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[A prospective study comparing the efficacy of early administration of terlipressin and somatostatin for the control of acute variceal bleeding in patients with cirrhosis].
Korean J Hepatol 2006; 12(3):373-84KJ

Abstract

BACKGROUND/AIMS

Terlipressin and somatostatin decrease portal venous pressure and they are used for the treatment of variceal bleeding. However, only a few studies have compared the efficacy of these drugs in combination with other procedures for hemostasis. Therefore, we performed a prospective study to compare the efficacy of terlipressin and somatostatin for controlling acute variceal bleeding when used in combination with other procedures for hemostasis.

METHODS

A total of 98 patients, who presented with variceal bleeding from September 2003 to May 2005, were randomly divided into the somatostatin group or terlipressin group. We compared the 5-day failure rate (defined as failure to control bleeding, rebleeding or death within 5 days of admission) and the 6-week mortality. The prognostic factors for 5-day failure and 6-week mortality were also evaluated.

RESULTS

There were no differences in baseline characteristics between the two groups. The overall 5-day failure rate and the cumulative 6-week mortality were 16.3% and 15.8%, respectively. The five-day failure rate and the cumulative 6-week mortality were not significantly different between the somatostatin and terlipressin groups. Hepatocellular carcinoma, the baseline serum creatinine level and endoscopic treatment for hemostasis were the significant predictors of 5-day failure; the baseline serum creatinine level was the predictor of 6-week mortality.

CONCLUSIONS

Both somatostatin and terlipressin were effective and showed comparable efficacy for the control of the acute variceal bleeding in the setting of a combined therapeutic approach. The baseline serum creatinine level may be a significant predictor for patient failure at 5 days and the 6-week mortality.

Authors+Show Affiliations

Department of Internal Medicine, College of Medicine, Korea University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

kor

PubMed ID

16998289

Citation

Seo, Yeon Seok, et al. "[A Prospective Study Comparing the Efficacy of Early Administration of Terlipressin and Somatostatin for the Control of Acute Variceal Bleeding in Patients With Cirrhosis]." The Korean Journal of Hepatology, vol. 12, no. 3, 2006, pp. 373-84.
Seo YS, Um SH, Hyun JJ, et al. [A prospective study comparing the efficacy of early administration of terlipressin and somatostatin for the control of acute variceal bleeding in patients with cirrhosis]. Korean J Hepatol. 2006;12(3):373-84.
Seo, Y. S., Um, S. H., Hyun, J. J., Kim, Y. H., Park, S., Keum, B. R., ... Ryu, H. S. (2006). [A prospective study comparing the efficacy of early administration of terlipressin and somatostatin for the control of acute variceal bleeding in patients with cirrhosis]. The Korean Journal of Hepatology, 12(3), pp. 373-84.
Seo YS, et al. [A Prospective Study Comparing the Efficacy of Early Administration of Terlipressin and Somatostatin for the Control of Acute Variceal Bleeding in Patients With Cirrhosis]. Korean J Hepatol. 2006;12(3):373-84. PubMed PMID: 16998289.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [A prospective study comparing the efficacy of early administration of terlipressin and somatostatin for the control of acute variceal bleeding in patients with cirrhosis]. AU - Seo,Yeon Seok, AU - Um,Soon Ho, AU - Hyun,Jong Jin, AU - Kim,Youn Ho, AU - Park,Sanghoon, AU - Keum,Bo Ra, AU - Kim,Yong Sik, AU - Jeen,Yoon Tae, AU - Lee,Hong Sik, AU - Chun,Hoon Jai, AU - Lee,Sang Woo, AU - Choi,Jai Hyun, AU - Kim,Chang Duck, AU - Ryu,Ho Sang, PY - 2006/9/26/pubmed PY - 2008/7/31/medline PY - 2006/9/26/entrez SP - 373 EP - 84 JF - The Korean journal of hepatology JO - Korean J Hepatol VL - 12 IS - 3 N2 - BACKGROUND/AIMS: Terlipressin and somatostatin decrease portal venous pressure and they are used for the treatment of variceal bleeding. However, only a few studies have compared the efficacy of these drugs in combination with other procedures for hemostasis. Therefore, we performed a prospective study to compare the efficacy of terlipressin and somatostatin for controlling acute variceal bleeding when used in combination with other procedures for hemostasis. METHODS: A total of 98 patients, who presented with variceal bleeding from September 2003 to May 2005, were randomly divided into the somatostatin group or terlipressin group. We compared the 5-day failure rate (defined as failure to control bleeding, rebleeding or death within 5 days of admission) and the 6-week mortality. The prognostic factors for 5-day failure and 6-week mortality were also evaluated. RESULTS: There were no differences in baseline characteristics between the two groups. The overall 5-day failure rate and the cumulative 6-week mortality were 16.3% and 15.8%, respectively. The five-day failure rate and the cumulative 6-week mortality were not significantly different between the somatostatin and terlipressin groups. Hepatocellular carcinoma, the baseline serum creatinine level and endoscopic treatment for hemostasis were the significant predictors of 5-day failure; the baseline serum creatinine level was the predictor of 6-week mortality. CONCLUSIONS: Both somatostatin and terlipressin were effective and showed comparable efficacy for the control of the acute variceal bleeding in the setting of a combined therapeutic approach. The baseline serum creatinine level may be a significant predictor for patient failure at 5 days and the 6-week mortality. SN - 1738-222X UR - https://www.unboundmedicine.com/medline/citation/16998289/[A_prospective_study_comparing_the_efficacy_of_early_administration_of_terlipressin_and_somatostatin_for_the_control_of_acute_variceal_bleeding_in_patients_with_cirrhosis]_ L2 - https://medlineplus.gov/cirrhosis.html DB - PRIME DP - Unbound Medicine ER -