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Lead neurotoxicity in children: is prenatal exposure more important than postnatal exposure?
Acta Paediatr Suppl. 2006 Oct; 95(453):45-9.AP

Abstract

Numerous studies indicate that low-level lead poisoning causes mild mental retardation and low IQ scores in children. The general mean lead intake in the adult European population corresponds to a reassuring 14% (0.5-56%) of the tolerable daily intake: at this low level of exposure only few children (less than 10%) have blood lead levels (PbB) higher than 10 microg/dl, previously considered the PbB of concern. In more recent years data now suggest that even when 'the lifetime average blood lead concentration' is below 10 microg/dl an inverse association exists with intelligence quotient (IQ) scores. Two-thirds (45-75%) of lead in blood, however, comes from long-term tissue stores and this is especially true for newborn infants and pregnant women. Several data suggest that for lead the main toxic event is prenatal exposure: therefore we should focus our attention on maternal lead stores and whenever possible avoid their mobilization during pregnancy. In this regard we should design appropriate studies to confirm whether dietary supplementations can reduce bone resorption and lead mobilization during pregnancy. The hypothesis that the amount of maternal bone lead stores is the relevant parameter for predicting the level of neurotoxicity of this metal gives some optimism for the future: if we study children whose mothers never underwent high environmental pollution (born after the withdrawal of lead from gasoline) and hence have relatively low bone lead stores we could find that, at the population level, lead has little influence on children IQ scores.

Authors+Show Affiliations

Department of Paediatrics, Second School of Medicine, University 'La Sapienza', Rome, Italy. roberto.ronchetti@ospedalesantandrea.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17000569

Citation

Ronchetti, Roberto, et al. "Lead Neurotoxicity in Children: Is Prenatal Exposure More Important Than Postnatal Exposure?" Acta Paediatrica (Oslo, Norway : 1992). Supplement, vol. 95, no. 453, 2006, pp. 45-9.
Ronchetti R, van den Hazel P, Schoeters G, et al. Lead neurotoxicity in children: is prenatal exposure more important than postnatal exposure? Acta Paediatr Suppl. 2006;95(453):45-9.
Ronchetti, R., van den Hazel, P., Schoeters, G., Hanke, W., Rennezova, Z., Barreto, M., & Villa, M. P. (2006). Lead neurotoxicity in children: is prenatal exposure more important than postnatal exposure? Acta Paediatrica (Oslo, Norway : 1992). Supplement, 95(453), 45-9.
Ronchetti R, et al. Lead Neurotoxicity in Children: Is Prenatal Exposure More Important Than Postnatal Exposure. Acta Paediatr Suppl. 2006;95(453):45-9. PubMed PMID: 17000569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Lead neurotoxicity in children: is prenatal exposure more important than postnatal exposure? AU - Ronchetti,Roberto, AU - van den Hazel,Peter, AU - Schoeters,Greet, AU - Hanke,Wojtek, AU - Rennezova,Zusana, AU - Barreto,Mario, AU - Villa,Maria Pia, PY - 2006/9/27/pubmed PY - 2007/3/23/medline PY - 2006/9/27/entrez SP - 45 EP - 9 JF - Acta paediatrica (Oslo, Norway : 1992). Supplement JO - Acta Paediatr Suppl VL - 95 IS - 453 N2 - Numerous studies indicate that low-level lead poisoning causes mild mental retardation and low IQ scores in children. The general mean lead intake in the adult European population corresponds to a reassuring 14% (0.5-56%) of the tolerable daily intake: at this low level of exposure only few children (less than 10%) have blood lead levels (PbB) higher than 10 microg/dl, previously considered the PbB of concern. In more recent years data now suggest that even when 'the lifetime average blood lead concentration' is below 10 microg/dl an inverse association exists with intelligence quotient (IQ) scores. Two-thirds (45-75%) of lead in blood, however, comes from long-term tissue stores and this is especially true for newborn infants and pregnant women. Several data suggest that for lead the main toxic event is prenatal exposure: therefore we should focus our attention on maternal lead stores and whenever possible avoid their mobilization during pregnancy. In this regard we should design appropriate studies to confirm whether dietary supplementations can reduce bone resorption and lead mobilization during pregnancy. The hypothesis that the amount of maternal bone lead stores is the relevant parameter for predicting the level of neurotoxicity of this metal gives some optimism for the future: if we study children whose mothers never underwent high environmental pollution (born after the withdrawal of lead from gasoline) and hence have relatively low bone lead stores we could find that, at the population level, lead has little influence on children IQ scores. SN - 0803-5326 UR - https://www.unboundmedicine.com/medline/citation/17000569/Lead_neurotoxicity_in_children:_is_prenatal_exposure_more_important_than_postnatal_exposure L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=17000569.ui DB - PRIME DP - Unbound Medicine ER -