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Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women.
Cancer Causes Control. 2006 Nov; 17(9):1209-13.CC

Abstract

OBJECTIVE

Adequate folate intake may be important for breast cancer prevention. Its protective effect may be influenced by factors associated with folate metabolism. We sought to evaluate folate intake in relation to breast cancer risk and examine whether the relation is affected by alcohol and intake of vitamin B(2) and B(12).

METHODS

A prospective cohort analysis of folate intake was conducted among 62,739 postmenopausal women in the French E3N cohort who had completed a validated food frequency questionnaire in 1993. During nine years' follow-up, 1,812 cases of pathology-confirmed breast cancer were documented through follow-up questionnaires. Nutrients were categorized in quintiles and energy-adjusted using the regression-residual method. Cox model-derived relative risks (RRs) were adjusted for known breast cancer determinants.

RESULTS

The multivariate RR for extreme quintiles of folate intake was 0.78 (95% CI: 0.67-0.90; p-trend = 0.001) [Median intake for Q(1) = 296 microg/day and Q(5) = 522 microg/day]. There was no evidence to support effect modification by alcohol or B(2) intake. The decreasing trend was most marked in women with higher folate and vitamin B(12)intake. However, test for interaction was not statistically significant (p = 0.29).

CONCLUSIONS

High folate intake was associated with decreased breast cancer risk. Vitamin B(12) intake may modify this association.

Authors+Show Affiliations

Inserm, (Institut National de la Santé et de la Recherche Médicale), ERI 20, Institut Gustave Roussy, 39 rue Camille Desmoulins, F-94805, Villejuif Cedex, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17006726

Citation

Lajous, Martin, et al. "Folate, Vitamin B12 and Postmenopausal Breast Cancer in a Prospective Study of French Women." Cancer Causes & Control : CCC, vol. 17, no. 9, 2006, pp. 1209-13.
Lajous M, Romieu I, Sabia S, et al. Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women. Cancer Causes Control. 2006;17(9):1209-13.
Lajous, M., Romieu, I., Sabia, S., Boutron-Ruault, M. C., & Clavel-Chapelon, F. (2006). Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women. Cancer Causes & Control : CCC, 17(9), 1209-13.
Lajous M, et al. Folate, Vitamin B12 and Postmenopausal Breast Cancer in a Prospective Study of French Women. Cancer Causes Control. 2006;17(9):1209-13. PubMed PMID: 17006726.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Folate, vitamin B12 and postmenopausal breast cancer in a prospective study of French women. AU - Lajous,Martin, AU - Romieu,Isabelle, AU - Sabia,Severine, AU - Boutron-Ruault,Marie-Christine, AU - Clavel-Chapelon,Françoise, PY - 2006/02/09/received PY - 2006/06/18/accepted PY - 2006/9/29/pubmed PY - 2007/2/3/medline PY - 2006/9/29/entrez SP - 1209 EP - 13 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 17 IS - 9 N2 - OBJECTIVE: Adequate folate intake may be important for breast cancer prevention. Its protective effect may be influenced by factors associated with folate metabolism. We sought to evaluate folate intake in relation to breast cancer risk and examine whether the relation is affected by alcohol and intake of vitamin B(2) and B(12). METHODS: A prospective cohort analysis of folate intake was conducted among 62,739 postmenopausal women in the French E3N cohort who had completed a validated food frequency questionnaire in 1993. During nine years' follow-up, 1,812 cases of pathology-confirmed breast cancer were documented through follow-up questionnaires. Nutrients were categorized in quintiles and energy-adjusted using the regression-residual method. Cox model-derived relative risks (RRs) were adjusted for known breast cancer determinants. RESULTS: The multivariate RR for extreme quintiles of folate intake was 0.78 (95% CI: 0.67-0.90; p-trend = 0.001) [Median intake for Q(1) = 296 microg/day and Q(5) = 522 microg/day]. There was no evidence to support effect modification by alcohol or B(2) intake. The decreasing trend was most marked in women with higher folate and vitamin B(12)intake. However, test for interaction was not statistically significant (p = 0.29). CONCLUSIONS: High folate intake was associated with decreased breast cancer risk. Vitamin B(12) intake may modify this association. SN - 0957-5243 UR - https://www.unboundmedicine.com/medline/citation/17006726/Folate_vitamin_B12_and_postmenopausal_breast_cancer_in_a_prospective_study_of_French_women_ L2 - https://doi.org/10.1007/s10552-006-0053-3 DB - PRIME DP - Unbound Medicine ER -