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Nutrient intake and risk of non-Hodgkin's lymphoma.

Abstract

The mechanisms through which diet may influence the development of non-Hodgkin's lymphoma (NHL) are unclear but can be better understood by examining associations between nutrient consumption and NHL risk. Between 2000 and 2002, 591 NHL cases and 460 population-based controls in Sweden completed a semiquantitative food frequency questionnaire. Unconditional logistic regression was performed to estimate odds ratios and 95% confidence intervals for associations with nutrient intake; all statistical tests were two sided. Dietary intake of most macronutrients was not associated with risk of NHL or its common subtypes. Consumption of omega-3 or marine fatty acids was associated with decreased risk of NHL and chronic lymphocytic lymphoma, and dietary fiber was associated with lower risk of all subtypes examined. When the highest and the lowest quartiles of marine fat intake were compared, the odds ratio for NHL risk was 0.6 (95% confidence interval: 0.4, 0.9), ptrend=0.03; for dietary fiber intake, the corresponding odds ratio was 0.5 (95% confidence interval: 0.3, 0.7), ptrend<0.001. Dietary consumption of beta-carotene or alpha-tocopherol was associated with lower NHL risk, whereas intake of calcium or retinol was associated with increased NHL risk. Nutrients that affect inflammation, vitamin D activity, oxidative DNA damage, or DNA methylation may be associated with risk of NHL.

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  • Authors+Show Affiliations

    ,

    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. ellen@nccc.org

    , , , , , ,

    Source

    American journal of epidemiology 164:12 2006 Dec 15 pg 1222-32

    MeSH

    Adolescent
    Adult
    Aged
    Case-Control Studies
    Diet
    Diet Surveys
    Dietary Fats
    Dietary Fiber
    Energy Intake
    Female
    Humans
    Lymphoma, Non-Hodgkin
    Male
    Middle Aged
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17005624

    Citation

    Chang, Ellen T., et al. "Nutrient Intake and Risk of non-Hodgkin's Lymphoma." American Journal of Epidemiology, vol. 164, no. 12, 2006, pp. 1222-32.
    Chang ET, Bälter KM, Torrång A, et al. Nutrient intake and risk of non-Hodgkin's lymphoma. Am J Epidemiol. 2006;164(12):1222-32.
    Chang, E. T., Bälter, K. M., Torrång, A., Smedby, K. E., Melbye, M., Sundström, C., ... Adami, H. O. (2006). Nutrient intake and risk of non-Hodgkin's lymphoma. American Journal of Epidemiology, 164(12), pp. 1222-32.
    Chang ET, et al. Nutrient Intake and Risk of non-Hodgkin's Lymphoma. Am J Epidemiol. 2006 Dec 15;164(12):1222-32. PubMed PMID: 17005624.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Nutrient intake and risk of non-Hodgkin's lymphoma. AU - Chang,Ellen T, AU - Bälter,Katarina M, AU - Torrång,Anna, AU - Smedby,Karin Ekström, AU - Melbye,Mads, AU - Sundström,Christer, AU - Glimelius,Bengt, AU - Adami,Hans-Olov, Y1 - 2006/09/27/ PY - 2006/9/29/pubmed PY - 2007/1/20/medline PY - 2006/9/29/entrez SP - 1222 EP - 32 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 164 IS - 12 N2 - The mechanisms through which diet may influence the development of non-Hodgkin's lymphoma (NHL) are unclear but can be better understood by examining associations between nutrient consumption and NHL risk. Between 2000 and 2002, 591 NHL cases and 460 population-based controls in Sweden completed a semiquantitative food frequency questionnaire. Unconditional logistic regression was performed to estimate odds ratios and 95% confidence intervals for associations with nutrient intake; all statistical tests were two sided. Dietary intake of most macronutrients was not associated with risk of NHL or its common subtypes. Consumption of omega-3 or marine fatty acids was associated with decreased risk of NHL and chronic lymphocytic lymphoma, and dietary fiber was associated with lower risk of all subtypes examined. When the highest and the lowest quartiles of marine fat intake were compared, the odds ratio for NHL risk was 0.6 (95% confidence interval: 0.4, 0.9), ptrend=0.03; for dietary fiber intake, the corresponding odds ratio was 0.5 (95% confidence interval: 0.3, 0.7), ptrend<0.001. Dietary consumption of beta-carotene or alpha-tocopherol was associated with lower NHL risk, whereas intake of calcium or retinol was associated with increased NHL risk. Nutrients that affect inflammation, vitamin D activity, oxidative DNA damage, or DNA methylation may be associated with risk of NHL. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17005624/Nutrient_intake_and_risk_of_non_Hodgkin's_lymphoma_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwj330 DB - PRIME DP - Unbound Medicine ER -