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Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice.
Exp Neurol. 2007 Jan; 203(1):241-5.EN

Abstract

Consumption of caffeine, an adenosine receptor antagonist, was found to be inversely associated with the incidence of Alzheimer's disease. Moreover, caffeine protects cultured neurons against beta-amyloid-induced toxicity, an effect mimicked by adenosine A(2A) but not A(1) receptor antagonists. We now tested if caffeine administration would prevent beta-amyloid-induced cognitive impairment in mice and if this was mimicked by A(2A) receptor blockade. One week after icv administration of the 25-35 fragment of beta-amyloid (Abeta, 3 nmol), mice displayed impaired performance in both inhibitory avoidance and spontaneous alternation tests. Prolonged treatment with caffeine (1 mg/ml) had no effect alone but prevented the Abeta-induced cognitive impairment in both tasks when associated with acute caffeine (30 mg/kg) 30 min treatment before Abeta administration. The same protective effect was observed after subchronic (4 days) treatment with daily injections of either caffeine (30 mg/kg) or the selective adenosine A(2A) receptor antagonist SCH58261 (0.5 mg/kg). This provides the first direct in vivo evidence that caffeine and A(2A) receptor antagonists afford a protection against Abeta-induced amnesia, which prompts their interest for managing Alzheimer's disease.

Authors+Show Affiliations

Dall'Igna OP
Departamento de Bioquímica, ICBS, UFRGS, Porto Alegre, Brazil.
Fett P
No affiliation info available
Gomes MW
No affiliation info available
Souza DO
No affiliation info available
Cunha RA
No affiliation info available
Lara DR
No affiliation info available

MeSH

Adenosine A2 Receptor AntagonistsAlzheimer DiseaseAmnesiaAmyloid beta-PeptidesAnimalsAvoidance LearningBrainCaffeineCognition DisordersDisease Models, AnimalDrug SynergismMaleMaze LearningMiceNeuroprotective AgentsPeptide FragmentsPhosphodiesterase InhibitorsPyrimidinesReceptor, Adenosine A2ATreatment OutcomeTriazoles

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17007839

Citation

Dall'Igna, Oscar P., et al. "Caffeine and Adenosine A(2a) Receptor Antagonists Prevent Beta-amyloid (25-35)-induced Cognitive Deficits in Mice." Experimental Neurology, vol. 203, no. 1, 2007, pp. 241-5.
Dall'Igna OP, Fett P, Gomes MW, et al. Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice. Exp Neurol. 2007;203(1):241-5.
Dall'Igna, O. P., Fett, P., Gomes, M. W., Souza, D. O., Cunha, R. A., & Lara, D. R. (2007). Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice. Experimental Neurology, 203(1), 241-5.
Dall'Igna OP, et al. Caffeine and Adenosine A(2a) Receptor Antagonists Prevent Beta-amyloid (25-35)-induced Cognitive Deficits in Mice. Exp Neurol. 2007;203(1):241-5. PubMed PMID: 17007839.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice. AU - Dall'Igna,Oscar P, AU - Fett,Paulo, AU - Gomes,Marcio W, AU - Souza,Diogo O, AU - Cunha,Rodrigo A, AU - Lara,Diogo R, Y1 - 2006/09/27/ PY - 2006/05/05/received PY - 2006/07/27/revised PY - 2006/08/10/accepted PY - 2006/9/30/pubmed PY - 2007/2/24/medline PY - 2006/9/30/entrez SP - 241 EP - 5 JF - Experimental neurology JO - Exp Neurol VL - 203 IS - 1 N2 - Consumption of caffeine, an adenosine receptor antagonist, was found to be inversely associated with the incidence of Alzheimer's disease. Moreover, caffeine protects cultured neurons against beta-amyloid-induced toxicity, an effect mimicked by adenosine A(2A) but not A(1) receptor antagonists. We now tested if caffeine administration would prevent beta-amyloid-induced cognitive impairment in mice and if this was mimicked by A(2A) receptor blockade. One week after icv administration of the 25-35 fragment of beta-amyloid (Abeta, 3 nmol), mice displayed impaired performance in both inhibitory avoidance and spontaneous alternation tests. Prolonged treatment with caffeine (1 mg/ml) had no effect alone but prevented the Abeta-induced cognitive impairment in both tasks when associated with acute caffeine (30 mg/kg) 30 min treatment before Abeta administration. The same protective effect was observed after subchronic (4 days) treatment with daily injections of either caffeine (30 mg/kg) or the selective adenosine A(2A) receptor antagonist SCH58261 (0.5 mg/kg). This provides the first direct in vivo evidence that caffeine and A(2A) receptor antagonists afford a protection against Abeta-induced amnesia, which prompts their interest for managing Alzheimer's disease. SN - 0014-4886 UR - https://www.unboundmedicine.com/medline/citation/17007839/Caffeine_and_adenosine_A_2a__receptor_antagonists_prevent_beta_amyloid__25_35__induced_cognitive_deficits_in_mice_ DB - PRIME DP - Unbound Medicine ER -