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Biochemical effects of Nigella sativa L seeds in diabetic rats.
Indian J Exp Biol. 2006 Sep; 44(9):745-8.IJ

Abstract

Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxidant enzymes like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase in liver and kidney. The results confirm the antidiabetic activity of N. sativa seeds extract and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic rats.

Authors+Show Affiliations

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

16999030

Citation

Kaleem, M, et al. "Biochemical Effects of Nigella Sativa L Seeds in Diabetic Rats." Indian Journal of Experimental Biology, vol. 44, no. 9, 2006, pp. 745-8.
Kaleem M, Kirmani D, Asif M, et al. Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian J Exp Biol. 2006;44(9):745-8.
Kaleem, M., Kirmani, D., Asif, M., Ahmed, Q., & Bano, B. (2006). Biochemical effects of Nigella sativa L seeds in diabetic rats. Indian Journal of Experimental Biology, 44(9), 745-8.
Kaleem M, et al. Biochemical Effects of Nigella Sativa L Seeds in Diabetic Rats. Indian J Exp Biol. 2006;44(9):745-8. PubMed PMID: 16999030.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biochemical effects of Nigella sativa L seeds in diabetic rats. AU - Kaleem,M, AU - Kirmani,D, AU - Asif,M, AU - Ahmed,Q, AU - Bano,Bilqees, PY - 2006/9/27/pubmed PY - 2006/11/7/medline PY - 2006/9/27/entrez SP - 745 EP - 8 JF - Indian journal of experimental biology JO - Indian J Exp Biol VL - 44 IS - 9 N2 - Oral administration of ethanol extract of N. sativa seeds (300 mg/kg body weight/day) to streptozotocin induced diabetic rats for 30 days significantly reduced the elevated levels of blood glucose, lipids, plasma insulin and improved altered levels of lipid peroxidation products (TBARS and hydroperoxides) and antioxidant enzymes like catalase, superoxide dismutase, reduced glutathione and glutathione peroxidase in liver and kidney. The results confirm the antidiabetic activity of N. sativa seeds extract and suggest that because of its antioxidant effects its administration may be useful in controlling the diabetic complications in experimental diabetic rats. SN - 0019-5189 UR - https://www.unboundmedicine.com/medline/citation/16999030/Biochemical_effects_of_Nigella_sativa_L_seeds_in_diabetic_rats_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -