

Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Daneshgah Avenue, P.O. Box 67148, 69914 Kermanshah, Iran. vaisira@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16997467

Citation

Raygani, Asad Vaisi, et al. "Association Between Apolipoprotein E Polymorphism and Serum Lipid and Apolipoprotein Levels With Alzheimer's Disease." Neuroscience Letters, vol. 408, no. 1, 2006, pp. 68-72.
Raygani AV, Rahimi Z, Kharazi H, et al. Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer's disease. Neurosci Lett. 2006;408(1):68-72.
Raygani, A. V., Rahimi, Z., Kharazi, H., Tavilani, H., & Pourmotabbed, T. (2006). Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer's disease. Neuroscience Letters, 408(1), 68-72.
Raygani AV, et al. Association Between Apolipoprotein E Polymorphism and Serum Lipid and Apolipoprotein Levels With Alzheimer's Disease. Neurosci Lett. 2006 Nov 6;408(1):68-72. PubMed PMID: 16997467.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between apolipoprotein E polymorphism and serum lipid and apolipoprotein levels with Alzheimer's disease. AU - Raygani,Asad Vaisi, AU - Rahimi,Zohreh, AU - Kharazi,Hadi, AU - Tavilani,Haidar, AU - Pourmotabbed,Tayebeh, Y1 - 2006/09/25/ PY - 2006/05/18/received PY - 2006/08/16/revised PY - 2006/08/19/accepted PY - 2006/9/26/pubmed PY - 2007/4/4/medline PY - 2006/9/26/entrez SP - 68 EP - 72 JF - Neuroscience letters JO - Neurosci Lett VL - 408 IS - 1 N2 - We have recently demonstrated that apolipoprotein E (APOE)-varepsilon4 allele is a risk factor for Alzheimer disease (AD) in Tehran, Iran. The current study specifically aimed to examine whether APOE polymorphism in association with serum lipids-apolipoprotein level is a risk factor for AD in a population from Tehran, Iran. APOE polymorphism and plasma lipids, apoA1, apoB and lipoprotein (a) (Lp(a)) levels were determined in 94 AD patients and 111matched controls. Our study demonstrated a significant association between APOE polymorphism and the level of plasma lipids and apolipoprotein with AD in this population. The AD subjects had significantly lower apoA1 (p<0.001) and HDL-C (p<0.01) and higher apoB (p=0.01) and LDL-C (p=0.02) levels than that of the control group. The AD subjects carrying APOE-varepsilon4 allele had lower plasma apoA1 (t=5.2, p<0.002) and HDL-C level (t=2.7, p=0.01) but had higher plasma apoB (t=-5.4, p<0.002), LDL-C (t=-4.6, p=0.005) and total cholesterol (TC) (t=-2.7, p=0.01) than that of the non APOE-varepsilon4 carriers. These results indicated that AD patients with APOE-varepsilon4 allele has a distinct plasma lipid profile and carrier of this allele with low levels of apoA1 and HDL-C may be more susceptible to AD. SN - 0304-3940 UR - https://www.unboundmedicine.com/medline/citation/16997467/Association_between_apolipoprotein_E_polymorphism_and_serum_lipid_and_apolipoprotein_levels_with_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-3940(06)00871-8 DB - PRIME DP - Unbound Medicine ER -