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Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans.
Nutr Metab Cardiovasc Dis. 2007 Jul; 17(6):457-61.NM

Abstract

BACKGROUND AND AIMS

Ingestion of alpha linolenic acid (ALA), with the richest source among dry fruits such as walnuts, is associated with cardiovascular prevention. The aim of this study was to selectively evaluate the effects of moderate walnut consumption on the levels of ALA and its metabolic derivatives in human blood.

METHODS AND RESULTS

After a 2-week run-in period, 10 volunteers consumed 4 walnuts per day (in addition to their habitual diet) for 3 weeks. Fatty acid profiles, with special attention to levels of ALA and long chain polyunsaturated fatty acids (LC-PUFA), were assessed in blood drops collected from fingertips. The data indicate that the administration of a few walnuts a day for 3 weeks significantly increases blood levels, not only of ALA (from 0.23+/-0.07 SD to 0.47+/-0.13 SD), but also of its longer chain derivative eicosapentaenoic acids (EPA) (from 0.23+/-0.37 to 0.82+/-0.41) with levels remaining elevated over basal values after washout.

CONCLUSION

The findings of this pilot study indicate that plant ALA in appropriate food items favourably affects the n-3 LC-PUFA status.

Authors+Show Affiliations

Department of Pharmacological Sciences, University of Milan, Milan, Italy. franca.marangoni@unimi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17008073

Citation

Marangoni, Franca, et al. "Levels of the N-3 Fatty Acid Eicosapentaenoic Acid in Addition to Those of Alpha Linolenic Acid Are Significantly Raised in Blood Lipids By the Intake of Four Walnuts a Day in Humans." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 17, no. 6, 2007, pp. 457-61.
Marangoni F, Colombo C, Martiello A, et al. Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans. Nutr Metab Cardiovasc Dis. 2007;17(6):457-61.
Marangoni, F., Colombo, C., Martiello, A., Poli, A., Paoletti, R., & Galli, C. (2007). Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 17(6), 457-61.
Marangoni F, et al. Levels of the N-3 Fatty Acid Eicosapentaenoic Acid in Addition to Those of Alpha Linolenic Acid Are Significantly Raised in Blood Lipids By the Intake of Four Walnuts a Day in Humans. Nutr Metab Cardiovasc Dis. 2007;17(6):457-61. PubMed PMID: 17008073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Levels of the n-3 fatty acid eicosapentaenoic acid in addition to those of alpha linolenic acid are significantly raised in blood lipids by the intake of four walnuts a day in humans. AU - Marangoni,Franca, AU - Colombo,Claudio, AU - Martiello,Antonella, AU - Poli,Andrea, AU - Paoletti,Rodolfo, AU - Galli,Claudio, Y1 - 2006/09/26/ PY - 2005/06/17/received PY - 2005/12/06/revised PY - 2006/02/09/accepted PY - 2006/9/30/pubmed PY - 2007/8/19/medline PY - 2006/9/30/entrez SP - 457 EP - 61 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 17 IS - 6 N2 - BACKGROUND AND AIMS: Ingestion of alpha linolenic acid (ALA), with the richest source among dry fruits such as walnuts, is associated with cardiovascular prevention. The aim of this study was to selectively evaluate the effects of moderate walnut consumption on the levels of ALA and its metabolic derivatives in human blood. METHODS AND RESULTS: After a 2-week run-in period, 10 volunteers consumed 4 walnuts per day (in addition to their habitual diet) for 3 weeks. Fatty acid profiles, with special attention to levels of ALA and long chain polyunsaturated fatty acids (LC-PUFA), were assessed in blood drops collected from fingertips. The data indicate that the administration of a few walnuts a day for 3 weeks significantly increases blood levels, not only of ALA (from 0.23+/-0.07 SD to 0.47+/-0.13 SD), but also of its longer chain derivative eicosapentaenoic acids (EPA) (from 0.23+/-0.37 to 0.82+/-0.41) with levels remaining elevated over basal values after washout. CONCLUSION: The findings of this pilot study indicate that plant ALA in appropriate food items favourably affects the n-3 LC-PUFA status. SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/17008073/Levels_of_the_n_3_fatty_acid_eicosapentaenoic_acid_in_addition_to_those_of_alpha_linolenic_acid_are_significantly_raised_in_blood_lipids_by_the_intake_of_four_walnuts_a_day_in_humans_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(06)00067-6 DB - PRIME DP - Unbound Medicine ER -