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Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish.
Dev Biol. 2006 Nov 15; 299(2):594-608.DB

Abstract

The functions of Myf5 and Myod are well known in trunk myogenesis. However, the roles that Myf5 and Myod play during craniofacial myogenesis are far from well known. We observed that zebrafish myf5 was detected in the primordia of the obliques, lateral rectus, sternohyoideus, and pharyngeal mesoderm cores. In contrast, myod transcripts were expressed in all head muscle precursors at later stages. Knockdown of myf5 revealed that Myf5 was required for the development of the obliques, lateral rectus, sternohyoideus, and all pharyngeal muscles, whereas knockdown of myod proved that Myod was required for the development of superior rectus, medial rectus, inferior rectus, lateral rectus, and the ventral pharyngeal muscles. myod mRNA did not rescue the loss of the cranial muscle caused by injecting myf5-morpholino, or vice versa, suggesting that the functions of Myf5 and Myod were not redundant in head paraxial mesoderm, a finding different from their functions in trunk myogenesis. Myf5, but not Myod, was required for the forward migration of myf5-positive oblique precursors. All evidences reveal that Myf5 and Myod function independently during cranial myogenesis. On the basis of the expression patterns of myf5 and myod, we propose a model to present how Myf5 and Myod are involved in head myogenesis of zebrafish.

Authors+Show Affiliations

Lin CY
Institute of Molecular and Cellular Biology, National Taiwan University, Room 307, Fisheries Science Building, No. 1, Section 4, Roosevelt Road, Taipei 106, Taiwan.
Yung RF
No affiliation info available
Lee HC
No affiliation info available
Chen WT
No affiliation info available
Chen YH
No affiliation info available
Tsai HJ
No affiliation info available

MeSH

AnimalsAnimals, Genetically ModifiedBranchial RegionCell MovementGene Expression Regulation, DevelopmentalHeadMesodermModels, BiologicalMuscle DevelopmentMuscle, SkeletalMyoD ProteinMyogenic Regulatory Factor 5ZebrafishZebrafish Proteins

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17007832

Citation

Lin, Cheng-Yung, et al. "Myogenic Regulatory Factors Myf5 and Myod Function Distinctly During Craniofacial Myogenesis of Zebrafish." Developmental Biology, vol. 299, no. 2, 2006, pp. 594-608.
Lin CY, Yung RF, Lee HC, et al. Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish. Dev Biol. 2006;299(2):594-608.
Lin, C. Y., Yung, R. F., Lee, H. C., Chen, W. T., Chen, Y. H., & Tsai, H. J. (2006). Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish. Developmental Biology, 299(2), 594-608.
Lin CY, et al. Myogenic Regulatory Factors Myf5 and Myod Function Distinctly During Craniofacial Myogenesis of Zebrafish. Dev Biol. 2006 Nov 15;299(2):594-608. PubMed PMID: 17007832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Myogenic regulatory factors Myf5 and Myod function distinctly during craniofacial myogenesis of zebrafish. AU - Lin,Cheng-Yung, AU - Yung,Rong-Feng, AU - Lee,Hung-Chieh, AU - Chen,Wei-Ta, AU - Chen,Yau-Hung, AU - Tsai,Huai-Jen, Y1 - 2006/08/24/ PY - 2006/01/30/received PY - 2006/07/21/revised PY - 2006/08/19/accepted PY - 2006/9/30/pubmed PY - 2007/1/17/medline PY - 2006/9/30/entrez SP - 594 EP - 608 JF - Developmental biology JO - Dev Biol VL - 299 IS - 2 N2 - The functions of Myf5 and Myod are well known in trunk myogenesis. However, the roles that Myf5 and Myod play during craniofacial myogenesis are far from well known. We observed that zebrafish myf5 was detected in the primordia of the obliques, lateral rectus, sternohyoideus, and pharyngeal mesoderm cores. In contrast, myod transcripts were expressed in all head muscle precursors at later stages. Knockdown of myf5 revealed that Myf5 was required for the development of the obliques, lateral rectus, sternohyoideus, and all pharyngeal muscles, whereas knockdown of myod proved that Myod was required for the development of superior rectus, medial rectus, inferior rectus, lateral rectus, and the ventral pharyngeal muscles. myod mRNA did not rescue the loss of the cranial muscle caused by injecting myf5-morpholino, or vice versa, suggesting that the functions of Myf5 and Myod were not redundant in head paraxial mesoderm, a finding different from their functions in trunk myogenesis. Myf5, but not Myod, was required for the forward migration of myf5-positive oblique precursors. All evidences reveal that Myf5 and Myod function independently during cranial myogenesis. On the basis of the expression patterns of myf5 and myod, we propose a model to present how Myf5 and Myod are involved in head myogenesis of zebrafish. SN - 0012-1606 UR - https://www.unboundmedicine.com/medline/citation/17007832/Myogenic_regulatory_factors_Myf5_and_Myod_function_distinctly_during_craniofacial_myogenesis_of_zebrafish_ DB - PRIME DP - Unbound Medicine ER -