Tags

Type your tag names separated by a space and hit enter

Transmission of human herpesvirus 8 by blood transfusion.
N Engl J Med. 2006 Sep 28; 355(13):1331-8.NEJM

Abstract

BACKGROUND

Whether human herpesvirus 8 (HHV-8) is transmissible by blood transfusion remains undetermined. We evaluated the risk of HHV-8 transmission by blood transfusion in Uganda, where HHV-8 is endemic.

METHODS

We enrolled patients in Kampala, Uganda, who had received blood transfusions between December 2000 and October 2001. Pretransfusion and multiple post-transfusion blood specimens from up to nine visits over a 6-month period were tested for HHV-8 antibody. We calculated the excess risk of seroconversion over time among recipients of HHV-8-seropositive blood as compared with recipients of seronegative blood.

RESULTS

Of the 1811 transfusion recipients enrolled, 991 were HHV-8-seronegative before transfusion and completed the requisite follow-up, 43% of whom received HHV-8-seropositive blood and 57% of whom received seronegative blood. HHV-8 seroconversion occurred in 41 of the 991 recipients. The risk of seroconversion was significantly higher among recipients of HHV-8-seropositive blood than among recipients of seronegative blood (excess risk, 2.8%; P<0.05), and the increase in risk was seen mainly among patients in whom seroconversion occurred 3 to 10 weeks after transfusion (excess risk, 2.7%; P=0.005), a result consistent with the transmission of the virus by transfusion. Blood units stored for up to 4 days were more often associated with seroconversion than those stored for more than 4 days (excess risk, 4.2%; P<0.05).

CONCLUSIONS

This study provides strong evidence that HHV-8 is transmitted by blood transfusion. The risk may be diminished as the period of blood storage increases.

Authors+Show Affiliations

Global Acquired Immunodeficiency Syndrome Program, National Center for Human Immunodeficiency Virus, Sexually Transmitted Diseases, and Tuberculosis Prevention, Centers for Disease Control and Prevention, Entebbe, Uganda.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

17005950

Citation

Hladik, Wolfgang, et al. "Transmission of Human Herpesvirus 8 By Blood Transfusion." The New England Journal of Medicine, vol. 355, no. 13, 2006, pp. 1331-8.
Hladik W, Dollard SC, Mermin J, et al. Transmission of human herpesvirus 8 by blood transfusion. N Engl J Med. 2006;355(13):1331-8.
Hladik, W., Dollard, S. C., Mermin, J., Fowlkes, A. L., Downing, R., Amin, M. M., Banage, F., Nzaro, E., Kataaha, P., Dondero, T. J., Pellett, P. E., & Lackritz, E. M. (2006). Transmission of human herpesvirus 8 by blood transfusion. The New England Journal of Medicine, 355(13), 1331-8.
Hladik W, et al. Transmission of Human Herpesvirus 8 By Blood Transfusion. N Engl J Med. 2006 Sep 28;355(13):1331-8. PubMed PMID: 17005950.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Transmission of human herpesvirus 8 by blood transfusion. AU - Hladik,Wolfgang, AU - Dollard,Sheila C, AU - Mermin,Jonathan, AU - Fowlkes,Ashley L, AU - Downing,Robert, AU - Amin,Minal M, AU - Banage,Flora, AU - Nzaro,Esau, AU - Kataaha,Peter, AU - Dondero,Timothy J, AU - Pellett,Philip E, AU - Lackritz,Eve M, PY - 2006/9/29/pubmed PY - 2006/10/6/medline PY - 2006/9/29/entrez SP - 1331 EP - 8 JF - The New England journal of medicine JO - N Engl J Med VL - 355 IS - 13 N2 - BACKGROUND: Whether human herpesvirus 8 (HHV-8) is transmissible by blood transfusion remains undetermined. We evaluated the risk of HHV-8 transmission by blood transfusion in Uganda, where HHV-8 is endemic. METHODS: We enrolled patients in Kampala, Uganda, who had received blood transfusions between December 2000 and October 2001. Pretransfusion and multiple post-transfusion blood specimens from up to nine visits over a 6-month period were tested for HHV-8 antibody. We calculated the excess risk of seroconversion over time among recipients of HHV-8-seropositive blood as compared with recipients of seronegative blood. RESULTS: Of the 1811 transfusion recipients enrolled, 991 were HHV-8-seronegative before transfusion and completed the requisite follow-up, 43% of whom received HHV-8-seropositive blood and 57% of whom received seronegative blood. HHV-8 seroconversion occurred in 41 of the 991 recipients. The risk of seroconversion was significantly higher among recipients of HHV-8-seropositive blood than among recipients of seronegative blood (excess risk, 2.8%; P<0.05), and the increase in risk was seen mainly among patients in whom seroconversion occurred 3 to 10 weeks after transfusion (excess risk, 2.7%; P=0.005), a result consistent with the transmission of the virus by transfusion. Blood units stored for up to 4 days were more often associated with seroconversion than those stored for more than 4 days (excess risk, 4.2%; P<0.05). CONCLUSIONS: This study provides strong evidence that HHV-8 is transmitted by blood transfusion. The risk may be diminished as the period of blood storage increases. SN - 1533-4406 UR - https://www.unboundmedicine.com/medline/citation/17005950/Transmission_of_human_herpesvirus_8_by_blood_transfusion_ L2 - https://www.nejm.org/doi/10.1056/NEJMoa055009?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -