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Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses.
J Neurophysiol. 2006 Dec; 96(6):3114-21.JN

Abstract

Our laboratory recently characterized a form of long-term depression (LTD) at CA3-CA1 synapses mediated by M1 muscarinic receptors (mAChRs), termed muscarinic LTD (mLTD). mLTD is both activity and NMDAR dependent, characteristics shared by forms of synaptic plasticity thought to be relevant to learning and memory, including long-term potentiation (LTP) induced by high-frequency stimulation (HFS-LTP) and long-term depression induced by low-frequency stimulation (LFS-LTD). However, it remains unclear whether mLTD can occur sequentially with these electrically induced forms of hippocampal plasticity or whether mLTD might interact with them. The first goal of this study was to examine the interplay of mLTD and HFS-LTP. We report that mLTD expression does not alter subsequent induction of HFS-LTP and, further, at synapses expressing HFS-LTP, mLTD can mediate a novel form of depotentiation. The second goal was to determine whether mLTD would alter LFS-LTD induction and/or expression. Although we show that mLTD is occluded by saturation of LFS-LTD, suggesting mechanistic similarity between these two plasticities, saturation of mLTD does not occlude LFS-LTD. Surprisingly, however, the LFS-LTD that follows cholinergic receptor activation is NMDAR independent, indicating that application of muscarinic agonist induces a change in the induction mechanism required for LFS-LTD. These data demonstrate that mLTD can coexist with electrically induced forms of synaptic plasticity and support the hypothesis that mLTD is one of the mechanisms by which the cholinergic system modulates hippocampal function.

Authors+Show Affiliations

The University of Alabama at Birmingham, 1918 University Blvd, MCLM 964, Birmingham, AL 35294-0005, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17005622

Citation

McCutchen, Eve, et al. "Coexistence of Muscarinic Long-term Depression With Electrically Induced Long-term Potentiation and Depression at CA3-CA1 Synapses." Journal of Neurophysiology, vol. 96, no. 6, 2006, pp. 3114-21.
McCutchen E, Scheiderer CL, Dobrunz LE, et al. Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses. J Neurophysiol. 2006;96(6):3114-21.
McCutchen, E., Scheiderer, C. L., Dobrunz, L. E., & McMahon, L. L. (2006). Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses. Journal of Neurophysiology, 96(6), 3114-21.
McCutchen E, et al. Coexistence of Muscarinic Long-term Depression With Electrically Induced Long-term Potentiation and Depression at CA3-CA1 Synapses. J Neurophysiol. 2006;96(6):3114-21. PubMed PMID: 17005622.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Coexistence of muscarinic long-term depression with electrically induced long-term potentiation and depression at CA3-CA1 synapses. AU - McCutchen,Eve, AU - Scheiderer,Cary L, AU - Dobrunz,Lynn E, AU - McMahon,Lori L, Y1 - 2006/09/27/ PY - 2006/9/29/pubmed PY - 2007/1/18/medline PY - 2006/9/29/entrez SP - 3114 EP - 21 JF - Journal of neurophysiology JO - J Neurophysiol VL - 96 IS - 6 N2 - Our laboratory recently characterized a form of long-term depression (LTD) at CA3-CA1 synapses mediated by M1 muscarinic receptors (mAChRs), termed muscarinic LTD (mLTD). mLTD is both activity and NMDAR dependent, characteristics shared by forms of synaptic plasticity thought to be relevant to learning and memory, including long-term potentiation (LTP) induced by high-frequency stimulation (HFS-LTP) and long-term depression induced by low-frequency stimulation (LFS-LTD). However, it remains unclear whether mLTD can occur sequentially with these electrically induced forms of hippocampal plasticity or whether mLTD might interact with them. The first goal of this study was to examine the interplay of mLTD and HFS-LTP. We report that mLTD expression does not alter subsequent induction of HFS-LTP and, further, at synapses expressing HFS-LTP, mLTD can mediate a novel form of depotentiation. The second goal was to determine whether mLTD would alter LFS-LTD induction and/or expression. Although we show that mLTD is occluded by saturation of LFS-LTD, suggesting mechanistic similarity between these two plasticities, saturation of mLTD does not occlude LFS-LTD. Surprisingly, however, the LFS-LTD that follows cholinergic receptor activation is NMDAR independent, indicating that application of muscarinic agonist induces a change in the induction mechanism required for LFS-LTD. These data demonstrate that mLTD can coexist with electrically induced forms of synaptic plasticity and support the hypothesis that mLTD is one of the mechanisms by which the cholinergic system modulates hippocampal function. SN - 0022-3077 UR - https://www.unboundmedicine.com/medline/citation/17005622/Coexistence_of_muscarinic_long_term_depression_with_electrically_induced_long_term_potentiation_and_depression_at_CA3_CA1_synapses_ L2 - https://journals.physiology.org/doi/10.1152/jn.00144.2006?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -