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Low-carbohydrate diet and oxidative stress in diabetic and nondiabetic rats.
J Biochem Mol Toxicol. 2006; 20(5):259-69.JB

Abstract

Hyperglycemia of diabetes has been implicated in increased tissue oxidative stress, with consequent development of secondary complications. Thus, stabilizing glucose levels near normal levels is of utmost importance. Because diet influences glycemic control, this study investigated whether a low-carbohydrate (5.5%) diet confers beneficial effects on the oxidative status of the heart, kidney, and liver in diabetes. Male and female normal and diabetic rats were fed standard chow (63% carbohydrates) or low-carbohydrate diet for 30 days. Elevated glucose, HbA(1c), and alanine and aspartate aminotransferases in diabetic animals were reduced or normalized by the low-carbohydrate diet. While diabetes increased cardiac activities of glutathione peroxidase and catalase, low-carbohydrate diet normalized cardiac glutathione peroxidase activity in diabetic animals, and reduced catalase activity in females. Diabetic rats fed low-carbohydrate diet had altered activities of renal glutathione reductase and superoxide dismutase, but increased renal glutathione peroxidase activity in diabetic animals was not corrected by the test diet. In the liver, diabetes was associated with a decrease in catalase activity and glutathione levels and an increase in glutathione peroxidase and gamma-glutamyltranspeptidase activities. Decreased hepatic glutathione peroxidase activity and lipid peroxidation were noted in diet-treated diabetic rats. Overall, the low-carbohydrate diet helped stabilize hyperglycemia and did not produce overtly negative effects in tissues of normal or diabetic rats.

Authors+Show Affiliations

Department of Medical Pharmacology, Faculty of Health Science, Moi University, Eldoret, Kenya.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17009256

Citation

Kamuren, Zipporah T., et al. "Low-carbohydrate Diet and Oxidative Stress in Diabetic and Nondiabetic Rats." Journal of Biochemical and Molecular Toxicology, vol. 20, no. 5, 2006, pp. 259-69.
Kamuren ZT, Sanders R, Watkins JB. Low-carbohydrate diet and oxidative stress in diabetic and nondiabetic rats. J Biochem Mol Toxicol. 2006;20(5):259-69.
Kamuren, Z. T., Sanders, R., & Watkins, J. B. (2006). Low-carbohydrate diet and oxidative stress in diabetic and nondiabetic rats. Journal of Biochemical and Molecular Toxicology, 20(5), 259-69.
Kamuren ZT, Sanders R, Watkins JB. Low-carbohydrate Diet and Oxidative Stress in Diabetic and Nondiabetic Rats. J Biochem Mol Toxicol. 2006;20(5):259-69. PubMed PMID: 17009256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Low-carbohydrate diet and oxidative stress in diabetic and nondiabetic rats. AU - Kamuren,Zipporah T, AU - Sanders,Ruth, AU - Watkins,John B,3rd PY - 2006/9/30/pubmed PY - 2006/11/14/medline PY - 2006/9/30/entrez SP - 259 EP - 69 JF - Journal of biochemical and molecular toxicology JO - J Biochem Mol Toxicol VL - 20 IS - 5 N2 - Hyperglycemia of diabetes has been implicated in increased tissue oxidative stress, with consequent development of secondary complications. Thus, stabilizing glucose levels near normal levels is of utmost importance. Because diet influences glycemic control, this study investigated whether a low-carbohydrate (5.5%) diet confers beneficial effects on the oxidative status of the heart, kidney, and liver in diabetes. Male and female normal and diabetic rats were fed standard chow (63% carbohydrates) or low-carbohydrate diet for 30 days. Elevated glucose, HbA(1c), and alanine and aspartate aminotransferases in diabetic animals were reduced or normalized by the low-carbohydrate diet. While diabetes increased cardiac activities of glutathione peroxidase and catalase, low-carbohydrate diet normalized cardiac glutathione peroxidase activity in diabetic animals, and reduced catalase activity in females. Diabetic rats fed low-carbohydrate diet had altered activities of renal glutathione reductase and superoxide dismutase, but increased renal glutathione peroxidase activity in diabetic animals was not corrected by the test diet. In the liver, diabetes was associated with a decrease in catalase activity and glutathione levels and an increase in glutathione peroxidase and gamma-glutamyltranspeptidase activities. Decreased hepatic glutathione peroxidase activity and lipid peroxidation were noted in diet-treated diabetic rats. Overall, the low-carbohydrate diet helped stabilize hyperglycemia and did not produce overtly negative effects in tissues of normal or diabetic rats. SN - 1095-6670 UR - https://www.unboundmedicine.com/medline/citation/17009256/Low_carbohydrate_diet_and_oxidative_stress_in_diabetic_and_nondiabetic_rats_ L2 - https://doi.org/10.1002/jbt.20142 DB - PRIME DP - Unbound Medicine ER -