Tags

Type your tag names separated by a space and hit enter

White matter changes in elderly people: MR-pathologic correlations.
Magn Reson Med Sci. 2006 Jul; 5(2):99-104.MR

Abstract

Magnetic resonance (MR) imaging features of white matter lesions, often seen in the elderly, are correlated with histologic findings. Dilatation of perivascular spaces is seen, especially in the frontal and/or parietal subcortical white matter; the spaces are less than 3 mm in diameter and have sharp margins with no perifocal abnormality. Old lacunar infarcts are larger than 3 mm in diameter and are irregularly shaped and accompanied by perifocal myelin pallor and gliosis. Periventricular hyperintensity, including cap and rim, histologically shows myelin pallor, dilatation of perivascular spaces, discontinuity of the ependymal lining, and subependymal gliosis. Deep and subcortical white matter hyperintensity reflects myelin pallor and dilatation of perivascular spaces. Diffuse white matter lesion, seen in Binswanger's disease, shows myelin pallor and tissue rarefaction associated with loss of myelin and axons. U-fibers are usually well preserved. Severe arteriosclerosis and arteriolosclerosis are usually seen in the white matter. Knowledge of the pathologic features of incidental changes in white matter helps in understanding MR imaging findings.

Authors+Show Affiliations

Division of Radiology, Department of Pathophysiological and Therapeutic Science, Tottori University, Japan. matsusue@grape.med.tottori-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

17008766

Citation

Matsusue, Eiji, et al. "White Matter Changes in Elderly People: MR-pathologic Correlations." Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine, vol. 5, no. 2, 2006, pp. 99-104.
Matsusue E, Sugihara S, Fujii S, et al. White matter changes in elderly people: MR-pathologic correlations. Magn Reson Med Sci. 2006;5(2):99-104.
Matsusue, E., Sugihara, S., Fujii, S., Ohama, E., Kinoshita, T., & Ogawa, T. (2006). White matter changes in elderly people: MR-pathologic correlations. Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine, 5(2), 99-104.
Matsusue E, et al. White Matter Changes in Elderly People: MR-pathologic Correlations. Magn Reson Med Sci. 2006;5(2):99-104. PubMed PMID: 17008766.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White matter changes in elderly people: MR-pathologic correlations. AU - Matsusue,Eiji, AU - Sugihara,Shuji, AU - Fujii,Shinya, AU - Ohama,Eisaku, AU - Kinoshita,Toshibumi, AU - Ogawa,Toshihide, PY - 2006/9/30/pubmed PY - 2007/4/28/medline PY - 2006/9/30/entrez SP - 99 EP - 104 JF - Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine JO - Magn Reson Med Sci VL - 5 IS - 2 N2 - Magnetic resonance (MR) imaging features of white matter lesions, often seen in the elderly, are correlated with histologic findings. Dilatation of perivascular spaces is seen, especially in the frontal and/or parietal subcortical white matter; the spaces are less than 3 mm in diameter and have sharp margins with no perifocal abnormality. Old lacunar infarcts are larger than 3 mm in diameter and are irregularly shaped and accompanied by perifocal myelin pallor and gliosis. Periventricular hyperintensity, including cap and rim, histologically shows myelin pallor, dilatation of perivascular spaces, discontinuity of the ependymal lining, and subependymal gliosis. Deep and subcortical white matter hyperintensity reflects myelin pallor and dilatation of perivascular spaces. Diffuse white matter lesion, seen in Binswanger's disease, shows myelin pallor and tissue rarefaction associated with loss of myelin and axons. U-fibers are usually well preserved. Severe arteriosclerosis and arteriolosclerosis are usually seen in the white matter. Knowledge of the pathologic features of incidental changes in white matter helps in understanding MR imaging findings. SN - 1347-3182 UR - https://www.unboundmedicine.com/medline/citation/17008766/White_matter_changes_in_elderly_people:_MR_pathologic_correlations_ L2 - http://japanlinkcenter.org/JST.JSTAGE/mrms/5.99?from=PubMed DB - PRIME DP - Unbound Medicine ER -