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Topical immunotherapy with diphenylcyclopropenone in the treatment of chronic extensive alopecia areata.
Clin Exp Dermatol. 2007 Jan; 32(1):48-51.CE

Abstract

Highly variable results have been described for the use of topical diphenylcyclopropenone (DPCP) in the treatment of alopecia areata (AA). We enrolled 41 patients in a prospective open clinical trial. Of these, 17 patients had either AA totalis (AAT) or AA universalis (AAU), and 24 had severe alopecia (> 50% scalp involvement). After sensitization with DPCP 2% in acetone, progressively higher concentrations were applied once a week for a period of 6-12 months. Of the 41 patients, 38 (16 with AAT or AAU and 22 with extensive AA) completed therapy. Significant hair regrowth was observed in 15 of the 38 patients (39.5%) at 6 months: 5 with AAT or AAU (31.25%) and 10 with extensive alopecia (45.4%). The above results were sustained in 66.6% of patients for a 12-month-follow up- period. In our study, topical immunotherapy with DPCP proved to be an effective treatment, with prolonged therapeutic results.

Authors+Show Affiliations

First Department of Dermatology, Aristotle University of Thessaloniki, Greece.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17004987

Citation

Sotiriadis, D, et al. "Topical Immunotherapy With Diphenylcyclopropenone in the Treatment of Chronic Extensive Alopecia Areata." Clinical and Experimental Dermatology, vol. 32, no. 1, 2007, pp. 48-51.
Sotiriadis D, Patsatsi A, Lazaridou E, et al. Topical immunotherapy with diphenylcyclopropenone in the treatment of chronic extensive alopecia areata. Clin Exp Dermatol. 2007;32(1):48-51.
Sotiriadis, D., Patsatsi, A., Lazaridou, E., Kastanis, A., Vakirlis, E., & Chrysomallis, F. (2007). Topical immunotherapy with diphenylcyclopropenone in the treatment of chronic extensive alopecia areata. Clinical and Experimental Dermatology, 32(1), 48-51.
Sotiriadis D, et al. Topical Immunotherapy With Diphenylcyclopropenone in the Treatment of Chronic Extensive Alopecia Areata. Clin Exp Dermatol. 2007;32(1):48-51. PubMed PMID: 17004987.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Topical immunotherapy with diphenylcyclopropenone in the treatment of chronic extensive alopecia areata. AU - Sotiriadis,D, AU - Patsatsi,A, AU - Lazaridou,E, AU - Kastanis,A, AU - Vakirlis,E, AU - Chrysomallis,F, Y1 - 2006/09/27/ PY - 2006/9/29/pubmed PY - 2007/7/11/medline PY - 2006/9/29/entrez SP - 48 EP - 51 JF - Clinical and experimental dermatology JO - Clin Exp Dermatol VL - 32 IS - 1 N2 - Highly variable results have been described for the use of topical diphenylcyclopropenone (DPCP) in the treatment of alopecia areata (AA). We enrolled 41 patients in a prospective open clinical trial. Of these, 17 patients had either AA totalis (AAT) or AA universalis (AAU), and 24 had severe alopecia (> 50% scalp involvement). After sensitization with DPCP 2% in acetone, progressively higher concentrations were applied once a week for a period of 6-12 months. Of the 41 patients, 38 (16 with AAT or AAU and 22 with extensive AA) completed therapy. Significant hair regrowth was observed in 15 of the 38 patients (39.5%) at 6 months: 5 with AAT or AAU (31.25%) and 10 with extensive alopecia (45.4%). The above results were sustained in 66.6% of patients for a 12-month-follow up- period. In our study, topical immunotherapy with DPCP proved to be an effective treatment, with prolonged therapeutic results. SN - 0307-6938 UR - https://www.unboundmedicine.com/medline/citation/17004987/Topical_immunotherapy_with_diphenylcyclopropenone_in_the_treatment_of_chronic_extensive_alopecia_areata_ L2 - https://doi.org/10.1111/j.1365-2230.2006.02256.x DB - PRIME DP - Unbound Medicine ER -