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[Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding].
Korean J Hepatol. 2006 Sep; 12(3):394-403.KJ

Abstract

BACKGROUND/AIMS

Gastric variceal bleeding is a severe complication of cirrhosis, and it has a high mortality rate. This study was conducted to evaluate the efficacy of n-butyl-2-cyanoacrylate injection therapy for patients suffering with gastric variceal bleeding.

METHODS

A total of 86 patients diagnosed with gastric variceal bleeding underwent endoscopic n-butyl-2-cyanoacrylate (Histoacryl) injection therapy at our department between April, 2002 and July, 2005, with a mean follow-up period of 44 weeks (range: 2 to 136 weeks). The initial hemostasis rate and the rebleeding rate of endoscopic sclerotherapy were analyzed. Also, the cumulative survival rate was analyzed according to the status of hepatocellular carcinoma and hyponatremia, the MELD score, the Child-Pugh score and the amount of injected Histoacryl.

RESULTS

The initial hemostasis rate of Histoacryl injection therapy was 93% and the 1 month rebleeding rate was 16.1%. The total number of session for treating the initial hemostasis was 1.2+/-0.4 and the total volume of Histoacryl was 2.7+/-1.2 mL. The cumulative rebleeding-free rates for the patients treated by the Histoacryl injection method at 1 month, 12 months and 34 months period were 95.1%, 83.2% and 74%, respectively. The cumulative survival rates were 78.3% at 1 month, 61.9% at 12 months and 54.6% at 34 months, respectively. No thromboembolic phenomenon occurred. According to the Cox's proportional hazards analysis, only the MELD score (<15) was an independent predicting factor for survival of the patients with gastric variceal bleeding.

CONCLUSIONS

Endoscopic sclerotherapy using n-butyl-2-cyanoacrylate was a safe and effective hemostatic method for patients with gastric variceal bleeding. Also, the MELD score (<15) contributed to predicting survival of the patients with gastric variceal bleeding.

Authors+Show Affiliations

Department of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Republic of Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
English Abstract
Journal Article

Language

kor

PubMed ID

16998291

Citation

Kim, Jae Woo, et al. "[Effect of Endoscopic Sclerotherapy Using N-butyl-2-cyanoacrylate in Patients With Gastric Variceal Bleeding]." The Korean Journal of Hepatology, vol. 12, no. 3, 2006, pp. 394-403.
Kim JW, Baik SK, Kim KH, et al. [Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding]. Korean J Hepatol. 2006;12(3):394-403.
Kim, J. W., Baik, S. K., Kim, K. H., Kim, H. J., Jo, K. W., Hong, J. H., Jee, M. G., Kim, H. S., & Kwon, S. O. (2006). [Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding]. The Korean Journal of Hepatology, 12(3), 394-403.
Kim JW, et al. [Effect of Endoscopic Sclerotherapy Using N-butyl-2-cyanoacrylate in Patients With Gastric Variceal Bleeding]. Korean J Hepatol. 2006;12(3):394-403. PubMed PMID: 16998291.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Effect of endoscopic sclerotherapy using N-butyl-2-cyanoacrylate in patients with gastric variceal bleeding]. AU - Kim,Jae Woo, AU - Baik,Soon Koo, AU - Kim,Kyu Hong, AU - Kim,Hye Jeong, AU - Jo,Ki Won, AU - Hong,Jin Hon, AU - Jee,Myeong Gwan, AU - Kim,Hyun Soo, AU - Kwon,Sang Ok, PY - 2006/9/26/pubmed PY - 2008/7/31/medline PY - 2006/9/26/entrez SP - 394 EP - 403 JF - The Korean journal of hepatology JO - Korean J Hepatol VL - 12 IS - 3 N2 - BACKGROUND/AIMS: Gastric variceal bleeding is a severe complication of cirrhosis, and it has a high mortality rate. This study was conducted to evaluate the efficacy of n-butyl-2-cyanoacrylate injection therapy for patients suffering with gastric variceal bleeding. METHODS: A total of 86 patients diagnosed with gastric variceal bleeding underwent endoscopic n-butyl-2-cyanoacrylate (Histoacryl) injection therapy at our department between April, 2002 and July, 2005, with a mean follow-up period of 44 weeks (range: 2 to 136 weeks). The initial hemostasis rate and the rebleeding rate of endoscopic sclerotherapy were analyzed. Also, the cumulative survival rate was analyzed according to the status of hepatocellular carcinoma and hyponatremia, the MELD score, the Child-Pugh score and the amount of injected Histoacryl. RESULTS: The initial hemostasis rate of Histoacryl injection therapy was 93% and the 1 month rebleeding rate was 16.1%. The total number of session for treating the initial hemostasis was 1.2+/-0.4 and the total volume of Histoacryl was 2.7+/-1.2 mL. The cumulative rebleeding-free rates for the patients treated by the Histoacryl injection method at 1 month, 12 months and 34 months period were 95.1%, 83.2% and 74%, respectively. The cumulative survival rates were 78.3% at 1 month, 61.9% at 12 months and 54.6% at 34 months, respectively. No thromboembolic phenomenon occurred. According to the Cox's proportional hazards analysis, only the MELD score (<15) was an independent predicting factor for survival of the patients with gastric variceal bleeding. CONCLUSIONS: Endoscopic sclerotherapy using n-butyl-2-cyanoacrylate was a safe and effective hemostatic method for patients with gastric variceal bleeding. Also, the MELD score (<15) contributed to predicting survival of the patients with gastric variceal bleeding. SN - 1738-222X UR - https://www.unboundmedicine.com/medline/citation/16998291/[Effect_of_endoscopic_sclerotherapy_using_N_butyl_2_cyanoacrylate_in_patients_with_gastric_variceal_bleeding]_ L2 - https://medlineplus.gov/gastrointestinalbleeding.html DB - PRIME DP - Unbound Medicine ER -