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Intraplacental choriocarcinoma in a term placenta with both maternal and infantile metastases: a case report and review of the literature.
Gynecol Oncol. 2006 Dec; 103(3):1147-51.GO

Abstract

BACKGROUND

Intraplacental choriocarcinoma is rare, and usually results in maternal metastasis at the time of diagnosis. Intraplacental choriocarcinoma involves both mother and infant is extremely rare. There was only one case report of intraplacental choriocarcinoma with confirmed metastases involving both the mother and the infant.

CASE

We describe a second case of intraplacental choriocarcinoma in a term placenta with both maternal and infantile metastases. Grossly, the primary lesion of the placenta resembled an old infarct. Microscopically, clusters of malignant trophoblasts arose from residual normal chorionic villi and infiltrated into the intervillous spaces. Both the mother and the infant received chemotherapy and were alive without disease after one year's follow-up.

CONCLUSION

The optimal treatment for intraplacental choriocarcinoma is controversial. However, aggressive chemotherapy is suggested for patients with metastatic disease.

Authors+Show Affiliations

Department of Pathology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, P.R. China.No affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

17005243

Citation

Liu, Jianping, and Lina Guo. "Intraplacental Choriocarcinoma in a Term Placenta With Both Maternal and Infantile Metastases: a Case Report and Review of the Literature." Gynecologic Oncology, vol. 103, no. 3, 2006, pp. 1147-51.
Liu J, Guo L. Intraplacental choriocarcinoma in a term placenta with both maternal and infantile metastases: a case report and review of the literature. Gynecol Oncol. 2006;103(3):1147-51.
Liu, J., & Guo, L. (2006). Intraplacental choriocarcinoma in a term placenta with both maternal and infantile metastases: a case report and review of the literature. Gynecologic Oncology, 103(3), 1147-51.
Liu J, Guo L. Intraplacental Choriocarcinoma in a Term Placenta With Both Maternal and Infantile Metastases: a Case Report and Review of the Literature. Gynecol Oncol. 2006;103(3):1147-51. PubMed PMID: 17005243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intraplacental choriocarcinoma in a term placenta with both maternal and infantile metastases: a case report and review of the literature. AU - Liu,Jianping, AU - Guo,Lina, Y1 - 2006/09/26/ PY - 2006/04/28/received PY - 2006/07/25/revised PY - 2006/08/06/accepted PY - 2006/9/29/pubmed PY - 2007/1/20/medline PY - 2006/9/29/entrez SP - 1147 EP - 51 JF - Gynecologic oncology JO - Gynecol Oncol VL - 103 IS - 3 N2 - BACKGROUND: Intraplacental choriocarcinoma is rare, and usually results in maternal metastasis at the time of diagnosis. Intraplacental choriocarcinoma involves both mother and infant is extremely rare. There was only one case report of intraplacental choriocarcinoma with confirmed metastases involving both the mother and the infant. CASE: We describe a second case of intraplacental choriocarcinoma in a term placenta with both maternal and infantile metastases. Grossly, the primary lesion of the placenta resembled an old infarct. Microscopically, clusters of malignant trophoblasts arose from residual normal chorionic villi and infiltrated into the intervillous spaces. Both the mother and the infant received chemotherapy and were alive without disease after one year's follow-up. CONCLUSION: The optimal treatment for intraplacental choriocarcinoma is controversial. However, aggressive chemotherapy is suggested for patients with metastatic disease. SN - 0090-8258 UR - https://www.unboundmedicine.com/medline/citation/17005243/Intraplacental_choriocarcinoma_in_a_term_placenta_with_both_maternal_and_infantile_metastases:_a_case_report_and_review_of_the_literature_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0090-8258(06)00620-2 DB - PRIME DP - Unbound Medicine ER -