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Strategies for developing vaccines against H5N1 influenza A viruses.
Trends Mol Med. 2006 Nov; 12(11):506-14.TM

Abstract

Recent outbreaks of highly pathogenic avian influenza A virus (H5N1 subtype) infections in poultry and humans (through direct contact with infected birds) have raised concerns that a new influenza pandemic might occur in the near future. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse-genetics-based inactivated vaccines have been prepared according to World Health Organization (WHO) recommendations and are now undergoing clinical evaluation in several countries. Here, we review the current strategies for the development of H5N1 influenza vaccines, and future directions for vaccine development.

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Authors+Show Affiliations

Horimoto T
Division of Virology, Department of Microbiology and Immunology, International Research Center for Infectious Diseases, Institute of Medical Science, University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Kawaoka Y
No affiliation info available

MeSH

AnimalsChemistry, PharmaceuticalChickensChlorocebus aethiopsDisease OutbreaksHumansInfluenza A Virus, H5N1 SubtypeInfluenza VaccinesInfluenza in BirdsInfluenza, HumanModels, GeneticModels, ImmunologicalOrthomyxoviridae InfectionsVero CellsVirulence FactorsVirus Replication

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17011235

Citation

Horimoto, Taisuke, and Yoshihiro Kawaoka. "Strategies for Developing Vaccines Against H5N1 Influenza a Viruses." Trends in Molecular Medicine, vol. 12, no. 11, 2006, pp. 506-14.
Horimoto T, Kawaoka Y. Strategies for developing vaccines against H5N1 influenza A viruses. Trends Mol Med. 2006;12(11):506-14.
Horimoto, T., & Kawaoka, Y. (2006). Strategies for developing vaccines against H5N1 influenza A viruses. Trends in Molecular Medicine, 12(11), 506-14.
Horimoto T, Kawaoka Y. Strategies for Developing Vaccines Against H5N1 Influenza a Viruses. Trends Mol Med. 2006;12(11):506-14. PubMed PMID: 17011235.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Strategies for developing vaccines against H5N1 influenza A viruses. AU - Horimoto,Taisuke, AU - Kawaoka,Yoshihiro, Y1 - 2006/09/29/ PY - 2006/05/12/received PY - 2006/08/16/revised PY - 2006/09/15/accepted PY - 2006/10/3/pubmed PY - 2007/2/13/medline PY - 2006/10/3/entrez SP - 506 EP - 14 JF - Trends in molecular medicine JO - Trends Mol Med VL - 12 IS - 11 N2 - Recent outbreaks of highly pathogenic avian influenza A virus (H5N1 subtype) infections in poultry and humans (through direct contact with infected birds) have raised concerns that a new influenza pandemic might occur in the near future. Effective vaccines against H5N1 virus are, therefore, urgently needed. Reverse-genetics-based inactivated vaccines have been prepared according to World Health Organization (WHO) recommendations and are now undergoing clinical evaluation in several countries. Here, we review the current strategies for the development of H5N1 influenza vaccines, and future directions for vaccine development. SN - 1471-4914 UR - https://www.unboundmedicine.com/medline/citation/17011235/Strategies_for_developing_vaccines_against_H5N1_influenza_A_viruses_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1471-4914(06)00199-7 DB - PRIME DP - Unbound Medicine ER -