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Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance.
Diabetes Res Clin Pract 2007; 76(3):351-7DR

Abstract

AIM

To study fasting biologically active serum ghrelin (RIA) and resistin (ELISA) levels in different trimesters of pregnancy (HP, n=45, 15 in each) and in gestational diabetes mellitus (GDM, n=30) compared to non-pregnant healthy women (NP, n=40) in correlation with TNF-alpha, soluble (s)TNF-receptor (R)-1, -2, leptin (ELISA), C-peptide (Cp, RIA) and Cp/blood glucose ratio (bg).

STUDY DESIGN

Cross-sectional case control study.

RESULTS

Acylated ghrelin levels were significantly increased (p<0.0001) in the 2nd (377+/-38pg/ml, X+/-S.D.) and decreased in the 3rd trimester (252+/-36) and in GDM (226+/-21) compared to NP controls (309+/-20) and HP women in the 1st trimester (314+/-41). Serum resistin levels were higher in the 1st (8.5+/-2.6ng/ml), 2nd (10.2+/-2.1) and 3rd (13.1+/-3.6) trimesters of pregnancy and in GDM (15.7+/-3.5) than in NP controls (6.5+/-2.3). Significant (p<0.01) negative linear correlations were found among fasting serum ghrelin and body mass index (BMI), the fasting C-peptide (Cp) level, C-peptide/blood glucose (Cp/bg) ratio, TNF-alpha, soluble (s)TNFR-2, leptin and resistin concentrations in both, HP and GDM groups. Significant positive correlations were observed between serum acylated ghrelin and adiponectin, and between BMI and fasting Cp, Cp/bg, TNF-alpha, sTNFR-1, -2 and leptin levels in both pregnant groups.

CONCLUSION

Increased fasting serum acylated ghrelin concentrations in the 2nd trimester may associate with weight gain during pregnancy. Hyperresistinemia may also be associated with the pregnancy-induced insulin resistance. A negative regulatory feed-back mechanism between resistin, TNF-alpha and ghrelin may be hypothesized.

Authors+Show Affiliations

3rd Department of Medicine, Semmelweis University, H-1125 Kútvölgyi u 4, Budapest, Hungary. palikeva@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17010469

Citation

Palik, Eva, et al. "Elevated Serum Acylated (biologically Active) Ghrelin and Resistin Levels Associate With Pregnancy-induced Weight Gain and Insulin Resistance." Diabetes Research and Clinical Practice, vol. 76, no. 3, 2007, pp. 351-7.
Palik E, Baranyi E, Melczer Z, et al. Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance. Diabetes Res Clin Pract. 2007;76(3):351-7.
Palik, E., Baranyi, E., Melczer, Z., Audikovszky, M., Szöcs, A., Winkler, G., & Cseh, K. (2007). Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance. Diabetes Research and Clinical Practice, 76(3), pp. 351-7.
Palik E, et al. Elevated Serum Acylated (biologically Active) Ghrelin and Resistin Levels Associate With Pregnancy-induced Weight Gain and Insulin Resistance. Diabetes Res Clin Pract. 2007;76(3):351-7. PubMed PMID: 17010469.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance. AU - Palik,Eva, AU - Baranyi,Eva, AU - Melczer,Zsolt, AU - Audikovszky,Maria, AU - Szöcs,Albert, AU - Winkler,Gábor, AU - Cseh,Károly, Y1 - 2006/09/28/ PY - 2006/01/04/received PY - 2006/09/04/accepted PY - 2006/10/3/pubmed PY - 2007/7/17/medline PY - 2006/10/3/entrez SP - 351 EP - 7 JF - Diabetes research and clinical practice JO - Diabetes Res. Clin. Pract. VL - 76 IS - 3 N2 - AIM: To study fasting biologically active serum ghrelin (RIA) and resistin (ELISA) levels in different trimesters of pregnancy (HP, n=45, 15 in each) and in gestational diabetes mellitus (GDM, n=30) compared to non-pregnant healthy women (NP, n=40) in correlation with TNF-alpha, soluble (s)TNF-receptor (R)-1, -2, leptin (ELISA), C-peptide (Cp, RIA) and Cp/blood glucose ratio (bg). STUDY DESIGN: Cross-sectional case control study. RESULTS: Acylated ghrelin levels were significantly increased (p<0.0001) in the 2nd (377+/-38pg/ml, X+/-S.D.) and decreased in the 3rd trimester (252+/-36) and in GDM (226+/-21) compared to NP controls (309+/-20) and HP women in the 1st trimester (314+/-41). Serum resistin levels were higher in the 1st (8.5+/-2.6ng/ml), 2nd (10.2+/-2.1) and 3rd (13.1+/-3.6) trimesters of pregnancy and in GDM (15.7+/-3.5) than in NP controls (6.5+/-2.3). Significant (p<0.01) negative linear correlations were found among fasting serum ghrelin and body mass index (BMI), the fasting C-peptide (Cp) level, C-peptide/blood glucose (Cp/bg) ratio, TNF-alpha, soluble (s)TNFR-2, leptin and resistin concentrations in both, HP and GDM groups. Significant positive correlations were observed between serum acylated ghrelin and adiponectin, and between BMI and fasting Cp, Cp/bg, TNF-alpha, sTNFR-1, -2 and leptin levels in both pregnant groups. CONCLUSION: Increased fasting serum acylated ghrelin concentrations in the 2nd trimester may associate with weight gain during pregnancy. Hyperresistinemia may also be associated with the pregnancy-induced insulin resistance. A negative regulatory feed-back mechanism between resistin, TNF-alpha and ghrelin may be hypothesized. SN - 0168-8227 UR - https://www.unboundmedicine.com/medline/citation/17010469/Elevated_serum_acylated__biologically_active__ghrelin_and_resistin_levels_associate_with_pregnancy_induced_weight_gain_and_insulin_resistance_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0168-8227(06)00388-3 DB - PRIME DP - Unbound Medicine ER -