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Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients.
Int J Cardiol. 2007 May 31; 118(2):173-7.IJ

Abstract

BACKGROUND

Statins are known to possess antioxidant properties in addition to their cholesterol-lowering effects. However, recent studies have suggested that statins reduce the levels of antioxidant vitamins such as vitamin E and coenzyme Q(10), possibly resulting in impaired left ventricular function. We investigated the effects of simvastatin on the blood lipids, LDL oxidation and plasma antioxidant status, and whether these effects were associated with changes in plasma antioxidant vitamin levels.

METHODS

Simvastatin (20-40 mg/day) was administered for 8 weeks in seventy-six hypercholesterolemic patients. We measured plasma lipids, oxidized LDL, total radical trapping antioxidant potential (TRAP) and plasma antioxidant vitamin levels at baseline and after 8 weeks of simvastatin administration.

RESULTS

Simvastatin significantly lowered serum levels of total cholesterol and LDL-cholesterol by 30.1% and 41.9%, respectively. A significant reduction in oxidized LDL levels (p<0.0001) and improvement in plasma antioxidant status as measured by TRAP (p<0.05) after the 8-week simvastatin treatment were observed. Regarding the effects of simvastatin on plasma antioxidant vitamin levels, there were significant increases in the levels of lipid-corrected retinol (p<0.001), alpha-tocopherol (p<0.001) and gamma-tocopherol (p<0.005) after the 8-week simvastatin treatment. Lipid-corrected levels of coenzyme Q10 and carotenoids remained unchanged after simvastatin treatment.

CONCLUSIONS

Our results show that simvastatin reduced blood lipids and circulating oxidized LDL, and improved plasma antioxidant status without altering the antioxidant vitamin system. These data indicate that simvastatin not only decreases blood lipids and circulating oxidized LDL but also increases lipid corrected levels of antioxidant vitamins and may improve plasma antioxidant status synergizing with the biological effects of antioxidants.

Authors+Show Affiliations

Yonsei Cardiovascular Research Institute, Yonsei University College of Medicine, Seoul 120-752, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17005272

Citation

Shin, Min-Jeong, et al. "Effects of Simvastatin On Plasma Antioxidant Status and Vitamins in Hypercholesterolemic Patients." International Journal of Cardiology, vol. 118, no. 2, 2007, pp. 173-7.
Shin MJ, Chung N, Lee JH, et al. Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients. Int J Cardiol. 2007;118(2):173-7.
Shin, M. J., Chung, N., Lee, J. H., Jang, Y., Park, E., Jeon, K. I., Chung, J. H., & Seo, B. Y. (2007). Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients. International Journal of Cardiology, 118(2), 173-7.
Shin MJ, et al. Effects of Simvastatin On Plasma Antioxidant Status and Vitamins in Hypercholesterolemic Patients. Int J Cardiol. 2007 May 31;118(2):173-7. PubMed PMID: 17005272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of simvastatin on plasma antioxidant status and vitamins in hypercholesterolemic patients. AU - Shin,Min-Jeong, AU - Chung,Namsik, AU - Lee,Jong Ho, AU - Jang,Yangsoo, AU - Park,Eunju, AU - Jeon,Kyung-Im, AU - Chung,Ji Hyung, AU - Seo,Bo-Young, Y1 - 2006/09/26/ PY - 2005/12/15/received PY - 2005/12/15/revised PY - 2006/03/11/accepted PY - 2006/9/29/pubmed PY - 2007/8/23/medline PY - 2006/9/29/entrez SP - 173 EP - 7 JF - International journal of cardiology JO - Int J Cardiol VL - 118 IS - 2 N2 - BACKGROUND: Statins are known to possess antioxidant properties in addition to their cholesterol-lowering effects. However, recent studies have suggested that statins reduce the levels of antioxidant vitamins such as vitamin E and coenzyme Q(10), possibly resulting in impaired left ventricular function. We investigated the effects of simvastatin on the blood lipids, LDL oxidation and plasma antioxidant status, and whether these effects were associated with changes in plasma antioxidant vitamin levels. METHODS: Simvastatin (20-40 mg/day) was administered for 8 weeks in seventy-six hypercholesterolemic patients. We measured plasma lipids, oxidized LDL, total radical trapping antioxidant potential (TRAP) and plasma antioxidant vitamin levels at baseline and after 8 weeks of simvastatin administration. RESULTS: Simvastatin significantly lowered serum levels of total cholesterol and LDL-cholesterol by 30.1% and 41.9%, respectively. A significant reduction in oxidized LDL levels (p<0.0001) and improvement in plasma antioxidant status as measured by TRAP (p<0.05) after the 8-week simvastatin treatment were observed. Regarding the effects of simvastatin on plasma antioxidant vitamin levels, there were significant increases in the levels of lipid-corrected retinol (p<0.001), alpha-tocopherol (p<0.001) and gamma-tocopherol (p<0.005) after the 8-week simvastatin treatment. Lipid-corrected levels of coenzyme Q10 and carotenoids remained unchanged after simvastatin treatment. CONCLUSIONS: Our results show that simvastatin reduced blood lipids and circulating oxidized LDL, and improved plasma antioxidant status without altering the antioxidant vitamin system. These data indicate that simvastatin not only decreases blood lipids and circulating oxidized LDL but also increases lipid corrected levels of antioxidant vitamins and may improve plasma antioxidant status synergizing with the biological effects of antioxidants. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/17005272/Effects_of_simvastatin_on_plasma_antioxidant_status_and_vitamins_in_hypercholesterolemic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(06)00780-7 DB - PRIME DP - Unbound Medicine ER -