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Effect of soy isoflavone protein and soy lecithin on endothelial function in healthy postmenopausal women.
Menopause. 2007 Jan-Feb; 14(1):141-9.M

Abstract

OBJECTIVE

To assess the effects of soy isoflavone protein concentrate and soy lecithin on endothelial function, measured as flow-mediated dilation (FMD) of the brachial artery in healthy postmenopausal women.

DESIGN

This was a randomized, double-blind, placebo-controlled crossover trial with 25 participants (mean age, 61 years; body mass index, 25.46 kg/m2). The women underwent endothelial function testing at baseline and after 4 weeks of randomly assigned treatment with intervening 4-week washout periods. Treatment assignments included soy isoflavone protein (25 g/day) and soy lecithin (20 g/day), soy isoflavone protein (25 g/day) and placebo lecithin, placebo protein and soy lecithin (20 g/day), and double placebo. FMD and serum lipid levels were assessed at baseline and the end of each 4-week treatment phase.

RESULTS

Twenty-two women completed the trial. No statistically significant (P > 0.05) difference was seen in FMD between treatment groups. A trend was suggested with FMD highest after treatment with soy protein plus lecithin (7.50 +/- 9.85), followed by soy protein (5.51 +/- 10.11), soy lecithin (5.35 +/- 6.13), and lowest after placebo (4.53 +/- 7.84). Soy isoflavone protein and soy lecithin significantly increased the high-density lipoprotein/low-density lipoprotein ratio (soy isoflavone protein plus soy lecithin, 0.64 +/- 0.19, P < 0.0001; soy isoflavone protein plus placebo lecithin, 0.58 +/- 0.17, P = 0.0058; placebo protein plus soy lecithin, 0.65 +/- 0.18, P < 0.0001) relative to the baseline value (0.49 +/- 0.15).

CONCLUSIONS

In this sample of healthy postmenopausal women, soy isoflavone protein and soy lecithin significantly improved the lipid profile. A favorable influence on endothelial function could not be confirmed.

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Authors+Show Affiliations

Evans M
Yale Prevention Research Center, Derby, CT 06418, USA.
Njike VY
No affiliation info available
Hoxley M
No affiliation info available
Pearson M
No affiliation info available
Katz DL
No affiliation info available

MeSH

AgedBrachial ArteryCholineDouble-Blind MethodEndothelium, VascularFemaleHumansIsoflavonesLipoproteinsMiddle AgedPostmenopauseSoybean ProteinsVasodilation

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17006376

Citation

Evans, Marian, et al. "Effect of Soy Isoflavone Protein and Soy Lecithin On Endothelial Function in Healthy Postmenopausal Women." Menopause (New York, N.Y.), vol. 14, no. 1, 2007, pp. 141-9.
Evans M, Njike VY, Hoxley M, et al. Effect of soy isoflavone protein and soy lecithin on endothelial function in healthy postmenopausal women. Menopause. 2007;14(1):141-9.
Evans, M., Njike, V. Y., Hoxley, M., Pearson, M., & Katz, D. L. (2007). Effect of soy isoflavone protein and soy lecithin on endothelial function in healthy postmenopausal women. Menopause (New York, N.Y.), 14(1), 141-9.
Evans M, et al. Effect of Soy Isoflavone Protein and Soy Lecithin On Endothelial Function in Healthy Postmenopausal Women. Menopause. 2007 Jan-Feb;14(1):141-9. PubMed PMID: 17006376.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of soy isoflavone protein and soy lecithin on endothelial function in healthy postmenopausal women. AU - Evans,Marian, AU - Njike,Valentine Yanchou, AU - Hoxley,Martha, AU - Pearson,Meghan, AU - Katz,David L, PY - 2006/9/29/pubmed PY - 2007/4/27/medline PY - 2006/9/29/entrez SP - 141 EP - 9 JF - Menopause (New York, N.Y.) JO - Menopause VL - 14 IS - 1 N2 - OBJECTIVE: To assess the effects of soy isoflavone protein concentrate and soy lecithin on endothelial function, measured as flow-mediated dilation (FMD) of the brachial artery in healthy postmenopausal women. DESIGN: This was a randomized, double-blind, placebo-controlled crossover trial with 25 participants (mean age, 61 years; body mass index, 25.46 kg/m2). The women underwent endothelial function testing at baseline and after 4 weeks of randomly assigned treatment with intervening 4-week washout periods. Treatment assignments included soy isoflavone protein (25 g/day) and soy lecithin (20 g/day), soy isoflavone protein (25 g/day) and placebo lecithin, placebo protein and soy lecithin (20 g/day), and double placebo. FMD and serum lipid levels were assessed at baseline and the end of each 4-week treatment phase. RESULTS: Twenty-two women completed the trial. No statistically significant (P > 0.05) difference was seen in FMD between treatment groups. A trend was suggested with FMD highest after treatment with soy protein plus lecithin (7.50 +/- 9.85), followed by soy protein (5.51 +/- 10.11), soy lecithin (5.35 +/- 6.13), and lowest after placebo (4.53 +/- 7.84). Soy isoflavone protein and soy lecithin significantly increased the high-density lipoprotein/low-density lipoprotein ratio (soy isoflavone protein plus soy lecithin, 0.64 +/- 0.19, P < 0.0001; soy isoflavone protein plus placebo lecithin, 0.58 +/- 0.17, P = 0.0058; placebo protein plus soy lecithin, 0.65 +/- 0.18, P < 0.0001) relative to the baseline value (0.49 +/- 0.15). CONCLUSIONS: In this sample of healthy postmenopausal women, soy isoflavone protein and soy lecithin significantly improved the lipid profile. A favorable influence on endothelial function could not be confirmed. SN - 1072-3714 UR - https://www.unboundmedicine.com/medline/citation/17006376/Effect_of_soy_isoflavone_protein_and_soy_lecithin_on_endothelial_function_in_healthy_postmenopausal_women_ L2 - https://doi.org/10.1097/01.gme.0000227404.83686.1b DB - PRIME DP - Unbound Medicine ER -