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Alcohol and dietary fibre intakes affect circulating sex hormones among premenopausal women.

Abstract

BACKGROUND

The association of alcohol and fibre intake with breast cancer may be mediated by circulating sex hormone levels, which are predictors of breast cancer risk.

OBJECTIVE

To evaluate the relationship of alcohol and dietary fibre intake with circulating sex hormone levels among premenopausal women.

METHODS

A total of 205 premenopausal women completed a validated food-frequency questionnaire at baseline and after 2 years; blood samples taken at the same time were analysed for circulating sex hormone concentrations, including oestrone (E1), oestradiol (E2), free E2, progesterone, androstenedione and sex hormone-binding globulin, by radioimmunoassay. We used mixed models to estimate least-square means of sex hormone concentrations for alcohol intake categories and quartiles of dietary intake.

RESULTS

After adjustment for covariates, alcohol consumption was moderately associated with higher circulating oestrogen levels; those who consumed more than one drink per day had 20% higher E2 (Ptrend=0.07) levels than non-drinkers. In contrast, higher dietary fibre intake was associated with lower serum levels of androstenedione (-8% between the lowest and highest quartiles of intake, Ptrend=0.06), but not oestrogens. Similarly, consumption of fruits (-12%, Ptrend=0.03), vegetables (-9%, Ptrend=0.15) and whole grains (-7%, Ptrend=0.07) showed inverse associations with androstenedione levels.

CONCLUSIONS

The consistency of the observed differences in sex hormone levels associated with alcohol and fibre-rich foods indicates that these nutritional factors may affect sex hormone concentrations and play a role in breast cancer aetiology and prevention.

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  • Authors+Show Affiliations

    ,

    Cancer Research Center of Hawaii, 1236 Lauhala Street, Honolulu, HI 96813, USA. gertraud@crch.hawaii.edu

    , , ,

    Source

    Public health nutrition 9:7 2006 Oct pg 875-81

    MeSH

    Adolescent
    Adult
    Alcohol Drinking
    Androgens
    Androstenedione
    Breast Neoplasms
    Diet Surveys
    Dietary Fiber
    Edible Grain
    Estradiol
    Estrogens
    Female
    Fruit
    Gonadal Steroid Hormones
    Humans
    Premenopause
    Progesterone
    Risk Factors
    Sex Hormone-Binding Globulin
    Surveys and Questionnaires
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    17010253

    Citation

    Maskarinec, Gertraud, et al. "Alcohol and Dietary Fibre Intakes Affect Circulating Sex Hormones Among Premenopausal Women." Public Health Nutrition, vol. 9, no. 7, 2006, pp. 875-81.
    Maskarinec G, Morimoto Y, Takata Y, et al. Alcohol and dietary fibre intakes affect circulating sex hormones among premenopausal women. Public Health Nutr. 2006;9(7):875-81.
    Maskarinec, G., Morimoto, Y., Takata, Y., Murphy, S. P., & Stanczyk, F. Z. (2006). Alcohol and dietary fibre intakes affect circulating sex hormones among premenopausal women. Public Health Nutrition, 9(7), pp. 875-81.
    Maskarinec G, et al. Alcohol and Dietary Fibre Intakes Affect Circulating Sex Hormones Among Premenopausal Women. Public Health Nutr. 2006;9(7):875-81. PubMed PMID: 17010253.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Alcohol and dietary fibre intakes affect circulating sex hormones among premenopausal women. AU - Maskarinec,Gertraud, AU - Morimoto,Yukiko, AU - Takata,Yumie, AU - Murphy,Suzanne P, AU - Stanczyk,Frank Z, PY - 2006/10/3/pubmed PY - 2007/1/24/medline PY - 2006/10/3/entrez SP - 875 EP - 81 JF - Public health nutrition JO - Public Health Nutr VL - 9 IS - 7 N2 - BACKGROUND: The association of alcohol and fibre intake with breast cancer may be mediated by circulating sex hormone levels, which are predictors of breast cancer risk. OBJECTIVE: To evaluate the relationship of alcohol and dietary fibre intake with circulating sex hormone levels among premenopausal women. METHODS: A total of 205 premenopausal women completed a validated food-frequency questionnaire at baseline and after 2 years; blood samples taken at the same time were analysed for circulating sex hormone concentrations, including oestrone (E1), oestradiol (E2), free E2, progesterone, androstenedione and sex hormone-binding globulin, by radioimmunoassay. We used mixed models to estimate least-square means of sex hormone concentrations for alcohol intake categories and quartiles of dietary intake. RESULTS: After adjustment for covariates, alcohol consumption was moderately associated with higher circulating oestrogen levels; those who consumed more than one drink per day had 20% higher E2 (Ptrend=0.07) levels than non-drinkers. In contrast, higher dietary fibre intake was associated with lower serum levels of androstenedione (-8% between the lowest and highest quartiles of intake, Ptrend=0.06), but not oestrogens. Similarly, consumption of fruits (-12%, Ptrend=0.03), vegetables (-9%, Ptrend=0.15) and whole grains (-7%, Ptrend=0.07) showed inverse associations with androstenedione levels. CONCLUSIONS: The consistency of the observed differences in sex hormone levels associated with alcohol and fibre-rich foods indicates that these nutritional factors may affect sex hormone concentrations and play a role in breast cancer aetiology and prevention. SN - 1368-9800 UR - https://www.unboundmedicine.com/medline/citation/17010253/Alcohol_and_dietary_fibre_intakes_affect_circulating_sex_hormones_among_premenopausal_women_ L2 - https://www.cambridge.org/core/product/identifier/S1368980006001455/type/journal_article DB - PRIME DP - Unbound Medicine ER -