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A pilot study of chlorhexidine and benzydamine oral rinses for the prevention and treatment of irradiation mucositis in patients with head and neck cancer.
Cancer Nurs 2006 Sep-Oct; 29(5):423-30CN

Abstract

This pilot study was designed to compare the efficacy of 0.2% wt/vol chlorhexidine gluconate and 0.15% wt/vol benzydamine hydrochloride oral rinses in alleviating irradiation oropharyngeal mucositis for patients with head and neck cancer. This was a prospective, randomized, and double-blinded study. Fourteen subjects were stratified based on nasopharyngeal cancer and non-nasopharyngeal head and neck cancer, and were randomly assigned to receive oral care protocol either containing with chlorhexidine (n = 7) or benzydamine (n = 7) from the first day to 2 weeks after the completion of radiotherapy. Subjects were evaluated twice weekly through days 1 to 64 using the World Health Organization mucositis scale and the 10 cm visual analogue scale for mouth pain and dysphagia. In the chlorhexidine arm, 4 subjects (57%) had grade 2, and 3 subjects (43%) had grade 3 mucositis. In the benzydamine arm, 5 subjects (71%) had grade 2, and 2 subjects (29%) had grade 3 mucositis (P > .05). The mean area-under-the-curve values of mucositis were 26.5 +/- 13.6 (median 26) and 24.1 +/- 6.1 (median 22) in the chlorhexidine group and benzydamine group, respectively (P > .05). The mean area-under-the-curve values of pain and dysphagia were 70.8 +/- 33 (median 88.5) and 71.5 +/- 39 (median 101), and 62.1 +/- 17.2 (median 72) and 66 +/- 22.3 (median 57.5) in the chlorhexidine and benzydamine groups, respectively (P > .05). A trend has emerged of a lessening of severity of mucositis, pain, and dysphagia for patients with head and neck cancer receiving benzydamine oral rinse. The beneficial effects, however, need to be confirmed in a larger trial.

Authors+Show Affiliations

Faculty of Medicine, The Nethersole School of Nursing, Chung Chi College, The Chinese University of Hong Kong, Shatin, NT, Hong Kong. kariskwong@cuhk.edu.hkNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17006117

Citation

Kin-Fong Cheng, Karis, and Jacqueline Ka Tsui Yuen. "A Pilot Study of Chlorhexidine and Benzydamine Oral Rinses for the Prevention and Treatment of Irradiation Mucositis in Patients With Head and Neck Cancer." Cancer Nursing, vol. 29, no. 5, 2006, pp. 423-30.
Kin-Fong Cheng K, Ka Tsui Yuen J. A pilot study of chlorhexidine and benzydamine oral rinses for the prevention and treatment of irradiation mucositis in patients with head and neck cancer. Cancer Nurs. 2006;29(5):423-30.
Kin-Fong Cheng, K., & Ka Tsui Yuen, J. (2006). A pilot study of chlorhexidine and benzydamine oral rinses for the prevention and treatment of irradiation mucositis in patients with head and neck cancer. Cancer Nursing, 29(5), pp. 423-30.
Kin-Fong Cheng K, Ka Tsui Yuen J. A Pilot Study of Chlorhexidine and Benzydamine Oral Rinses for the Prevention and Treatment of Irradiation Mucositis in Patients With Head and Neck Cancer. Cancer Nurs. 2006;29(5):423-30. PubMed PMID: 17006117.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A pilot study of chlorhexidine and benzydamine oral rinses for the prevention and treatment of irradiation mucositis in patients with head and neck cancer. AU - Kin-Fong Cheng,Karis, AU - Ka Tsui Yuen,Jacqueline, PY - 2006/9/29/pubmed PY - 2006/11/11/medline PY - 2006/9/29/entrez SP - 423 EP - 30 JF - Cancer nursing JO - Cancer Nurs VL - 29 IS - 5 N2 - This pilot study was designed to compare the efficacy of 0.2% wt/vol chlorhexidine gluconate and 0.15% wt/vol benzydamine hydrochloride oral rinses in alleviating irradiation oropharyngeal mucositis for patients with head and neck cancer. This was a prospective, randomized, and double-blinded study. Fourteen subjects were stratified based on nasopharyngeal cancer and non-nasopharyngeal head and neck cancer, and were randomly assigned to receive oral care protocol either containing with chlorhexidine (n = 7) or benzydamine (n = 7) from the first day to 2 weeks after the completion of radiotherapy. Subjects were evaluated twice weekly through days 1 to 64 using the World Health Organization mucositis scale and the 10 cm visual analogue scale for mouth pain and dysphagia. In the chlorhexidine arm, 4 subjects (57%) had grade 2, and 3 subjects (43%) had grade 3 mucositis. In the benzydamine arm, 5 subjects (71%) had grade 2, and 2 subjects (29%) had grade 3 mucositis (P > .05). The mean area-under-the-curve values of mucositis were 26.5 +/- 13.6 (median 26) and 24.1 +/- 6.1 (median 22) in the chlorhexidine group and benzydamine group, respectively (P > .05). The mean area-under-the-curve values of pain and dysphagia were 70.8 +/- 33 (median 88.5) and 71.5 +/- 39 (median 101), and 62.1 +/- 17.2 (median 72) and 66 +/- 22.3 (median 57.5) in the chlorhexidine and benzydamine groups, respectively (P > .05). A trend has emerged of a lessening of severity of mucositis, pain, and dysphagia for patients with head and neck cancer receiving benzydamine oral rinse. The beneficial effects, however, need to be confirmed in a larger trial. SN - 1538-9804 UR - https://www.unboundmedicine.com/medline/citation/17006117/A_pilot_study_of_chlorhexidine_and_benzydamine_oral_rinses_for_the_prevention_and_treatment_of_irradiation_mucositis_in_patients_with_head_and_neck_cancer_ L2 - http://dx.doi.org/10.1097/00002820-200609000-00012 DB - PRIME DP - Unbound Medicine ER -