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Comparative analysis of HBV and HCV infection in hepatocellular carcinoma and chronic liver disease--an autopsy based study.
Indian J Pathol Microbiol. 2006 Jul; 49(3):357-61.IJ

Abstract

Hepatocellular carcinoma (HCC) is one of the common malignancies worldwide including Asian countries. Chronic viral hepatitis is implicated as an important etiological factor in carcinogenesis of liver.

AIM

To study incidence of hepatitis B (HBV) and C (HCV) viruses in HCC and to compare the incidences with that of chronic liver disease.

MATERIALS AND METHOD

40 cases each of HCC (group I) and chronic liver disease including cirrhotic liver (group II) who died of the liver disease. All cases were stained with HBsAg and HBcAb for HBV and RT-PCR for HCV RNA. Different groups were compared using student's t-paired and chi-square tests.

RESULTS

Group I--HCC was seen in 37 cirrhotics and 3 non-cirrhotic cases. HBsAg was positive in 32 cases (80%), HBcAb in 22 cases (55%) and HCV in 23 cases (57.5%) (p<0.05). Dysplastic nodule (DN) was seen in 25 cases, HBsAg and HBcAg positivity were seen in 18 and 15 cases respectively. Group II--32 cases were cirrhotic and 8 were non-cirrhotics. HBsAg was positive in 28 (70%), HBcAb in 12 (30%) and HCV in 18 (45%) cases. DN was seen 24 cases, HBsAg and HBcAg postiviy were seen in 16 and 7 cases respectively. HBV and HCV co-infection was seen in 20 and 15 cases, and HCV with HBcAb positivity was seen in 13 and 9 cases in groups I and II respectively. Number of cells in each case showing positivity for HBcAb was also significantly higher in group I (p<0.01). Age and sex distribution did not show any distinctive differences between the two groups.

CONCLUSION

the study highlights a high incidence ofHBVand HCV infection in cases of chronic liver disease and HCC. HBcAb positive state appears to be an independent risk factor for HCC.

Authors+Show Affiliations

Department of Histopathology, PGIMER, Chandigarh. kimv@glide.net.inNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17001884

Citation

Vaiphei, Kim, et al. "Comparative Analysis of HBV and HCV Infection in Hepatocellular Carcinoma and Chronic Liver Disease--an Autopsy Based Study." Indian Journal of Pathology & Microbiology, vol. 49, no. 3, 2006, pp. 357-61.
Vaiphei K, Pal NS, Arora SK. Comparative analysis of HBV and HCV infection in hepatocellular carcinoma and chronic liver disease--an autopsy based study. Indian J Pathol Microbiol. 2006;49(3):357-61.
Vaiphei, K., Pal, N. S., & Arora, S. K. (2006). Comparative analysis of HBV and HCV infection in hepatocellular carcinoma and chronic liver disease--an autopsy based study. Indian Journal of Pathology & Microbiology, 49(3), 357-61.
Vaiphei K, Pal NS, Arora SK. Comparative Analysis of HBV and HCV Infection in Hepatocellular Carcinoma and Chronic Liver Disease--an Autopsy Based Study. Indian J Pathol Microbiol. 2006;49(3):357-61. PubMed PMID: 17001884.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative analysis of HBV and HCV infection in hepatocellular carcinoma and chronic liver disease--an autopsy based study. AU - Vaiphei,Kim, AU - Pal,Nirbhai S, AU - Arora,Sunil K, PY - 2006/9/28/pubmed PY - 2006/10/25/medline PY - 2006/9/28/entrez SP - 357 EP - 61 JF - Indian journal of pathology & microbiology JO - Indian J Pathol Microbiol VL - 49 IS - 3 N2 - UNLABELLED: Hepatocellular carcinoma (HCC) is one of the common malignancies worldwide including Asian countries. Chronic viral hepatitis is implicated as an important etiological factor in carcinogenesis of liver. AIM: To study incidence of hepatitis B (HBV) and C (HCV) viruses in HCC and to compare the incidences with that of chronic liver disease. MATERIALS AND METHOD: 40 cases each of HCC (group I) and chronic liver disease including cirrhotic liver (group II) who died of the liver disease. All cases were stained with HBsAg and HBcAb for HBV and RT-PCR for HCV RNA. Different groups were compared using student's t-paired and chi-square tests. RESULTS: Group I--HCC was seen in 37 cirrhotics and 3 non-cirrhotic cases. HBsAg was positive in 32 cases (80%), HBcAb in 22 cases (55%) and HCV in 23 cases (57.5%) (p<0.05). Dysplastic nodule (DN) was seen in 25 cases, HBsAg and HBcAg positivity were seen in 18 and 15 cases respectively. Group II--32 cases were cirrhotic and 8 were non-cirrhotics. HBsAg was positive in 28 (70%), HBcAb in 12 (30%) and HCV in 18 (45%) cases. DN was seen 24 cases, HBsAg and HBcAg postiviy were seen in 16 and 7 cases respectively. HBV and HCV co-infection was seen in 20 and 15 cases, and HCV with HBcAb positivity was seen in 13 and 9 cases in groups I and II respectively. Number of cells in each case showing positivity for HBcAb was also significantly higher in group I (p<0.01). Age and sex distribution did not show any distinctive differences between the two groups. CONCLUSION: the study highlights a high incidence ofHBVand HCV infection in cases of chronic liver disease and HCC. HBcAb positive state appears to be an independent risk factor for HCC. SN - 0377-4929 UR - https://www.unboundmedicine.com/medline/citation/17001884/Comparative_analysis_of_HBV_and_HCV_infection_in_hepatocellular_carcinoma_and_chronic_liver_disease__an_autopsy_based_study_ L2 - http://www.diseaseinfosearch.org/result/4280 DB - PRIME DP - Unbound Medicine ER -