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Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002.
Arterioscler Thromb Vasc Biol 2006; 26(12):2745-51AT

Abstract

OBJECTIVE

We performed a prospective case-cohort study in initially healthy, middle-aged men and women from the MONICA/KORA Augsburg studies conducted between 1984 and 2002 to assess the role of IL-18 in comparison with IL-6 and CRP in the prediction of incident coronary heart disease (CHD).

METHODS AND RESULTS

Concentrations of IL-18 were measured in 382 case subjects with incident CHD and 1980 noncases. Mean follow-up was 11 years. Baseline concentrations of IL-18 were slightly higher in cases than in noncases (172.4 [1.0] versus 161.3 [1.0] pg/mL, respectively; P=0.114), but were clearly elevated for C-reactive protein (CRP) and IL-6 in cases compared with noncases. In multivariable analyses, accounting for classical cardiovascular risk factors and inflammatory markers, no statistically significant association was seen between increased concentrations of IL-18 and incident CHD both in men (hazard ratio [HR] and 95% confidence intervals [CIs] comparing extreme tertiles, 1.20; 95% CI, 0.85 to 1.69), and in women (HR, 1.25; 95% CI, 0.67 to 2.34). However, in this population increased concentrations of CRP and IL-6 were found to be independent predictors of future CHD events, even after multivariable adjustment.

CONCLUSIONS

Elevated concentrations of CRP and IL-6, but not IL-18, were independently associated with risk of CHD in subjects from an area with moderate absolute risk.

Authors+Show Affiliations

Department of Internal Medicine II-Cardiology, University of Ulm Medical Center, Ulm, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17008587

Citation

Koenig, Wolfgang, et al. "Increased Concentrations of C-reactive Protein and IL-6 but Not IL-18 Are Independently Associated With Incident Coronary Events in Middle-aged Men and Women: Results From the MONICA/KORA Augsburg Case-cohort Study, 1984-2002." Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 26, no. 12, 2006, pp. 2745-51.
Koenig W, Khuseyinova N, Baumert J, et al. Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Arterioscler Thromb Vasc Biol. 2006;26(12):2745-51.
Koenig, W., Khuseyinova, N., Baumert, J., Thorand, B., Loewel, H., Chambless, L., ... Herder, C. (2006). Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(12), pp. 2745-51.
Koenig W, et al. Increased Concentrations of C-reactive Protein and IL-6 but Not IL-18 Are Independently Associated With Incident Coronary Events in Middle-aged Men and Women: Results From the MONICA/KORA Augsburg Case-cohort Study, 1984-2002. Arterioscler Thromb Vasc Biol. 2006;26(12):2745-51. PubMed PMID: 17008587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Increased concentrations of C-reactive protein and IL-6 but not IL-18 are independently associated with incident coronary events in middle-aged men and women: results from the MONICA/KORA Augsburg case-cohort study, 1984-2002. AU - Koenig,Wolfgang, AU - Khuseyinova,Natalie, AU - Baumert,Jens, AU - Thorand,Barbara, AU - Loewel,Hannelore, AU - Chambless,Lloyd, AU - Meisinger,Christa, AU - Schneider,Andrea, AU - Martin,Stephan, AU - Kolb,Hubert, AU - Herder,Christian, Y1 - 2006/09/28/ PY - 2006/9/30/pubmed PY - 2006/12/28/medline PY - 2006/9/30/entrez SP - 2745 EP - 51 JF - Arteriosclerosis, thrombosis, and vascular biology JO - Arterioscler. Thromb. Vasc. Biol. VL - 26 IS - 12 N2 - OBJECTIVE: We performed a prospective case-cohort study in initially healthy, middle-aged men and women from the MONICA/KORA Augsburg studies conducted between 1984 and 2002 to assess the role of IL-18 in comparison with IL-6 and CRP in the prediction of incident coronary heart disease (CHD). METHODS AND RESULTS: Concentrations of IL-18 were measured in 382 case subjects with incident CHD and 1980 noncases. Mean follow-up was 11 years. Baseline concentrations of IL-18 were slightly higher in cases than in noncases (172.4 [1.0] versus 161.3 [1.0] pg/mL, respectively; P=0.114), but were clearly elevated for C-reactive protein (CRP) and IL-6 in cases compared with noncases. In multivariable analyses, accounting for classical cardiovascular risk factors and inflammatory markers, no statistically significant association was seen between increased concentrations of IL-18 and incident CHD both in men (hazard ratio [HR] and 95% confidence intervals [CIs] comparing extreme tertiles, 1.20; 95% CI, 0.85 to 1.69), and in women (HR, 1.25; 95% CI, 0.67 to 2.34). However, in this population increased concentrations of CRP and IL-6 were found to be independent predictors of future CHD events, even after multivariable adjustment. CONCLUSIONS: Elevated concentrations of CRP and IL-6, but not IL-18, were independently associated with risk of CHD in subjects from an area with moderate absolute risk. SN - 1524-4636 UR - https://www.unboundmedicine.com/medline/citation/17008587/Increased_concentrations_of_C_reactive_protein_and_IL_6_but_not_IL_18_are_independently_associated_with_incident_coronary_events_in_middle_aged_men_and_women:_results_from_the_MONICA/KORA_Augsburg_case_cohort_study_1984_2002_ L2 - http://www.ahajournals.org/doi/full/10.1161/01.ATV.0000248096.62495.73?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -