TY - JOUR T1 - Superior relative efficacy of live attenuated influenza vaccine compared with inactivated influenza vaccine in young children with recurrent respiratory tract infections. AU - Ashkenazi,Shai, AU - Vertruyen,Andre, AU - Arístegui,Javier, AU - Esposito,Susanna, AU - McKeith,David Douglas, AU - Klemola,Timo, AU - Biolek,Jiri, AU - Kühr,Joachim, AU - Bujnowski,Tadeusz, AU - Desgrandchamps,Daniel, AU - Cheng,Sheau-Mei, AU - Skinner,Jonathan, AU - Gruber,William C, AU - Forrest,Bruce D, AU - ,, PY - 2006/9/29/pubmed PY - 2006/12/21/medline PY - 2006/9/29/entrez SP - 870 EP - 9 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 25 IS - 10 N2 - BACKGROUND: Young children have a high incidence of influenza and influenza-related complications. This study compared the efficacy and safety of cold-adapted influenza vaccine, trivalent (CAIV-T) with trivalent inactivated influenza vaccine (TIV) in young children with a history of recurrent respiratory tract infections (RTIs). METHODS: Children 6 to 71 months of age were randomized to receive 2 doses of CAIV-T (n = 1101) or TIV (n = 1086), 35 +/- 7 days apart before the start of the 2002-2003 influenza season and were followed up for culture-confirmed influenza, effectiveness outcomes, reactogenicity, and adverse events. RESULTS: Overall, 52.7% (95% confidence interval [CI] = 21.6%-72.2%) fewer cases of influenza caused by virus strains antigenically similar to vaccine were observed in CAIV-T than in TIV recipients. Greater relative efficacy for CAIV-T was observed for the antigenically similar A/H1N1 (100.0%; 95% CI = 42.3%-100.0%) and B (68.0%; 95% CI = 37.3%-84.8%) strains but not for the antigenically similar A/H3N2 strains (-97.1%; 95% CI = -540.2% to 31.5%). Relative to TIV, CAIV-T reduced the number of RTI-related healthcare provider visits by 8.9% (90% CI = 1.5%-15.8%) and missed days of school, kindergarten, or day care by 16.2% (90% CI = 10.4%-21.6%). Rhinitis and rhinorrhea, otitis media, and decreased appetite were the only events that were reported more frequently in CAIV-T subjects. There was no difference between groups in the incidence of wheezing after vaccination. CONCLUSIONS: CAIV-T was well tolerated in these children with RTIs and demonstrated superior relative efficacy compared with TIV in preventing influenza illness. SN - 0891-3668 UR - https://www.unboundmedicine.com/medline/citation/17006279/Superior_relative_efficacy_of_live_attenuated_influenza_vaccine_compared_with_inactivated_influenza_vaccine_in_young_children_with_recurrent_respiratory_tract_infections_ L2 - https://doi.org/10.1097/01.inf.0000237829.66310.85 DB - PRIME DP - Unbound Medicine ER -