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Disturbances of visual information processing in early states of psychosis and experimental delta-9-tetrahydrocannabinol altered states of consciousness.

Abstract

Recent data on alterations of the endogenous cannabinoid system in schizophrenia have raised the question of its functional role in this disease. The psychoactive compound of Cannabis sativa, delta-9-tetrahydrocannabinol (Delta9-THC), has been shown to induce psychotic symptoms, but it is unknown to what extend prodromal states of psychoses are reflected by these experimental approaches. This study compares four groups of subjects: antipsychotic-naïve patients suffering from acute paranoid schizophrenic or schizophreniform psychosis (SZ), patients in the prodromal state (IPS), healthy controls without any pharmacological intervention (HC) and a second group of healthy volunteers who were orally administered synthetic Delta9-THC (Dronabinol) (HC-THC). Neither SZ and IPS nor HC received the experimental drug. All subjects were assessed using the Brief Psychiatric Rating Scale (BPRS) and the Binocular Depth Inversion Illusion Test (BDII). The latter represents a sensitive measure of impaired visual information processing that manifests in various experimental and naturally occurring psychotic states. BDII values were well comparable in SZ, IPS and HC-THC, and all groups differed significantly to HC. The BPRS revealed no significant difference between HC-THC and IPS while both were significantly different from SZ and HC, respectively. Our results suggest that Delta9-THC-induced altered states of consciousness may serve as a useful tool for modeling psychotic disorders, particularly their prodromal states. Furthermore, they provide insight into the perceptual and psychopathological alterations induced by Delta9-THC, which is essential for the understanding of the pro-psychotic effects of herbal cannabis preparations with highly enriched Delta9-THC content.

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  • Authors+Show Affiliations

    ,

    Department of Psychiatry and Psychotherapy, University of Cologne, 50924 Cologne, Germany.

    , , , , , , , ,

    Source

    Schizophrenia research 88:1-3 2006 Dec pg 142-50

    MeSH

    Acute Disease
    Adolescent
    Adult
    Brief Psychiatric Rating Scale
    Consciousness Disorders
    Depth Perception
    Dronabinol
    Female
    Hallucinogens
    Humans
    Male
    Perceptual Disorders
    Psychometrics
    Psychoses, Substance-Induced
    Schizophrenia, Paranoid
    Severity of Illness Index
    Vision, Binocular
    Visual Perception

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17005373

    Citation

    Koethe, Dagmar, et al. "Disturbances of Visual Information Processing in Early States of Psychosis and Experimental Delta-9-tetrahydrocannabinol Altered States of Consciousness." Schizophrenia Research, vol. 88, no. 1-3, 2006, pp. 142-50.
    Koethe D, Gerth CW, Neatby MA, et al. Disturbances of visual information processing in early states of psychosis and experimental delta-9-tetrahydrocannabinol altered states of consciousness. Schizophr Res. 2006;88(1-3):142-50.
    Koethe, D., Gerth, C. W., Neatby, M. A., Haensel, A., Thies, M., Schneider, U., ... Leweke, F. M. (2006). Disturbances of visual information processing in early states of psychosis and experimental delta-9-tetrahydrocannabinol altered states of consciousness. Schizophrenia Research, 88(1-3), pp. 142-50.
    Koethe D, et al. Disturbances of Visual Information Processing in Early States of Psychosis and Experimental Delta-9-tetrahydrocannabinol Altered States of Consciousness. Schizophr Res. 2006;88(1-3):142-50. PubMed PMID: 17005373.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Disturbances of visual information processing in early states of psychosis and experimental delta-9-tetrahydrocannabinol altered states of consciousness. AU - Koethe,Dagmar, AU - Gerth,Christoph W, AU - Neatby,Miriam A, AU - Haensel,Anita, AU - Thies,Martin, AU - Schneider,Udo, AU - Emrich,Hinderk M, AU - Klosterkötter,Joachim, AU - Schultze-Lutter,Frauke, AU - Leweke,F Markus, Y1 - 2006/09/26/ PY - 2006/02/22/received PY - 2006/07/24/revised PY - 2006/07/28/accepted PY - 2006/9/29/pubmed PY - 2007/2/7/medline PY - 2006/9/29/entrez SP - 142 EP - 50 JF - Schizophrenia research JO - Schizophr. Res. VL - 88 IS - 1-3 N2 - Recent data on alterations of the endogenous cannabinoid system in schizophrenia have raised the question of its functional role in this disease. The psychoactive compound of Cannabis sativa, delta-9-tetrahydrocannabinol (Delta9-THC), has been shown to induce psychotic symptoms, but it is unknown to what extend prodromal states of psychoses are reflected by these experimental approaches. This study compares four groups of subjects: antipsychotic-naïve patients suffering from acute paranoid schizophrenic or schizophreniform psychosis (SZ), patients in the prodromal state (IPS), healthy controls without any pharmacological intervention (HC) and a second group of healthy volunteers who were orally administered synthetic Delta9-THC (Dronabinol) (HC-THC). Neither SZ and IPS nor HC received the experimental drug. All subjects were assessed using the Brief Psychiatric Rating Scale (BPRS) and the Binocular Depth Inversion Illusion Test (BDII). The latter represents a sensitive measure of impaired visual information processing that manifests in various experimental and naturally occurring psychotic states. BDII values were well comparable in SZ, IPS and HC-THC, and all groups differed significantly to HC. The BPRS revealed no significant difference between HC-THC and IPS while both were significantly different from SZ and HC, respectively. Our results suggest that Delta9-THC-induced altered states of consciousness may serve as a useful tool for modeling psychotic disorders, particularly their prodromal states. Furthermore, they provide insight into the perceptual and psychopathological alterations induced by Delta9-THC, which is essential for the understanding of the pro-psychotic effects of herbal cannabis preparations with highly enriched Delta9-THC content. SN - 0920-9964 UR - https://www.unboundmedicine.com/medline/citation/17005373/Disturbances_of_visual_information_processing_in_early_states_of_psychosis_and_experimental_delta_9_tetrahydrocannabinol_altered_states_of_consciousness_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0920-9964(06)00352-5 DB - PRIME DP - Unbound Medicine ER -