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Endocrine and immunohistochemical studies on thyrotropin (TSH)-secreting pituitary adenomas: responses of TSH, alpha-subunit, and growth hormone to hypothalamic releasing hormones and their distribution in adenoma cells.
J Clin Endocrinol Metab. 1990 Nov; 71(5):1103-11.JC

Abstract

Endocrine and immunohistochemical studies were performed in two cases of TSH-secreting pituitary adenomas. The patients had elevated serum TSH and alpha-subunit concentrations despite high serum thyroid hormone levels. In addition, one patient (no. 1) had elevated serum GH levels with clinical evidence of acromegaly. GH-releasing hormone infusion increased serum levels of TSH, alpha-subunit and GH in the two patients. TRH injection increased serum TSH levels in both patients and, concomitantly, serum alpha-subunit and GH levels in patient 1. Basal TSH levels and their responses to TRH changed reciprocally to changes in serum thyroid hormone levels, although TRH-induced GH release did not. The administration of GnRH also increased serum TSH, alpha-subunit, and GH levels in patient 1. In accordance with these in vivo results, pituitary adenoma cells in culture obtained from patient 1 responded to GH-releasing hormone, TRH, or GnRH to secrete TSH, alpha-subunit, and GH. Incubation of cells with dexamethasone resulted in inhibition of TSH and stimulation of GH secretion without a significant change in alpha-subunit secretion. On the basis of light microscopic and electron microscopic double gold immunohistochemistry, the tumor from patient 1 was a bimorphous adenoma composed of two separate cell types: cells with TSH beta-subunit (TSH beta) and alpha-subunit, and those with GH and alpha-subunit. The remainder consisted mainly of cells with TSH beta and alpha-subunit. The coproduction of the unusual combination of two hormones such as GH and alpha-subunit in a single-type of adenoma cell and the coexistence of thyrotrophs and somatotrophs in one pituitary adenoma along with the aberrant responses of TSH beta, alpha-subunit, and GH to multiple hypothalamic hormones suggest the dedifferentiation of pituitary cells to multipotential progenitor cells by neoplastic transformation.

Authors+Show Affiliations

Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

1699960

Citation

Kuzuya, N, et al. "Endocrine and Immunohistochemical Studies On Thyrotropin (TSH)-secreting Pituitary Adenomas: Responses of TSH, Alpha-subunit, and Growth Hormone to Hypothalamic Releasing Hormones and Their Distribution in Adenoma Cells." The Journal of Clinical Endocrinology and Metabolism, vol. 71, no. 5, 1990, pp. 1103-11.
Kuzuya N, Inoue K, Ishibashi M, et al. Endocrine and immunohistochemical studies on thyrotropin (TSH)-secreting pituitary adenomas: responses of TSH, alpha-subunit, and growth hormone to hypothalamic releasing hormones and their distribution in adenoma cells. J Clin Endocrinol Metab. 1990;71(5):1103-11.
Kuzuya, N., Inoue, K., Ishibashi, M., Murayama, Y., Koide, Y., Ito, K., Yamaji, T., & Yamashita, K. (1990). Endocrine and immunohistochemical studies on thyrotropin (TSH)-secreting pituitary adenomas: responses of TSH, alpha-subunit, and growth hormone to hypothalamic releasing hormones and their distribution in adenoma cells. The Journal of Clinical Endocrinology and Metabolism, 71(5), 1103-11.
Kuzuya N, et al. Endocrine and Immunohistochemical Studies On Thyrotropin (TSH)-secreting Pituitary Adenomas: Responses of TSH, Alpha-subunit, and Growth Hormone to Hypothalamic Releasing Hormones and Their Distribution in Adenoma Cells. J Clin Endocrinol Metab. 1990;71(5):1103-11. PubMed PMID: 1699960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endocrine and immunohistochemical studies on thyrotropin (TSH)-secreting pituitary adenomas: responses of TSH, alpha-subunit, and growth hormone to hypothalamic releasing hormones and their distribution in adenoma cells. AU - Kuzuya,N, AU - Inoue,K, AU - Ishibashi,M, AU - Murayama,Y, AU - Koide,Y, AU - Ito,K, AU - Yamaji,T, AU - Yamashita,K, PY - 1990/11/1/pubmed PY - 1990/11/1/medline PY - 1990/11/1/entrez SP - 1103 EP - 11 JF - The Journal of clinical endocrinology and metabolism JO - J Clin Endocrinol Metab VL - 71 IS - 5 N2 - Endocrine and immunohistochemical studies were performed in two cases of TSH-secreting pituitary adenomas. The patients had elevated serum TSH and alpha-subunit concentrations despite high serum thyroid hormone levels. In addition, one patient (no. 1) had elevated serum GH levels with clinical evidence of acromegaly. GH-releasing hormone infusion increased serum levels of TSH, alpha-subunit and GH in the two patients. TRH injection increased serum TSH levels in both patients and, concomitantly, serum alpha-subunit and GH levels in patient 1. Basal TSH levels and their responses to TRH changed reciprocally to changes in serum thyroid hormone levels, although TRH-induced GH release did not. The administration of GnRH also increased serum TSH, alpha-subunit, and GH levels in patient 1. In accordance with these in vivo results, pituitary adenoma cells in culture obtained from patient 1 responded to GH-releasing hormone, TRH, or GnRH to secrete TSH, alpha-subunit, and GH. Incubation of cells with dexamethasone resulted in inhibition of TSH and stimulation of GH secretion without a significant change in alpha-subunit secretion. On the basis of light microscopic and electron microscopic double gold immunohistochemistry, the tumor from patient 1 was a bimorphous adenoma composed of two separate cell types: cells with TSH beta-subunit (TSH beta) and alpha-subunit, and those with GH and alpha-subunit. The remainder consisted mainly of cells with TSH beta and alpha-subunit. The coproduction of the unusual combination of two hormones such as GH and alpha-subunit in a single-type of adenoma cell and the coexistence of thyrotrophs and somatotrophs in one pituitary adenoma along with the aberrant responses of TSH beta, alpha-subunit, and GH to multiple hypothalamic hormones suggest the dedifferentiation of pituitary cells to multipotential progenitor cells by neoplastic transformation. SN - 0021-972X UR - https://www.unboundmedicine.com/medline/citation/1699960/Endocrine_and_immunohistochemical_studies_on_thyrotropin__TSH__secreting_pituitary_adenomas:_responses_of_TSH_alpha_subunit_and_growth_hormone_to_hypothalamic_releasing_hormones_and_their_distribution_in_adenoma_cells_ L2 - https://academic.oup.com/jcem/article-lookup/doi/10.1210/jcem-71-5-1103 DB - PRIME DP - Unbound Medicine ER -